LOC475399 (heterogeneous nuclear ribonucleoprotein C) - Rat Genome Database

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Gene: LOC475399 (heterogeneous nuclear ribonucleoprotein C) Canis lupus familiaris
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Symbol: LOC475399
Name: heterogeneous nuclear ribonucleoprotein C
RGD ID: 12191303
Description: ENCODES a protein that exhibits deaminase binding (ortholog); enzyme inhibitor activity (ortholog); identical protein binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); mRNA splicing, via spliceosome (ortholog); negative regulation of mRNA modification (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); atherosclerosis (ortholog); Autosomal Dominant Intellectual Developmental Disorder 74 (ortholog); FOUND IN actin cytoskeleton (ortholog); catalytic step 2 spliceosome (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heterogeneous nuclear ribonucleoprotein C (C1/C2); heterogeneous nuclear ribonucleoproteins C1/C2; HNRNPC; HNRPC
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: not annotated on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,239,810 - 18,299,065 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,724,388 - 18,783,435 (-)NCBIDog10K_Boxer_Tasha
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LOC475399
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,239,810 - 18,299,065 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,724,388 - 18,783,435 (-)NCBIDog10K_Boxer_Tasha
HNRNPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,209,147 - 21,269,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,209,136 - 21,269,494 (-)EnsemblGRCh38hg38GRCh38
GRCh371421,677,306 - 21,737,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,747,135 - 20,807,478 (-)NCBINCBI36Build 36hg18NCBI36
Build 341420,748,554 - 20,807,422NCBI
Celera141,537,857 - 1,598,198 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,797,516 - 1,858,479 (-)NCBIHuRef
CHM1_11421,679,085 - 21,739,357 (-)NCBICHM1_1
T2T-CHM13v2.01415,406,559 - 15,466,855 (-)NCBIT2T-CHM13v2.0
Hnrnpc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,310,834 - 52,341,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,310,834 - 52,341,485 (-)EnsemblGRCm39 Ensembl
GRCm381452,073,377 - 52,104,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,073,377 - 52,104,028 (-)EnsemblGRCm38mm10GRCm38
MGSCv371452,693,055 - 52,723,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,996,750 - 51,025,933 (-)NCBIMGSCv36mm8
Celera1449,053,955 - 49,085,339 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.79NCBI
Hnrnpc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,253,098 - 27,282,779 (-)NCBIGRCr8
mRatBN7.21524,779,593 - 24,809,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,779,450 - 24,809,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,550,657 - 27,580,436 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,506,410 - 28,536,024 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,759,342 - 26,788,962 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,486,605 - 28,517,353 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,486,617 - 28,517,353 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,296,829 - 32,327,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,516,839 - 27,546,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,532,538 - 27,562,346 (-)NCBI
Celera1525,083,705 - 25,113,041 (-)NCBICelera
Cytogenetic Map15p14NCBI
Hnrnpc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,949,975 - 2,002,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,949,975 - 2,002,297 (-)NCBIChiLan1.0ChiLan1.0
HNRNPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,660,425 - 22,721,136 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,877,303 - 21,937,623 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,022,280 - 2,083,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11420,103,594 - 20,163,824 (-)NCBIpanpan1.1PanPan1.1panPan2
Hnrnpc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,458,661 - 32,516,597 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936880368,041 - 425,967 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl777,921,145 - 77,973,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1777,921,098 - 77,978,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HNRNPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,677,871 - 21,737,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,678,559 - 21,731,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,696,803 - 24,758,618 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,205,292 - 7,276,889 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,198,387 - 7,276,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LOC475399
1000 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: XM_003432012   ⟹   XP_003432060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,299,048 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,783,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005629154   ⟹   XP_005629211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,293,114 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,777,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119468   ⟹   XP_013974943
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,293,114 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,777,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119469   ⟹   XP_013974944
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,299,065 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,783,435 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119470   ⟹   XP_013974945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,299,062 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,783,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119471   ⟹   XP_013974946
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,299,062 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,783,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119472   ⟹   XP_013974947
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,293,022 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,777,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119474   ⟹   XP_013974949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,293,114 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,777,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014119475   ⟹   XP_013974950
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,299,060 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,783,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022428103   ⟹   XP_022283811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,299,062 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,783,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022428104   ⟹   XP_022283812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,293,114 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,777,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038447260   ⟹   XP_038303188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1518,724,388 - 18,764,491 (-)NCBI
RefSeq Acc Id: XM_858338   ⟹   XP_863431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11518,239,810 - 18,293,114 (-)NCBI
Dog10K_Boxer_Tasha1518,724,388 - 18,777,480 (-)NCBI
Sequence:
RefSeq Acc Id: XP_013974950   ⟸   XM_014119475
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013974944   ⟸   XM_014119469
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003432060   ⟸   XM_003432012
- Peptide Label: isoform X6
- UniProtKB: A0A8I3PKW8 (UniProtKB/TrEMBL),   A0A8P0SYH4 (UniProtKB/TrEMBL),   A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013974946   ⟸   XM_014119471
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013974945   ⟸   XM_014119470
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013974949   ⟸   XM_014119474
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005629211   ⟸   XM_005629154
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013974943   ⟸   XM_014119468
- Peptide Label: isoform X1
- UniProtKB: A0A8P0TC86 (UniProtKB/TrEMBL),   A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013974947   ⟸   XM_014119472
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_863431   ⟸   XM_858338
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022283811   ⟸   XM_022428103
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022283812   ⟸   XM_022428104
- Peptide Label: isoform X7
- UniProtKB: A0A8C0NEI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038303188   ⟸   XM_038447260
- Peptide Label: isoform X3
- UniProtKB: A0A8C0KMQ8 (UniProtKB/TrEMBL)
Protein Domains
RRM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005504 UniProtKB/TrEMBL
  ENSCAFG00030014777 UniProtKB/TrEMBL
  ENSCAFG00845021389 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000066001.2 UniProtKB/TrEMBL
  ENSCAFT00000087258.2 UniProtKB/TrEMBL
  ENSCAFT00000106735.1 UniProtKB/TrEMBL
  ENSCAFT00030027271.1 UniProtKB/TrEMBL
  ENSCAFT00845037734.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro hnRNP_C UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
KEGG Report cfa:475399 UniProtKB/TrEMBL
NCBI Gene HNRNPC ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN UniProtKB/TrEMBL
  HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1/C2 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PIRSF hnRNP-C_Raly UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8C0KMQ8 ENTREZGENE
  A0A8C0NEI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PKW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PG44_CANLF UniProtKB/TrEMBL
  A0A8P0SYH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TC86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 LOC475399  heterogeneous nuclear ribonucleoprotein C  HNRNPC  heterogeneous nuclear ribonucleoprotein C  Symbol and/or name change 5135510 APPROVED
2019-07-16 HNRNPC  heterogeneous nuclear ribonucleoprotein C  HNRNPC  heterogeneous nuclear ribonucleoprotein C (C1/C2)  Symbol and/or name change 5135510 APPROVED