ALPI (alkaline phosphatase, intestinal) - Rat Genome Database

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Gene: ALPI (alkaline phosphatase, intestinal) Canis lupus familiaris
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Symbol: ALPI
Name: alkaline phosphatase, intestinal
RGD ID: 12192371
Description: ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); magnesium ion binding (ortholog); protease binding (ortholog); INVOLVED IN cellular response to BMP stimulus (ortholog); phosphorus metabolic process (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); Dysbiosis (ortholog); inflammatory bowel disease (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 4-nitrophenyl phosphate; acetophenone; estrone
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkaline phosphatase, placental; ALPP; intestinal-type alkaline phosphatase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,107,418 - 44,110,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBI
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBI
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBI
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBI
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
ALPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,107,418 - 44,110,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBI
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBI
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBI
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBI
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBI
ALPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,456,153 - 232,460,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2232,456,125 - 232,460,753 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,320,863 - 233,325,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,029,077 - 233,032,986 (+)NCBINCBI36hg18NCBI36
Build 342233,146,369 - 233,150,245NCBI
Celera2227,085,143 - 227,089,052 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2225,171,620 - 225,175,529 (+)NCBIHuRef
CHM1_12233,326,952 - 233,330,861 (+)NCBICHM1_1
T2T-CHM13v2.02232,942,959 - 232,947,559 (+)NCBI
Alpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,025,724 - 87,029,328 (-)NCBIGRCm39mm39
GRCm39 Ensembl187,025,724 - 87,029,328 (-)Ensembl
GRCm38187,098,002 - 87,101,606 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,098,002 - 87,101,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,994,579 - 88,998,181 (-)NCBIGRCm37mm9NCBIm37
MGSCv36188,929,175 - 88,932,777 (-)NCBImm8
Celera190,070,193 - 90,073,795 (-)NCBICelera
Cytogenetic Map1C5NCBI
Alpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2987,773,411 - 87,776,877 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl987,773,411 - 87,776,877 (-)Ensembl
Rnor_6.0994,197,616 - 94,201,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,197,618 - 94,201,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,922,817 - 93,926,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,892,887 - 85,896,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1986,076,305 - 86,079,772 (-)NCBI
Celera985,187,115 - 85,190,581 (-)NCBICelera
Cytogenetic Map9q35NCBI
ALPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B238,606,722 - 238,611,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B238,606,722 - 238,611,350 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B119,687,673 - 119,692,300 (+)NCBIMhudiblu_PPA_v0panPan3
LOC101973915
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303186,319,789 - 186,323,568 (+)NCBI
SpeTri2.0NW_0049365254,616,212 - 4,619,932 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103218081
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110118,475,701 - 118,480,391 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10118,476,215 - 118,479,499 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604081,022,806 - 81,072,279 (-)NCBIVero_WHO_p1.0
Alpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248435,237,041 - 5,239,806 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4
Low 1 5 14 2 6 1 12 8 7 1
Below cutoff 7 5 4 5 5 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845044518   ⟹   ENSCAFP00845034882
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044640   ⟹   ENSCAFP00845034976
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2544,365,568 - 44,369,594 (+)Ensembl
RefSeq Acc Id: XM_038434590   ⟹   XP_038290518
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02544,362,849 - 44,368,868 (+)NCBI
RefSeq Acc Id: XM_038509670   ⟹   XP_038365598
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12544,288,748 - 44,294,774 (+)NCBI
