MINDY4B (MINDY family member 4B) - Rat Genome Database

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Gene: MINDY4B (MINDY family member 4B) Canis lupus familiaris
Analyze
Symbol: MINDY4B
Name: MINDY family member 4B
RGD ID: 12195206
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH glycogen storage disease XV (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B; LOC102155588; uncharacterized LOC102155588
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,455,973 - 45,481,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,456,036 - 45,491,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,322,828 - 45,357,592 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02346,084,496 - 46,119,465 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2346,084,514 - 46,119,471 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12345,673,747 - 45,708,821 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02345,726,308 - 45,761,390 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02346,002,728 - 46,037,458 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MINDY4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,455,973 - 45,481,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,456,036 - 45,491,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,322,828 - 45,357,592 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02346,084,496 - 46,119,465 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2346,084,514 - 46,119,471 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12345,673,747 - 45,708,821 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02345,726,308 - 45,761,390 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02346,002,728 - 46,037,458 (-)NCBIUU_Cfam_GSD_1.0
MINDY4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383150,870,376 - 150,905,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3150,870,376 - 150,905,439 (-)EnsemblGRCh38hg38GRCh38
GRCh373150,588,163 - 150,623,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363152,071,522 - 152,105,916 (-)NCBINCBI36Build 36hg18NCBI36
Celera3149,001,782 - 149,033,992 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3147,962,147 - 147,994,318 (-)NCBIHuRef
CHM1_13150,552,171 - 150,572,669 (-)NCBICHM1_1
T2T-CHM13v2.03153,621,470 - 153,656,526 (-)NCBIT2T-CHM13v2.0
Mindy4b-ps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39358,697,538 - 58,727,655 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl358,695,828 - 58,729,732 (-)EnsemblGRCm39 Ensembl
GRCm38358,790,117 - 58,822,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl358,788,407 - 58,822,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37358,592,325 - 58,595,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36358,594,042 - 58,624,137 (-)NCBIMGSCv36mm8
Celera358,482,342 - 58,485,961 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map328.75NCBI
Mindy4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,175,510 - 145,208,165 (-)NCBIGRCr8
mRatBN7.22143,026,685 - 143,061,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2143,027,285 - 143,058,144 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02149,004,738 - 149,025,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2148,993,072 - 149,014,838 (-)NCBIRnor6.0rn6Rnor6.0
Celera2137,467,657 - 137,488,014 (-)NCBICelera
Cytogenetic Map2q26NCBI
MINDY4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22148,769,814 - 148,804,200 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13148,774,544 - 148,808,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03147,898,609 - 147,945,757 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,471,591 - 155,491,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3155,471,591 - 155,505,966 (-)Ensemblpanpan1.1panPan2
Mindy4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,535,159 - 90,564,704 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367581,203,803 - 1,224,340 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MINDY4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,786,459 - 39,825,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604112,607,527 - 12,644,022 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mindy4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473028,311,989 - 28,328,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MINDY4B
412 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 5 1
Below cutoff 4 3 20 5 5 5 1 10 8 9 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000045048   ⟹   ENSCAFP00000042563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2345,456,036 - 45,491,057 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045202   ⟹   ENSCAFP00845035442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2346,084,514 - 46,119,471 (-)Ensembl
RefSeq Acc Id: XM_038431617   ⟹   XP_038287545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02346,084,496 - 46,119,465 (-)NCBI
RefSeq Acc Id: XM_038457038   ⟹   XP_038312966
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2345,322,828 - 45,357,592 (-)NCBI
RefSeq Acc Id: XM_038506987   ⟹   XP_038362915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12345,673,747 - 45,708,821 (-)NCBI
RefSeq Acc Id: XM_038570204   ⟹   XP_038426132
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02346,002,728 - 46,037,458 (-)NCBI
RefSeq Acc Id: XM_038634359   ⟹   XP_038490287
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02345,726,308 - 45,761,390 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000042563   ⟸   ENSCAFT00000045048
RefSeq Acc Id: XP_038362915   ⟸   XM_038506987
RefSeq Acc Id: XP_038490287   ⟸   XM_038634359
RefSeq Acc Id: XP_038287545   ⟸   XM_038431617
- UniProtKB: A0A8I3PY78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038312966   ⟸   XM_038457038
- UniProtKB: A0A8C0N1N7 (UniProtKB/TrEMBL),   A0A8P0NT58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038426132   ⟸   XM_038570204
- UniProtKB: A0A8C0N1N7 (UniProtKB/TrEMBL),   A0A8P0NT58 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845035442   ⟸   ENSCAFT00845045202
Protein Domains
Deubiquitinating enzyme MINDY-3/4 conserved


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029264 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010955 UniProtKB/TrEMBL
  ENSCAFG00040012519 UniProtKB/TrEMBL
  ENSCAFG00845025559 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045048.3 UniProtKB/TrEMBL
  ENSCAFT00030020380.1 UniProtKB/TrEMBL
  ENSCAFT00040023160.1 UniProtKB/TrEMBL
  ENSCAFT00845045202 ENTREZGENE
  ENSCAFT00845045202.1 UniProtKB/TrEMBL
InterPro MINDY-3/4_CD UniProtKB/TrEMBL
  MINY3/4 UniProtKB/TrEMBL
NCBI Gene LOC102155588 ENTREZGENE
PANTHER INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4B UniProtKB/TrEMBL
  PTHR12473 UniProtKB/TrEMBL
Pfam DUF4205 UniProtKB/TrEMBL
SMART DUF4205 UniProtKB/TrEMBL
UniProt A0A8C0N1N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SFP2_CANLF UniProtKB/TrEMBL
  A0A8I3PY78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NT58 ENTREZGENE
UniProt Secondary A0A8P0NT58 UniProtKB/TrEMBL
VGNC ID VGNC:59056 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 MINDY4B  MINDY family member 4B  LOC102155588  uncharacterized LOC102155588  Symbol and/or name change 5135510 APPROVED