CA1 (carbonic anhydrase 1) - Rat Genome Database

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Gene: CA1 (carbonic anhydrase 1) Canis lupus familiaris
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Symbol: CA1
Name: carbonic anhydrase 1
RGD ID: 12197233
Description: ENCODES a protein that exhibits arylesterase activity (inferred); carbonate dehydratase activity (inferred); zinc ion binding (inferred); INVOLVED IN one-carbon metabolic process (inferred); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH adenocarcinoma (ortholog); esophagus squamous cell carcinoma (ortholog); inherited metabolic disorder (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: INFERRED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,858,644 - 31,868,135 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,858,636 - 31,868,158 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,144,441 - 32,154,240 (-)NCBI
ROS_Cfam_1.02932,007,771 - 32,017,260 (-)NCBI
UMICH_Zoey_3.12932,058,957 - 32,068,728 (-)NCBI
UNSW_CanFamBas_1.02932,080,387 - 32,089,882 (-)NCBI
UU_Cfam_GSD_1.02932,466,958 - 32,476,446 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

Genomics

Comparative Map Data
CA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,858,644 - 31,868,135 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,858,636 - 31,868,158 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,144,441 - 32,154,240 (-)NCBI
ROS_Cfam_1.02932,007,771 - 32,017,260 (-)NCBI
UMICH_Zoey_3.12932,058,957 - 32,068,728 (-)NCBI
UNSW_CanFamBas_1.02932,080,387 - 32,089,882 (-)NCBI
UU_Cfam_GSD_1.02932,466,958 - 32,476,446 (-)NCBI
CA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl885,327,608 - 85,379,014 (-)EnsemblGRCh38hg38GRCh38
GRCh38885,327,608 - 85,378,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37886,239,837 - 86,290,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,427,709 - 86,477,594 (-)NCBINCBI36hg18NCBI36
Build 34886,427,708 - 86,477,594NCBI
Celera882,245,509 - 82,295,378 (-)NCBI
Cytogenetic Map8q21.2NCBI
HuRef881,734,656 - 81,784,498 (-)NCBIHuRef
CHM1_1886,292,190 - 86,342,064 (-)NCBICHM1_1
Car1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,831,274 - 14,873,425 (-)NCBIGRCm39mm39
GRCm39 Ensembl314,831,276 - 14,873,428 (-)Ensembl
GRCm38314,766,214 - 14,808,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,766,216 - 14,808,368 (-)EnsemblGRCm38mm10GRCm38
MGSCv37314,766,214 - 14,808,365 (-)NCBIGRCm37mm9NCBIm37
MGSCv36314,742,975 - 14,767,557 (-)NCBImm8
Celera314,771,712 - 14,813,913 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.18NCBI
Car1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,829,436 - 86,872,209 (+)NCBI
Rnor_6.0 Ensembl288,217,188 - 88,227,479 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0288,185,204 - 88,227,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02107,958,483 - 108,000,765 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,166,412 - 88,210,693 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1288,143,727 - 88,155,654 (+)NCBI
Celera282,427,032 - 82,469,698 (+)NCBICelera
Cytogenetic Map2q23NCBI
Ca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,270,619 - 3,305,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554173,270,619 - 3,313,261 (-)NCBIChiLan1.0ChiLan1.0
CA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1883,464,680 - 83,515,359 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl883,463,434 - 83,526,899 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0881,854,390 - 81,905,728 (-)NCBIMhudiblu_PPA_v0panPan3
Ca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,504,905 - 47,545,941 (+)NCBI
SpeTri2.0NW_004936544246,797 - 257,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,302,406 - 51,353,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,343,548 - 51,353,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,358,354 - 56,367,895 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,699,114 - 80,729,932 (-)NCBI
ChlSab1.1 Ensembl880,699,651 - 80,712,858 (-)Ensembl
Ca1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247446,244,872 - 6,324,722 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 4
Medium 1 1 1
Low 4 1 8 1
Below cutoff 5 20 6 1 6 4 2 12 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000013843   ⟹   ENSCAFP00000012806
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2931,858,644 - 31,868,158 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069255   ⟹   ENSCAFP00000048755
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2931,858,636 - 31,868,113 (-)Ensembl
RefSeq Acc Id: NM_001145171   ⟹   NP_001138643
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12931,858,644 - 31,868,135 (-)NCBI
Dog10K_Boxer_Tasha2932,144,441 - 32,154,240 (-)NCBI
ROS_Cfam_1.02932,007,771 - 32,017,260 (-)NCBI
UMICH_Zoey_3.12932,058,957 - 32,068,728 (-)NCBI
UNSW_CanFamBas_1.02932,080,387 - 32,089,882 (-)NCBI
UU_Cfam_GSD_1.02932,466,958 - 32,476,446 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001138643 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001138643   ⟸   NM_001145171
- UniProtKB: F1PBK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000048755   ⟸   ENSCAFT00000069255
RefSeq Acc Id: ENSCAFP00000012806   ⟸   ENSCAFT00000013843
Protein Domains
Alpha-carbonic anhydrase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000012806 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000048755 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013843 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000069255 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro Carbonic_anhydrase_a UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_a_sf UniProtKB/TrEMBL
  Carbonic_anhydrase_CA1 UniProtKB/TrEMBL
KEGG Report cfa:487031 UniProtKB/TrEMBL
NCBI Gene CA1 ENTREZGENE
PANTHER PTHR18952 UniProtKB/TrEMBL
  PTHR18952:SF82 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/TrEMBL
UniProt A0A5F4C3F2_CANLF UniProtKB/TrEMBL
  F1PBK6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38604 ENTREZGENE