PMEL (premelanosome protein) - Rat Genome Database

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Gene: PMEL (premelanosome protein) Canis lupus familiaris
Analyze
Symbol: PMEL
Name: premelanosome protein
RGD ID: 12194613
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN melanin biosynthetic process (ortholog); melanosome organization (ortholog); positive regulation of melanin biosynthetic process (ortholog); ASSOCIATED WITH coat/hair pigmentation trait; melanoma (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: melanocyte protein PMEL; Pmel17; pre-melanosomal protein 17; SILV
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110292,595 - 327,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10292,597 - 300,098 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10354,530 - 362,031 (-)NCBI
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
UMICH_Zoey_3.110277,211 - 284,717 (-)NCBI
UNSW_CanFamBas_1.010519,995 - 527,495 (-)NCBI
UU_Cfam_GSD_1.010644,259 - 651,766 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
melanoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Experimental Data Annotations     Click to see Annotation Detail View

Vertebrate Trait

References
Additional References at PubMed
PMID:16407134   PMID:17931401   PMID:18052939   PMID:31238727   PMID:32560567  


Genomics

Comparative Map Data
PMEL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110292,595 - 327,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10292,597 - 300,098 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10354,530 - 362,031 (-)NCBI
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
UMICH_Zoey_3.110277,211 - 284,717 (-)NCBI
UNSW_CanFamBas_1.010519,995 - 527,495 (-)NCBI
UU_Cfam_GSD_1.010644,259 - 651,766 (-)NCBI
PMEL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,954,105 - 55,973,317 (-)EnsemblGRCh38hg38GRCh38
GRCh381255,954,105 - 55,966,709 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,347,889 - 56,360,493 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,634,156 - 54,646,093 (-)NCBINCBI36hg18NCBI36
Build 341254,634,156 - 54,646,093NCBI
Celera1256,000,543 - 56,012,534 (-)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,386,917 - 53,399,406 (-)NCBIHuRef
CHM1_11256,315,023 - 56,327,629 (-)NCBICHM1_1
Pmel
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,531,757 - 128,556,107 (+)NCBIGRCm39mm39
GRCm39 Ensembl10128,540,064 - 128,556,107 (+)Ensembl
GRCm3810128,695,888 - 128,720,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,704,195 - 128,720,238 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710128,143,314 - 128,157,294 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610128,109,207 - 128,123,073 (+)NCBImm8
Celera10131,098,390 - 131,112,396 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.13NCBI
Pmel
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,138,202 - 1,148,735 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl71,138,586 - 1,148,746 (+)Ensembl
Rnor_6.073,133,347 - 3,143,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,133,506 - 3,143,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,105,316 - 3,116,614 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,007,882 - 2,018,998 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.172,008,881 - 2,018,859 (+)NCBI
Celera71,008,541 - 1,019,007 (+)NCBICelera
Cytogenetic Map7q11NCBI
Pmel
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,544,961 - 3,554,619 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,544,855 - 3,555,453 (-)NCBIChiLan1.0ChiLan1.0
PMEL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,196,656 - 33,207,610 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,196,040 - 33,207,610 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,946,951 - 32,958,205 (+)NCBIMhudiblu_PPA_v0panPan3
Pmel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,491,116 - 58,502,171 (+)NCBI
SpeTri2.0NW_004936646368,064 - 379,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMEL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,355,619 - 21,365,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,355,611 - 21,365,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PMEL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,892,131 - 51,905,073 (-)NCBI
ChlSab1.1 Ensembl1151,887,730 - 51,904,324 (-)Ensembl
Vero_WHO_p1.0NW_023666037194,082,197 - 194,095,017 (+)NCBI
Pmel
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,073,932 - 12,092,885 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 15 1 2 1 5 11 6 6
Below cutoff 5 5 7 5 4 5 1 5 1 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001103216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022423998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022423999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ306880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF090519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF601583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG733981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG739568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000132   ⟹   ENSCAFP00000000115
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10292,597 - 300,098 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060394   ⟹   ENSCAFP00000050108
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10292,597 - 300,093 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000064306   ⟹   ENSCAFP00000045181
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10292,597 - 298,088 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084493   ⟹   ENSCAFP00000046863
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10292,597 - 300,093 (-)Ensembl
RefSeq Acc Id: NM_001103216   ⟹   NP_001096686
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,597 - 300,098 (-)NCBI
Dog10K_Boxer_Tasha10354,530 - 362,031 (-)NCBI
ROS_Cfam_1.010299,405 - 306,909 (-)NCBI
UMICH_Zoey_3.110277,211 - 284,717 (-)NCBI
UNSW_CanFamBas_1.010519,995 - 527,495 (-)NCBI
UU_Cfam_GSD_1.010644,259 - 651,766 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022423998   ⟹   XP_022279706
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 327,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022423999   ⟹   XP_022279707
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 327,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424000   ⟹   XP_022279708
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 327,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424001   ⟹   XP_022279709
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 307,646 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424002   ⟹   XP_022279710
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 327,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424003   ⟹   XP_022279711
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 327,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424004   ⟹   XP_022279712
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 327,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424005   ⟹   XP_022279713
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110292,595 - 301,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038678780   ⟹   XP_038534708
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
RefSeq Acc Id: XM_038678781   ⟹   XP_038534709
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 314,654 (-)NCBI
RefSeq Acc Id: XM_038678782   ⟹   XP_038534710
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
RefSeq Acc Id: XM_038678783   ⟹   XP_038534711
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
RefSeq Acc Id: XM_038678784   ⟹   XP_038534712
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 315,549 (-)NCBI
RefSeq Acc Id: XM_038678785   ⟹   XP_038534713
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 310,410 (-)NCBI
RefSeq Acc Id: XM_038678787   ⟹   XP_038534715
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
RefSeq Acc Id: XM_038678788   ⟹   XP_038534716
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010299,404 - 334,246 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001096686   ⟸   NM_001103216
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_022279712   ⟸   XM_022424004
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022279707   ⟸   XM_022423999
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022279711   ⟸   XM_022424003
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022279708   ⟸   XM_022424000
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022279710   ⟸   XM_022424002
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022279706   ⟸   XM_022423998
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022279709   ⟸   XM_022424001
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022279713   ⟸   XM_022424005
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSCAFP00000045181   ⟸   ENSCAFT00000064306
RefSeq Acc Id: ENSCAFP00000050108   ⟸   ENSCAFT00000060394
RefSeq Acc Id: ENSCAFP00000046863   ⟸   ENSCAFT00000084493
RefSeq Acc Id: ENSCAFP00000000115   ⟸   ENSCAFT00000000132
RefSeq Acc Id: XP_038534711   ⟸   XM_038678783
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038534708   ⟸   XM_038678780
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038534716   ⟸   XM_038678788
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038534710   ⟸   XM_038678782
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038534715   ⟸   XM_038678787
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038534712   ⟸   XM_038678784
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038534709   ⟸   XM_038678781
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038534713   ⟸   XM_038678785
- Peptide Label: isoform X4

Promoters
RGD ID:13684862
Promoter ID:EPDNEW_C2930
Type:single initiation site
Name:PMEL_1
Description:premelanosome protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110308,106 - 308,166EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000080 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000000115 ENTREZGENE
Ensembl Transcript ENSCAFT00000000132 ENTREZGENE
NCBI Gene PMEL ENTREZGENE
VGNC ID VGNC:44730 ENTREZGENE