TMBIM4 (transmembrane BAX inhibitor motif containing 4) - Rat Genome Database

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Gene: TMBIM4 (transmembrane BAX inhibitor motif containing 4) Canis lupus familiaris
Analyze
Symbol: TMBIM4
Name: transmembrane BAX inhibitor motif containing 4
RGD ID: 12200083
Description: INVOLVED IN locomotory behavior (inferred); negative regulation of apoptotic process (inferred); negative regulation of neuron apoptotic process (inferred); ASSOCIATED WITH genetic disease (ortholog); ovarian cyst (ortholog); FOUND IN Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane BAX inhibitor motif-containing protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,643,982 - 8,670,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,575,311 - 8,602,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0108,756,350 - 8,783,338 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,753,197 - 8,783,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,632,641 - 8,659,591 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,878,118 - 8,905,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,999,868 - 9,026,838 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TMBIM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,643,982 - 8,670,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,575,311 - 8,602,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0108,756,350 - 8,783,338 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,753,197 - 8,783,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,632,641 - 8,659,591 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,878,118 - 8,905,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,999,868 - 9,026,838 (-)NCBIUU_Cfam_GSD_1.0
TMBIM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381266,135,846 - 66,169,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1266,135,846 - 66,170,027 (-)EnsemblGRCh38hg38GRCh38
GRCh371266,529,626 - 66,563,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,816,984 - 64,850,074 (-)NCBINCBI36Build 36hg18NCBI36
Celera1266,194,786 - 66,228,037 (-)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,581,354 - 63,614,468 (-)NCBIHuRef
CHM1_11266,497,573 - 66,530,663 (-)NCBICHM1_1
T2T-CHM13v2.01266,115,352 - 66,149,503 (-)NCBIT2T-CHM13v2.0
Tmbim4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,044,731 - 120,060,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,037,495 - 120,060,822 (+)EnsemblGRCm39 Ensembl
GRCm3810120,208,826 - 120,224,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,201,590 - 120,224,917 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710119,645,882 - 119,661,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610119,611,886 - 119,627,957 (+)NCBIMGSCv36mm8
Celera10122,570,626 - 122,587,068 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Tmbim4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,604,275 - 57,618,861 (+)NCBIGRCr8
mRatBN7.2755,718,690 - 55,733,277 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,718,699 - 55,742,773 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,625,111 - 57,639,700 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,828,292 - 59,842,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,605,633 - 59,620,225 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0764,987,859 - 65,002,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,987,859 - 65,002,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,206,720 - 65,221,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,473,341 - 59,487,931 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,494,073 - 59,508,661 (+)NCBI
Celera752,474,084 - 52,488,667 (+)NCBICelera
Cytogenetic Map7q22NCBI
Tmbim4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545812,795,445 - 12,818,277 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545812,795,484 - 12,818,277 (-)NCBIChiLan1.0ChiLan1.0
TMBIM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,185,329 - 28,218,615 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,182,105 - 28,215,384 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,739,658 - 22,773,228 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11223,246,329 - 23,279,160 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1223,246,329 - 23,279,160 (+)Ensemblpanpan1.1panPan2
Tmbim4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494549,885,050 - 49,902,779 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365454,207,342 - 4,225,158 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365454,207,344 - 4,225,071 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMBIM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,488,328 - 30,511,533 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,488,319 - 30,511,558 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,729,166 - 33,785,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMBIM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,817,688 - 61,850,747 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1161,815,738 - 61,850,716 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037183,873,879 - 183,906,897 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmbim4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,137,612 - 2,173,854 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248022,137,580 - 2,172,402 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMBIM4
347 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845022380   ⟹   ENSCAFP00845017586
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl108,753,197 - 8,783,353 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845022419   ⟹   ENSCAFP00845017613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl108,756,601 - 8,783,353 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845022445   ⟹   ENSCAFP00845017631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl108,763,244 - 8,783,353 (-)Ensembl
RefSeq Acc Id: XM_038488037   ⟹   XP_038343965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1108,632,641 - 8,659,591 (-)NCBI
RefSeq Acc Id: XM_038549931   ⟹   XP_038405859
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0108,999,868 - 9,026,838 (-)NCBI
RefSeq Acc Id: XM_038613907   ⟹   XP_038469835
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0108,878,118 - 8,905,130 (-)NCBI
RefSeq Acc Id: XM_038679261   ⟹   XP_038535189
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0108,756,350 - 8,783,338 (-)NCBI
RefSeq Acc Id: XM_531662   ⟹   XP_531662
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1108,643,982 - 8,670,948 (-)NCBI
Dog10K_Boxer_Tasha108,575,311 - 8,602,280 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_531662   ⟸   XM_531662
- UniProtKB: A0A8C0L1I7 (UniProtKB/TrEMBL),   A0A8C0N2Z2 (UniProtKB/TrEMBL),   A0A8I3RZH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038343965   ⟸   XM_038488037
RefSeq Acc Id: XP_038469835   ⟸   XM_038613907
RefSeq Acc Id: XP_038535189   ⟸   XM_038679261
- UniProtKB: A0A8C0L1I7 (UniProtKB/TrEMBL),   A0A8C0N2Z2 (UniProtKB/TrEMBL),   A0A8I3RZH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405859   ⟸   XM_038549931
- UniProtKB: A0A8C0L1I7 (UniProtKB/TrEMBL),   A0A8C0N2Z2 (UniProtKB/TrEMBL),   A0A8I3RZH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017586   ⟸   ENSCAFT00845022380
RefSeq Acc Id: ENSCAFP00845017613   ⟸   ENSCAFT00845022419
RefSeq Acc Id: ENSCAFP00845017631   ⟸   ENSCAFT00845022445


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000370 UniProtKB/TrEMBL
  ENSCAFG00030011396 UniProtKB/TrEMBL
  ENSCAFG00040021982 UniProtKB/TrEMBL
  ENSCAFG00845012562 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000579.5 UniProtKB/TrEMBL
  ENSCAFT00000091577.2 UniProtKB/TrEMBL
  ENSCAFT00000092354.2 UniProtKB/TrEMBL
  ENSCAFT00030021153.1 UniProtKB/TrEMBL
  ENSCAFT00030021256.1 UniProtKB/TrEMBL
  ENSCAFT00030021292.1 UniProtKB/TrEMBL
  ENSCAFT00040040803.1 UniProtKB/TrEMBL
  ENSCAFT00040040846.1 UniProtKB/TrEMBL
  ENSCAFT00040040871.1 UniProtKB/TrEMBL
  ENSCAFT00845022380 ENTREZGENE
  ENSCAFT00845022380.1 UniProtKB/TrEMBL
  ENSCAFT00845022419.1 UniProtKB/TrEMBL
  ENSCAFT00845022445.1 UniProtKB/TrEMBL
InterPro Bax_inhibitor_1-related UniProtKB/TrEMBL
NCBI Gene TMBIM4 ENTREZGENE
PANTHER GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR23291 UniProtKB/TrEMBL
Pfam Bax1-I UniProtKB/TrEMBL
UniProt A0A8C0L1I7 ENTREZGENE
  A0A8C0MXW3_CANLF UniProtKB/TrEMBL
  A0A8C0N2Z2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TJL0_CANLF UniProtKB/TrEMBL
  A0A8I3NBZ2_CANLF UniProtKB/TrEMBL
  A0A8I3NPZ2_CANLF UniProtKB/TrEMBL
  A0A8I3RZH8 ENTREZGENE, UniProtKB/TrEMBL