KNL1 (kinetochore scaffold 1) - Rat Genome Database

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Gene: KNL1 (kinetochore scaffold 1) Canis lupus familiaris
Analyze
Symbol: KNL1
Name: kinetochore scaffold 1
RGD ID: 12194379
Description: INVOLVED IN homologous chromosome orientation in meiotic metaphase I (ortholog); positive regulation of meiosis I spindle assembly checkpoint (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein CASC5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,753,515 - 7,825,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,753,432 - 7,821,588 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,807,365 - 7,878,953 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,879,642 - 7,951,470 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,879,704 - 7,947,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,803,766 - 7,875,282 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,910,285 - 7,981,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,039,288 - 8,110,906 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KNL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,753,515 - 7,825,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,753,432 - 7,821,588 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,807,365 - 7,878,953 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,879,642 - 7,951,470 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,879,704 - 7,947,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,803,766 - 7,875,282 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,910,285 - 7,981,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,039,288 - 8,110,906 (+)NCBIUU_Cfam_GSD_1.0
KNL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,594,249 - 40,664,342 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,594,020 - 40,664,342 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,886,447 - 40,956,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,673,739 - 38,742,173 (+)NCBINCBI36Build 36hg18NCBI36
Celera1517,654,336 - 17,722,770 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,733,703 - 17,802,065 (+)NCBIHuRef
CHM1_11541,006,562 - 41,074,962 (+)NCBICHM1_1
T2T-CHM13v2.01538,399,974 - 38,470,044 (+)NCBIT2T-CHM13v2.0
Knl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,877,600 - 118,940,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,877,600 - 118,935,982 (+)EnsemblGRCm39 Ensembl
GRCm382119,047,119 - 119,110,497 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,047,119 - 119,105,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,872,855 - 118,929,857 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,738,474 - 118,795,562 (+)NCBIMGSCv36mm8
MGSCv362119,993,968 - 120,051,070 (+)NCBIMGSCv36mm8
Celera2120,199,115 - 120,256,832 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.85NCBI
Knl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,483,498 - 126,545,774 (+)NCBIGRCr8
mRatBN7.23106,029,627 - 106,091,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,029,661 - 106,091,915 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,710,464 - 109,764,974 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,306,007 - 118,360,519 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,966,384 - 116,020,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,847,304 - 110,909,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,855,000 - 110,909,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,385,194 - 117,453,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,561,365 - 105,615,047NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3104,950,722 - 105,005,517 (+)NCBICelera
Cytogenetic Map3q35NCBI
Knl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,500,415 - 7,562,273 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,498,983 - 7,561,620 (+)NCBIChiLan1.0ChiLan1.0
KNL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,839,231 - 29,909,645 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,990,711 - 34,061,124 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,539,264 - 19,609,593 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,792,411 - 37,856,095 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,801,705 - 37,860,858 (+)Ensemblpanpan1.1panPan2
Knl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,231,814 - 86,262,142 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,059,995 - 4,109,413 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,079,877 - 4,110,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KNL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11130,652,493 - 130,728,989 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KNL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,342,741 - 42,409,466 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604898,564,109 - 98,634,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Knl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,889,689 - 7,952,384 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,884,580 - 7,952,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KNL1
841 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 4 6 6 3
Below cutoff 1 5 22 6 6 6 12 7 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005638255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005638256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014109668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038461420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038516485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038516486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038580075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038580076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038644355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038644356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000014647   ⟹   ENSCAFP00000013547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl307,753,432 - 7,821,588 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845050661   ⟹   ENSCAFP00845039715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl307,879,704 - 7,947,949 (+)Ensembl
RefSeq Acc Id: XM_005638256   ⟹   XP_005638313
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1307,753,516 - 7,825,019 (+)NCBI
Dog10K_Boxer_Tasha307,807,365 - 7,878,953 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038441994   ⟹   XP_038297922
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0307,879,642 - 7,951,470 (+)NCBI
RefSeq Acc Id: XM_038441995   ⟹   XP_038297923
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0307,879,666 - 7,951,470 (+)NCBI
RefSeq Acc Id: XM_038461420   ⟹   XP_038317348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha307,807,389 - 7,878,953 (+)NCBI
RefSeq Acc Id: XM_038516485   ⟹   XP_038372413
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1307,803,766 - 7,875,282 (+)NCBI
RefSeq Acc Id: XM_038516486   ⟹   XP_038372414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1307,803,791 - 7,875,282 (+)NCBI
RefSeq Acc Id: XM_038580075   ⟹   XP_038436003
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0308,039,288 - 8,110,906 (+)NCBI
RefSeq Acc Id: XM_038580076   ⟹   XP_038436004
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0308,039,312 - 8,110,906 (+)NCBI
RefSeq Acc Id: XM_038644355   ⟹   XP_038500283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0307,910,285 - 7,981,708 (+)NCBI
RefSeq Acc Id: XM_038644356   ⟹   XP_038500284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0307,910,309 - 7,981,708 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005638313   ⟸   XM_005638256
- UniProtKB: A0A8C0JYD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000013547   ⟸   ENSCAFT00000014647
RefSeq Acc Id: XP_038372413   ⟸   XM_038516485
RefSeq Acc Id: XP_038372414   ⟸   XM_038516486
RefSeq Acc Id: XP_038500283   ⟸   XM_038644355
RefSeq Acc Id: XP_038500284   ⟸   XM_038644356
RefSeq Acc Id: XP_038297922   ⟸   XM_038441994
- UniProtKB: A0A8I3Q1C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038297923   ⟸   XM_038441995
- UniProtKB: A0A8I3Q1C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317348   ⟸   XM_038461420
- UniProtKB: A0A8C0JYD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436003   ⟸   XM_038580075
- UniProtKB: A0A8C0JYD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436004   ⟸   XM_038580076
- UniProtKB: A0A8C0JYD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845039715   ⟸   ENSCAFT00845050661
Protein Domains
Knl1 C-terminal RWD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009202 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845028680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014647.5 UniProtKB/TrEMBL
  ENSCAFT00845050661 ENTREZGENE
  ENSCAFT00845050661.1 UniProtKB/TrEMBL
InterPro Blinkin UniProtKB/TrEMBL
  KNL1_MELT_rep UniProtKB/TrEMBL
  Knl1_RWD_C UniProtKB/TrEMBL
NCBI Gene KNL1 ENTREZGENE
PANTHER KINETOCHORE SCAFFOLD 1 UniProtKB/TrEMBL
  PTHR16520 UniProtKB/TrEMBL
Pfam Knl1_RWD_C UniProtKB/TrEMBL
  MELT UniProtKB/TrEMBL
UniProt A0A8C0JYD9 ENTREZGENE
  A0A8I3Q1C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SE66_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42496 ENTREZGENE