ALPI (alkaline phosphatase, intestinal) - Rat Genome Database

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Gene: ALPI (alkaline phosphatase, intestinal) Canis lupus familiaris
Analyze
Symbol: ALPI
Name: alkaline phosphatase, intestinal
RGD ID: 12192371
Description: ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); magnesium ion binding (ortholog); protease binding (ortholog); INVOLVED IN cellular response to BMP stimulus (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Dysbiosis (ortholog); genetic disease (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 4-nitrophenyl phosphate; acetophenone; estrone
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkaline phosphatase, placental; ALPP; intestinal-type alkaline phosphatase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,107,418 - 44,110,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ALPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,107,418 - 44,110,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBIUU_Cfam_GSD_1.0
ALPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,456,153 - 232,460,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,456,125 - 232,460,753 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,320,863 - 233,325,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,029,077 - 233,032,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 342233,146,369 - 233,150,245NCBI
Celera2227,085,143 - 227,089,052 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2225,171,620 - 225,175,529 (+)NCBIHuRef
CHM1_12233,326,952 - 233,330,861 (+)NCBICHM1_1
T2T-CHM13v2.02232,942,959 - 232,947,559 (+)NCBIT2T-CHM13v2.0
Alpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,025,724 - 87,029,328 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,025,724 - 87,029,328 (-)EnsemblGRCm39 Ensembl
GRCm38187,098,002 - 87,101,606 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,098,002 - 87,101,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,994,579 - 88,998,181 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,929,175 - 88,932,777 (-)NCBIMGSCv36mm8
Celera190,070,193 - 90,073,795 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map144.05NCBI
Alpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,221,314 - 95,224,780 (-)NCBIGRCr8
mRatBN7.2987,773,411 - 87,776,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,773,411 - 87,776,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx996,197,663 - 96,201,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,333,414 - 101,336,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,701,666 - 99,705,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,197,616 - 94,201,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,197,618 - 94,201,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,922,817 - 93,926,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,892,887 - 85,896,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1986,076,305 - 86,079,772 (-)NCBI
Celera985,187,115 - 85,190,581 (-)NCBICelera
Cytogenetic Map9q35NCBI
ALPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213135,061,545 - 135,066,147 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B135,076,510 - 135,081,112 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B119,687,673 - 119,692,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B238,606,722 - 238,611,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B238,606,722 - 238,611,350 (+)Ensemblpanpan1.1panPan2
LOC101973915
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303186,319,789 - 186,323,568 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365254,616,212 - 4,619,932 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103218081
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110118,475,701 - 118,480,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10118,476,215 - 118,479,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604081,022,806 - 81,072,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248435,237,041 - 5,239,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALPI
59 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4
Low 1 5 14 2 6 1 12 8 7 1
Below cutoff 7 5 4 5 5 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845044518   ⟹   ENSCAFP00845034882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044640   ⟹   ENSCAFP00845034976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
RefSeq Acc Id: XM_038434590   ⟹   XP_038290518
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBI
RefSeq Acc Id: XM_038509670   ⟹   XP_038365598
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBI
RefSeq Acc Id: XM_038573026   ⟹   XP_038428954
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBI
RefSeq Acc Id: XM_038637283   ⟹   XP_038493211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBI
RefSeq Acc Id: XM_534605   ⟹   XP_534605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12544,107,418 - 44,110,947 (+)NCBI
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_534605   ⟸   XM_534605
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PK10 (UniProtKB/TrEMBL),   A0A8P0ND52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038365598   ⟸   XM_038509670
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038493211   ⟸   XM_038637283
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038290518   ⟸   XM_038434590
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PK10 (UniProtKB/TrEMBL),   A0A8P0ND52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038428954   ⟸   XM_038573026
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PK10 (UniProtKB/TrEMBL),   A0A8P0ND52 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845034882   ⟸   ENSCAFT00845044518
RefSeq Acc Id: ENSCAFP00845034976   ⟸   ENSCAFT00845044640


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011195 UniProtKB/TrEMBL
  ENSCAFG00845025234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017792.5 UniProtKB/TrEMBL
  ENSCAFT00000079486.2 UniProtKB/TrEMBL
  ENSCAFT00845044518 ENTREZGENE
  ENSCAFT00845044518.1 UniProtKB/TrEMBL
  ENSCAFT00845044640.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
NCBI Gene ALPI ENTREZGENE
PANTHER INTESTINAL-TYPE ALKALINE PHOSPHATASE UniProtKB/TrEMBL
  PTHR11596 UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/TrEMBL
PRINTS ALKPHPHTASE UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/TrEMBL
SMART alkPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
UniProt A0A8I3PK10 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PPF2_CANLF UniProtKB/TrEMBL
  A0A8P0ND52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TFC0_CANLF UniProtKB/TrEMBL