RefSeq Acc Id: XM_038573026   ⟹   XP_038428954
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02544,288,686 - 44,294,699 (+)NCBI
RefSeq Acc Id: XM_038637283   ⟹   XP_038493211
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02544,134,063 - 44,140,066 (+)NCBI
RefSeq Acc Id: XM_534605   ⟹   XP_534605
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12544,107,418 - 44,110,947 (+)NCBI
Dog10K_Boxer_Tasha2544,599,493 - 44,605,512 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_534605   ⟸   XM_534605
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038365598   ⟸   XM_038509670
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038493211   ⟸   XM_038637283
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038290518   ⟸   XM_038434590
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038428954   ⟸   XM_038573026
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845034882   ⟸   ENSCAFT00845044518
RefSeq Acc Id: ENSCAFP00845034976   ⟸   ENSCAFT00845044640

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
25 44107981 44107982 C T snv Siberian Husky (KKH2684)
25 44110148 44110149 A G snv Alpine Dachsbracke (AD009), Alaskan Malamute (AM007), Australian Shepherd (AU178), Berger Blanc Suisse (BB011), Border Collie (BC0480), Border Collie (BC272), Border Collie (BC485), Border Collie (BC518), Border Collie (BC555), Border Collie (BC597), Bearded Collie (BD016), Bearded Collie (BD052), Bearded Collie (BD085), Bearded Collie (BD089), Bearded Collie (BD091), Basset (BH003), Great Dane (DD116), Dachshund (DH0117), Dachshund (DH098), Doberman Pinscher (DO159), Chinese indigenous dogs (DQ10), Chinese indigenous dogs (DQ3), Chinese indigenous dogs (DQ4), Chinese indigenous dogs (DQ5), Chinese indigenous dogs (DQ7), German Shepherd/Mixed breed (DS032), German Shepherd/Mixed breed (DS041), German Shepherd/Mixed breed (DS042), German Shepherd (DS051), Elo (EL565), Golden Retriever (GR0855), Golden Retriever (GR0859), Golden Retriever (GR0860), Golden Retriever (GR1078), German Shepherd (GS1), German Shepherd (GS3), German Shepherd (GS4), German Shepherd (GS5), German Shepherd (GS6), German Shepherd (GS7), German Shepherd (GS8), German Wirehaired (GW004), Greyhound (GY432), Irish Terrier (IT0390), German Hunting Terrier (JT007), Jagdterrier (JT011), Kunming Dog (KM8), Kunming Dog (KM9), Labrador Retriever (LA1869), Labrador Retriever (LA882), Leonberger (LB111), Leonberger (LB1919), Chinese indigenous dogs (LJ4), Chinese indigenous dogs (LJ6), Chinese indigenous dogs (LJ7), Chinese indigenous dogs (LJ8), Landseer (LN048), Border Collie (LN47), Lagotto Romagnolo (LR1030), Lagotto Romagnolo (LR390), Lagotto Romagnolo (LR433), Lagotto Romagnolo (LR538), Lagotto Romagnolo (LR654), Malinois (MA008), Malinois (MA0163), Malinois (MA142), Malinois (MA324), Mixed Breed (MI016), Norwich Terrier (NW206), Norwich Terrier (NW255), Old English Sheepdog (OS001), Spanish Water Dog (PE002), Poodle (PL116), Rhodesian Ridgeback (RR098), Rhodesian Ridgeback (RR123), Rhodesian Ridgeback (RR224), Sloughi (SG005), Sloughi (SG006), Sloughi (SG008), Saluki (SL006), Great Lakes Wolf (SRS661486), Portuguese Wolf (SRS661492), Spanish Wolf (SRS661495), Yellowstone Wolf (SRS661496), Chinese Crested (SRS713815), Pembroke Welsh Corgi (SRS732551), Black Russian Terrier (SRS833812), Standard Poodle (SRS932143), Shetland Sheepdog (SS004), Airedale Terrier (TA001), Tibetan Mastiff (TM10), Tibetan Mastiff (TM2), Tibetan Mastiff (TM3), Tibetan Mastiff (TM4), Tibetan Mastiff (TM5), Tibetan Mastiff (TM6), Tibetan Mastiff (TM7), Tibetan Mastiff (TM8), Weimaraner (WE006), Weimaraner (WE008), Wolf (WO001_895), Wolf (WO002_732), Wolf (WO003_636), West Highland White Terrier (WW174), West Highland White Terrier (WW361), West Highland White Terrier (WW364), West Highland White Terrier (WW64), Chinese indigenous dogs (YJ2), Landseer (ZS14)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00845025234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845034882 ENTREZGENE
  ENSCAFP00845034882.1 UniProtKB/TrEMBL
  ENSCAFP00845034976.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845044518 ENTREZGENE
  ENSCAFT00845044518.1 UniProtKB/TrEMBL
  ENSCAFT00845044640.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
NCBI Gene ALPI ENTREZGENE
PANTHER PTHR11596 UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/TrEMBL
PRINTS ALKPHPHTASE UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/TrEMBL
SMART alkPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
UniProt A0A8I3PK10_CANLF UniProtKB/TrEMBL
  A0A8I3PPF2_CANLF UniProtKB/TrEMBL