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Gene: ALPL (alkaline phosphatase, biomineralization associated) Canis lupus familiaris

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Symbol:

ALPL

Name:

alkaline phosphatase, biomineralization associated

RGD ID:

12191049

Description:

ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); INVOLVED IN cellular response to organic cyclic compound (ortholog); cementum mineralization (ortholog); developmental process involved in reproduction (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); adult hypophosphatasia (ortholog); alpha thalassemia-X-linked intellectual disability syndrome (ortholog); FOUND IN extracellular membrane-bounded organelle (ortholog); extracellular space (ortholog); mitochondrial intermembrane space (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme; ALP; tissue non-specific alkaline phosphatase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	77,559,791 - 77,614,102 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	77,559,791 - 77,614,820 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	74,073,609 - 74,088,831 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	78,128,381 - 78,182,495 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	78,128,381 - 78,182,455 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	74,947,430 - 74,962,684 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	75,958,433 - 75,973,647 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	76,961,389 - 76,976,632 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

adult hypophosphatasia (ISO)

alpha thalassemia-X-linked intellectual disability syndrome (ISO)

Alveolar Bone Loss (ISO)

Animal Disease Models (ISO)

arteriosclerosis (ISO)

calcinosis (ISO)

childhood hypophosphatasia (ISO)

congenital disorder of glycosylation Ir (ISO)

connective tissue disease (ISO)

familial combined hyperlipidemia (ISO)

genetic disease (ISO)

Germ Cell and Embryonal Neoplasms (ISO)

Heat Stroke (ISO)

Hypercholesterolemia (ISO)

hyperprolinemia type 2 (ISO)

hypophosphatasia (ISO)

in situ carcinoma (ISO)

infantile hypophosphatasia (ISO)

liver disease (ISO)

Metabolic Bone Diseases (ISO)

Metabolic Syndrome (ISO)

microcephaly (ISO)

MICROMELIA (ISO)

Odontohypophosphatasia (ISO)

osteochondrodysplasia (ISO)

osteogenesis imperfecta (ISO)

Parkinson's disease 6 (ISO)

Perinatal Lethal Hypophosphatasia (ISO)

secondary hyperparathyroidism (ISO)

steatotic liver disease (ISO)

uremia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (IEA)

calcium ion homeostasis (IEA)

cellular homeostasis (IEA)

cellular response to organic cyclic compound (IEA,ISO)

cementum mineralization (ISO)

chromatin looping (IEA)

chromatin remodeling (IEA)

developmental process involved in reproduction (IEA,ISO)

endochondral ossification (IEA,ISO)

futile creatine cycle (IEA)

inhibition of non-skeletal tissue mineralization (IEA)

phosphate ion homeostasis (IEA)

positive regulation of cold-induced thermogenesis (IEA)

pyridoxal phosphate metabolic process (IEA)

response to antibiotic (IEA,ISO)

response to glucocorticoid (ISO)

response to insulin (ISO)

response to lipopolysaccharide (ISO)

response to macrophage colony-stimulating factor (ISO)

response to sodium phosphate (IEA)

response to vitamin B6 (IEA)

response to vitamin D (IEA)

Cellular Component

extracellular matrix (IEA)

extracellular membrane-bounded organelle (IEA,ISO)

extracellular space (ISO)

mitochondrial intermembrane space (IEA,ISO)

mitochondrial membrane (IEA,ISO)

plasma membrane (IEA,ISO)

side of membrane (IEA)

Molecular Function

ADP phosphatase activity (IEA)

alkaline phosphatase activity (IEA,ISO)

ATP hydrolysis activity (IEA)

ATP-dependent H2AZ histone chaperone activity (IEA)

ATP-dependent H3-H4 histone complex chaperone activity (IEA)

calcium ion binding (IEA)

chromatin extrusion motor activity (IEA)

cohesin loader activity (IEA)

DNA clamp loader activity (IEA)

hydrolase activity (IEA)

inorganic diphosphate phosphatase activity (IEA)

metal ion binding (IEA)

phosphatase activity (IEA)

phosphoamidase activity (IEA)

phosphoethanolamine phosphatase activity (IEA)

protein binding (ISO)

pyridoxal phosphatase activity (IEA)

pyrophosphatase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

hypophosphatasia pathway (ISO)

vitamin B6 metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22022527	PMID:22296940	PMID:23734720	PMID:26426813	PMID:30032202	PMID:30700765

Genomics

Comparative Map Data

ALPL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	77,559,791 - 77,614,102 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	77,559,791 - 77,614,820 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	74,073,609 - 74,088,831 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	78,128,381 - 78,182,495 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	78,128,381 - 78,182,455 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	74,947,430 - 74,962,684 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	75,958,433 - 75,973,647 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	76,961,389 - 76,976,632 (-)	NCBI		UU_Cfam_GSD_1.0

