CFAP58 (cilia and flagella associated protein 58) - Rat Genome Database

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Gene: CFAP58 (cilia and flagella associated protein 58) Canis lupus familiaris
Analyze
Symbol: CFAP58
Name: cilia and flagella associated protein 58
RGD ID: 12197665
Description: INVOLVED IN cilium assembly (ortholog); flagellated sperm motility (ortholog); Notch signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog); oligoasthenoteratozoospermia (ortholog); spermatogenic failure 49 (ortholog); FOUND IN centrosome (ortholog); sperm flagellum (ortholog); sperm midpiece (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CCDC147; cilia- and flagella-associated protein 58; coiled-coil domain containing 147
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,653,212 - 16,752,229 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,653,208 - 16,751,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2816,825,614 - 16,924,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02817,131,371 - 17,228,860 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12816,678,840 - 16,777,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02816,707,588 - 16,812,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02816,846,275 - 16,945,449 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CFAP58
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,653,212 - 16,752,229 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,653,208 - 16,751,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2816,825,614 - 16,924,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02817,131,371 - 17,228,860 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12816,678,840 - 16,777,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02816,707,588 - 16,812,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02816,846,275 - 16,945,449 (+)NCBIUU_Cfam_GSD_1.0
CFAP58
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810104,338,520 - 104,455,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10104,353,833 - 104,455,102 (+)EnsemblGRCh38hg38GRCh38
GRCh3710106,098,278 - 106,214,860 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,103,512 - 106,204,838 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410106,103,511 - 106,204,838NCBI
Celera1099,854,331 - 99,955,667 (+)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef1099,745,240 - 99,846,554 (+)NCBIHuRef
CHM1_110106,397,331 - 106,498,658 (+)NCBICHM1_1
T2T-CHM13v2.010105,226,654 - 105,343,247 (+)NCBIT2T-CHM13v2.0
Cfap58
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391947,926,151 - 48,023,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1947,926,114 - 48,023,826 (+)EnsemblGRCm39 Ensembl
GRCm381947,937,712 - 48,035,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1947,937,675 - 48,035,387 (+)EnsemblGRCm38mm10GRCm38
MGSCv371948,012,202 - 48,109,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361947,991,023 - 48,088,690 (+)NCBIMGSCv36mm8
Celera1948,698,683 - 48,796,374 (+)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1940.6NCBI
Cfap58
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,743,971 - 256,852,633 (+)NCBIGRCr8
mRatBN7.21246,802,691 - 246,911,363 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,802,665 - 246,911,374 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01267,689,258 - 267,798,291 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1271,292,390 - 271,400,597 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,689,328 - 267,798,059 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,121,111 - 275,228,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1242,566,673 - 242,673,552 (+)NCBICelera
Cytogenetic Map1q54-q55NCBI
Cfap58
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554856,213,542 - 6,319,376 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554856,208,412 - 6,319,367 (-)NCBIChiLan1.0ChiLan1.0
CFAP58
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28116,192,127 - 116,343,369 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110116,197,456 - 116,348,641 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010100,905,434 - 101,056,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110104,403,971 - 104,514,920 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10104,412,171 - 104,514,920 (+)Ensemblpanpan1.1panPan2
Cfap58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721330,166,018 - 30,259,707 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366001,769,851 - 1,862,876 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366001,769,243 - 1,861,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP58
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14115,285,979 - 115,410,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114115,292,386 - 115,410,852 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214125,263,625 - 125,381,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP58
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1997,400,284 - 97,510,489 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl997,409,380 - 97,510,661 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604858,507,377 - 58,634,452 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap58
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248313,418,036 - 3,508,971 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248313,418,104 - 3,509,769 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CFAP58
1216 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 1 4 8 4
Below cutoff 5 5 18 6 6 6 5 6 8 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016870   ⟹   ENSCAFP00000015612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2816,653,208 - 16,751,838 (+)Ensembl
RefSeq Acc Id: XM_003639998   ⟹   XP_003640046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12816,653,212 - 16,752,229 (+)NCBI
Dog10K_Boxer_Tasha2816,825,614 - 16,924,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038440508   ⟹   XP_038296436
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02817,131,371 - 17,228,860 (+)NCBI
RefSeq Acc Id: XM_038515131   ⟹   XP_038371059
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12816,678,840 - 16,777,928 (+)NCBI
RefSeq Acc Id: XM_038578739   ⟹   XP_038434667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02816,846,275 - 16,945,449 (+)NCBI
RefSeq Acc Id: XM_038642921   ⟹   XP_038498849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02816,707,588 - 16,812,819 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003640046   ⟸   XM_003639998
- Peptide Label: isoform X5
- UniProtKB: A0A8C0TS74 (UniProtKB/TrEMBL),   A0A8P0NCL9 (UniProtKB/TrEMBL),   A0A8C0KEA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000015612   ⟸   ENSCAFT00000016870
RefSeq Acc Id: XP_038371059   ⟸   XM_038515131
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038498849   ⟸   XM_038642921
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038296436   ⟸   XM_038440508
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038434667   ⟸   XM_038578739
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KEA7 (UniProtKB/TrEMBL),   A0A8C0TS74 (UniProtKB/TrEMBL),   A0A8P0NCL9 (UniProtKB/TrEMBL)
Protein Domains
Cilia- and flagella-associated protein 58 central


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010608 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022023 UniProtKB/TrEMBL
  ENSCAFG00040025086 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016870.5 UniProtKB/TrEMBL
  ENSCAFT00030040424.1 UniProtKB/TrEMBL
  ENSCAFT00040046785.1 UniProtKB/TrEMBL
InterPro CFAP58_CC UniProtKB/TrEMBL
KEGG Report cfa:477815 UniProtKB/TrEMBL
NCBI Gene CFAP58 ENTREZGENE
PANTHER CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED UniProtKB/TrEMBL
  CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 58 UniProtKB/TrEMBL
Pfam DUF6871 UniProtKB/TrEMBL
UniProt A0A8C0KEA7 ENTREZGENE
  A0A8C0TS74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NCL9 ENTREZGENE
UniProt Secondary A0A8P0NCL9 UniProtKB/TrEMBL
VGNC ID VGNC:39167 ENTREZGENE