FAT2 (FAT atypical cadherin 2) - Rat Genome Database

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Gene: FAT2 (FAT atypical cadherin 2) Canis lupus familiaris
Analyze
Symbol: FAT2
Name: FAT atypical cadherin 2
RGD ID: 12193527
Description: ENCODES a protein that exhibits cadherin binding (inferred); calcium ion binding (inferred); INVOLVED IN adherens junction organization (inferred); calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (inferred); cell adhesion (inferred); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN adherens junction (inferred); catenin complex (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FAT tumor suppressor homolog 2; protocadherin Fat 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,743,007 - 57,823,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,742,651 - 57,823,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,562,217 - 57,642,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,186,256 - 58,264,746 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,185,984 - 58,263,273 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,001,758 - 58,082,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,099,856 - 58,180,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,604,015 - 58,684,660 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,743,007 - 57,823,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,742,651 - 57,823,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,562,217 - 57,642,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,186,256 - 58,264,746 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,185,984 - 58,263,273 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,001,758 - 58,082,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,099,856 - 58,180,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,604,015 - 58,684,660 (+)NCBIUU_Cfam_GSD_1.0
FAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,504,092 - 151,594,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,504,092 - 151,591,331 (-)EnsemblGRCh38hg38GRCh38
GRCh375150,883,653 - 150,970,892 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,863,847 - 150,928,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 345150,863,846 - 150,928,698NCBI
Celera5146,965,062 - 147,029,916 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,029,050 - 146,093,922 (-)NCBIHuRef
CHM1_15150,316,083 - 150,380,950 (-)NCBICHM1_1
T2T-CHM13v2.05152,043,070 - 152,133,808 (-)NCBIT2T-CHM13v2.0
Fat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,141,435 - 55,228,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,141,435 - 55,227,390 (-)EnsemblGRCm39 Ensembl
GRCm381155,250,609 - 55,337,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,250,609 - 55,336,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,064,112 - 55,125,759 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,094,032 - 55,155,669 (-)NCBIMGSCv36mm8
Celera1159,839,223 - 59,900,066 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.5NCBI
Fat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,864,765 - 39,957,027 (-)NCBIGRCr8
mRatBN7.21039,364,072 - 39,456,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,364,073 - 39,456,216 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,051,017 - 44,140,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,541,102 - 43,630,456 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,044,810 - 39,134,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,583,025 - 40,682,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,584,403 - 40,657,861 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,421,638 - 40,513,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,648,951 - 40,749,409 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,662,573 - 40,763,032 (-)NCBI
Celera1038,701,431 - 38,790,574 (-)NCBICelera
Cytogenetic Map10q22NCBI
Fat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,941,800 - 6,033,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,944,236 - 6,033,776 (-)NCBIChiLan1.0ChiLan1.0
FAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,732,401 - 146,819,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,871,945 - 144,959,319 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,927,558 - 147,014,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,930,937 - 153,018,231 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,932,400 - 152,995,784 (-)Ensemblpanpan1.1panPan2
Fat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,682,713 - 112,751,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651511,132,059 - 11,199,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651511,132,059 - 11,200,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,469,847 - 71,530,501 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,448,491 - 71,531,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,676,229 - 77,761,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,064,687 - 54,152,696 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,064,393 - 54,152,416 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603423,577,450 - 23,643,131 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,433,349 - 37,520,756 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,427,330 - 37,520,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FAT2
1096 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 2 6
Below cutoff 3 5 22 6 6 6 6 12 8 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028363   ⟹   ENSCAFP00000026377
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl457,742,651 - 57,822,421 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049559   ⟹   ENSCAFP00000040284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl457,742,651 - 57,823,740 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845009368   ⟹   ENSCAFP00845007343
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl458,185,984 - 58,263,273 (+)Ensembl
RefSeq Acc Id: XM_038473884   ⟹   XP_038329812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1458,001,758 - 58,082,455 (+)NCBI
RefSeq Acc Id: XM_038534974   ⟹   XP_038390902
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0458,604,015 - 58,684,660 (+)NCBI
RefSeq Acc Id: XM_038599275   ⟹   XP_038455203
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0458,099,856 - 58,180,790 (+)NCBI
RefSeq Acc Id: XM_038663583   ⟹   XP_038519511
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0458,186,256 - 58,264,746 (+)NCBI
RefSeq Acc Id: XM_536461   ⟹   XP_536461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1457,743,007 - 57,823,740 (+)NCBI
Dog10K_Boxer_Tasha457,562,217 - 57,642,911 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_536461   ⟸   XM_536461
- UniProtKB: A0A8C0QBQ2 (UniProtKB/TrEMBL),   A0A8P0SLW4 (UniProtKB/TrEMBL),   A0A8C0QJR8 (UniProtKB/TrEMBL),   A0A8P0SUH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000040284   ⟸   ENSCAFT00000049559
RefSeq Acc Id: ENSCAFP00000026377   ⟸   ENSCAFT00000028363
RefSeq Acc Id: XP_038329812   ⟸   XM_038473884
RefSeq Acc Id: XP_038455203   ⟸   XM_038599275
RefSeq Acc Id: XP_038519511   ⟸   XM_038663583
- UniProtKB: A0A8I3MSP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390902   ⟸   XM_038534974
- UniProtKB: A0A8C0QJR8 (UniProtKB/TrEMBL),   A0A8P0SUH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007343   ⟸   ENSCAFT00845009368
Protein Domains
Cadherin   EGF-like   Laminin G

Promoters
RGD ID:13683016
Promoter ID:EPDNEW_C1082
Type:single initiation site
Name:FAT2_1
Description:FAT atypical cadherin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1457,743,047 - 57,743,107EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017871 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003715 UniProtKB/TrEMBL
  ENSCAFG00040007399 UniProtKB/TrEMBL
  ENSCAFG00845005247 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028363.6 UniProtKB/TrEMBL
  ENSCAFT00000049559.4 UniProtKB/TrEMBL
  ENSCAFT00030007052.1 UniProtKB/TrEMBL
  ENSCAFT00040013766.1 UniProtKB/TrEMBL
  ENSCAFT00040013847.1 UniProtKB/TrEMBL
  ENSCAFT00845009368 ENTREZGENE
  ENSCAFT00845009368.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
KEGG Report cfa:479323 UniProtKB/TrEMBL
NCBI Gene FAT2 ENTREZGENE
PANTHER CADHERIN-23 UniProtKB/TrEMBL
  CADHERIN-87A UniProtKB/TrEMBL
  NEURAL-CADHERIN 2-RELATED UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49313 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A8C0M4F2_CANLF UniProtKB/TrEMBL
  A0A8C0QBQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QJR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MSP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SLW4 ENTREZGENE
  A0A8P0SUH5 ENTREZGENE
UniProt Secondary A0A8P0SLW4 UniProtKB/TrEMBL
  A0A8P0SUH5 UniProtKB/TrEMBL
VGNC ID VGNC:40743 ENTREZGENE