SRD5A1 (steroid 5 alpha-reductase 1) - Rat Genome Database

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Gene: SRD5A1 (steroid 5 alpha-reductase 1) Canis lupus familiaris
Analyze
Symbol: SRD5A1
Name: steroid 5 alpha-reductase 1
RGD ID: 12199061
Description: ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); NADPH binding (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen catabolic process (ortholog); androgen metabolic process (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATED WITH breast carcinoma (ortholog); Cardiomegaly (ortholog); COVID-19 (ortholog); FOUND IN cell body fiber (ortholog); neuronal cell body (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; prostatic steroid 5-alpha-reductase type I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,118,814 - 7,144,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10906740   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SRD5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,118,814 - 7,144,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBIUU_Cfam_GSD_1.0
SRD5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,633,440 - 6,674,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl56,633,290 - 6,676,539 (+)EnsemblGRCh38hg38GRCh38
GRCh3756,633,553 - 6,674,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,686,500 - 6,722,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3456,686,562 - 6,722,673NCBI
Celera56,660,560 - 6,696,748 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,608,126 - 6,644,172 (+)NCBIHuRef
CHM1_156,633,460 - 6,669,635 (+)NCBICHM1_1
T2T-CHM13v2.056,564,115 - 6,605,062 (+)NCBIT2T-CHM13v2.0
Srd5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,721,568 - 69,759,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,721,568 - 69,759,561 (-)EnsemblGRCm39 Ensembl
GRCm381369,573,449 - 69,611,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,573,449 - 69,611,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,712,327 - 69,750,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361370,040,821 - 70,078,835 (-)NCBIMGSCv36mm8
Celera1371,919,533 - 71,956,201 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Srd5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,514,914 - 35,548,898 (+)NCBIGRCr8
mRatBN7.2133,686,069 - 33,720,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,686,391 - 33,720,461 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,515,801 - 33,550,297 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,514,407 - 39,548,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,714,648 - 33,748,614 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
Srd5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,360,453 - 4,391,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,360,909 - 4,388,964 (+)NCBIChiLan1.0ChiLan1.0
SRD5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v246,880,973 - 6,916,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,034,510 - 5,069,665 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v056,953,795 - 6,996,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.156,629,093 - 6,664,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,629,093 - 6,664,264 (+)Ensemblpanpan1.1panPan2
Srd5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,167,012 - 240,207,515 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936634758,231 - 798,809 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,310,211 - 75,335,391 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,309,830 - 75,335,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,671,335 - 81,695,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,312,770 - 6,348,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,312,757 - 6,350,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606422,370,694 - 22,406,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,309,447 - 4,336,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247514,309,518 - 4,335,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SRD5A1
332 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 3 9 3 3 6 7 1 10 6
Low 4 2 13 3 6 3 6 5 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000037777   ⟹   ENSCAFP00000033377
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl347,126,237 - 7,144,828 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071905   ⟹   ENSCAFP00000051308
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl347,118,814 - 7,144,828 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042054   ⟹   ENSCAFP00845032983
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl347,026,936 - 7,052,848 (-)Ensembl
RefSeq Acc Id: NM_001287100   ⟹   NP_001274029
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1347,118,814 - 7,144,828 (-)NCBI
Dog10K_Boxer_Tasha3411,627,110 - 11,653,073 (-)NCBI
ROS_Cfam_1.0347,026,936 - 7,052,848 (-)NCBI
UMICH_Zoey_3.1347,074,036 - 7,099,998 (-)NCBI
UNSW_CanFamBas_1.0347,054,526 - 7,080,522 (-)NCBI
UU_Cfam_GSD_1.0347,269,539 - 7,295,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445382   ⟹   XP_038301310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0347,026,936 - 7,052,677 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001274029 (Get FASTA)   NCBI Sequence Viewer  
  XP_038301310 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF91079 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000051308.2
  ENSCAFP00030017477.1
  ENSCAFP00030017543.1
  ENSCAFP00040038990.1
  ENSCAFP00845032983
  ENSCAFP00845032983.1
Reference Protein Sequences
RefSeq Acc Id: NP_001274029   ⟸   NM_001287100
- UniProtKB: A0A8P0P128 (UniProtKB/TrEMBL),   A0A8C0N0Y7 (UniProtKB/TrEMBL),   A0A8I3PTX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000033377   ⟸   ENSCAFT00000037777
RefSeq Acc Id: ENSCAFP00000051308   ⟸   ENSCAFT00000071905
RefSeq Acc Id: XP_038301310   ⟸   XM_038445382
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N0Y7 (UniProtKB/TrEMBL),   A0A8I3PTX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032983   ⟸   ENSCAFT00845042054
Protein Domains
Steroid 5-alpha reductase C-terminal

Promoters
RGD ID:13688861
Promoter ID:EPDNEW_C6929
Type:multiple initiation site
Name:SRD5A1_1
Description:steroid 5 alpha-reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C6930  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1347,144,674 - 7,144,734EPDNEW
RGD ID:13688864
Promoter ID:EPDNEW_C6930
Type:multiple initiation site
Name:SRD5A1_2
Description:steroid 5 alpha-reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C6929  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1347,144,788 - 7,144,848EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010323 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010842 UniProtKB/TrEMBL
  ENSCAFG00040023955 UniProtKB/TrEMBL
  ENSCAFG00845023819 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000071905.2 UniProtKB/TrEMBL
  ENSCAFT00030020050.1 UniProtKB/TrEMBL
  ENSCAFT00030020117.1 UniProtKB/TrEMBL
  ENSCAFT00040044638.1 UniProtKB/TrEMBL
  ENSCAFT00845042054 ENTREZGENE
  ENSCAFT00845042054.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1630 UniProtKB/TrEMBL
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/TrEMBL
  3-oxo-5_a-steroid_4-DH_C UniProtKB/TrEMBL
  SRD5A/TECR UniProtKB/TrEMBL
KEGG Report cfa:403716 UniProtKB/TrEMBL
NCBI Gene SRD5A1 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 UniProtKB/TrEMBL
  PTHR10556 UniProtKB/TrEMBL
Pfam Steroid_dh UniProtKB/TrEMBL
PIRSF 5_alpha-SR2 UniProtKB/TrEMBL
PROSITE S5A_REDUCTASE UniProtKB/TrEMBL
UniProt A0A8C0N077_CANLF UniProtKB/TrEMBL
  A0A8C0N0Y7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PTX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P128 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46793 ENTREZGENE