ALPL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	21,508,984 - 21,578,410 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	21,509,397 - 21,578,410 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	21,835,477 - 21,904,903 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	21,708,445 - 21,777,492 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	21,581,174 - 21,650,208	NCBI
Celera	1	20,158,568 - 20,227,624 (+)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	20,079,620 - 20,148,672 (+)	NCBI		HuRef
CHM1_1	1	21,947,891 - 22,016,920 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	21,332,916 - 21,402,323 (+)	NCBI		T2T-CHM13v2.0

Alpl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	137,469,042 - 137,523,695 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	137,469,044 - 137,523,695 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	137,741,731 - 137,796,384 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	137,741,733 - 137,796,384 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	137,297,647 - 137,352,292 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	137,013,815 - 137,068,399 (-)	NCBI		MGSCv36	mm8
Celera	4	135,949,159 - 136,007,413 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.02	NCBI

Alpl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	155,234,770 - 155,289,785 (-)	NCBI		GRCr8
mRatBN7.2	5	149,951,397 - 150,006,424 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,951,409 - 150,006,446 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	152,647,183 - 152,702,235 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	154,421,476 - 154,476,524 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	154,403,485 - 154,458,535 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	156,086,496 - 156,141,513 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	156,086,497 - 156,141,537 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	159,841,916 - 159,897,391 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	156,501,739 - 156,558,727 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	156,511,778 - 156,568,766 (-)	NCBI
Celera	5	148,347,371 - 148,402,292 (-)	NCBI		Celera
RH 3.4 Map	5	1009.6	RGD
Cytogenetic Map	5	q36	NCBI

Alpl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	1,820,174 - 1,874,226 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	1,820,212 - 1,873,877 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALPL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	205,360,590 - 205,430,382 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	204,472,488 - 204,542,348 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	20,702,509 - 20,772,301 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	21,667,732 - 21,736,688 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	21,667,732 - 21,736,688 (+)	Ensembl	panpan1.1		panPan2

Alpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	41,362,174 - 41,405,120 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	7,209,093 - 7,229,989 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	7,209,196 - 7,229,899 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALPL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	79,589,045 - 79,649,644 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	79,589,695 - 79,649,646 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ALPL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	111,055,583 - 111,124,143 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	111,055,558 - 111,081,850 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	5,163,162 - 5,231,388 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alpl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	6,393,765 - 6,447,829 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	6,393,741 - 6,447,739 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ALPL
692 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001197137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005617212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005617213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005617214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038657712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038657713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF149417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF250846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000023578 ⟹ ENSCAFP00000021891

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	77,559,791 - 77,614,121 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000065521 ⟹ ENSCAFP00000054796

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	77,559,791 - 77,574,741 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000066819 ⟹ ENSCAFP00000065767

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	2	77,559,791 - 77,614,820 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845002711 ⟹ ENSCAFP00845002146

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	78,128,381 - 78,143,633 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845002716 ⟹ ENSCAFP00845002150

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	78,128,381 - 78,143,359 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845002731 ⟹ ENSCAFP00845002165

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	2	78,128,944 - 78,182,455 (-)	Ensembl

RefSeq Acc Id:

NM_001197137 ⟹ NP_001184066

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	2	77,559,791 - 77,575,015 (-)	NCBI
Dog10K_Boxer_Tasha	2	74,073,609 - 74,088,831 (-)	NCBI
ROS_Cfam_1.0	2	78,128,381 - 78,143,633 (-)	NCBI
UMICH_Zoey_3.1	2	74,947,430 - 74,962,684 (-)	NCBI
UNSW_CanFamBas_1.0	2	75,958,433 - 75,973,647 (-)	NCBI
UU_Cfam_GSD_1.0	2	76,961,389 - 76,976,632 (-)	NCBI

Sequence:

show sequence

GGAGAAGAAGGCCCAGGGTCCACAGGCTTGTTCAGAGGGTTGGACTGGCCTATGTCTGTCTACA
GACCAACGATGGCTGGCTGAGACAGCCCCGCTCCCTCCCCCAAGTCCAGGCAGCCCTGCCCTGC
CCTCAGGCATGAGAAGTTGGGGTATCTGTGATGTGTGGGGATGGGGAGCTGCCTCCCACCCCTG
CCAGATAACTGCCTCTCTGTCTATACAGAGAAAGAGAAAGACCCCAAGTATTGGAGAGACCAAG
CTCAACAGACCCTGAAATACGCCCTCAGGCTTCAGAATCTCAACACCAACGTGGCAAAGAATGT
CATCATGTTCCTGGGAGATGGGATGGGTGTCTCCACGGTGACGGCCACTCGCATCCTCAAGGGT
CAGCTCCACCACAACCCCGGGGAGGAGACCAGGCTGGAGATGGACAAGTTCCCTTACGTGGCCC
TCTCCAAGACATACAACACCAACGCTCAGGTCCCTGACAGCGCAGGCACTGCCACCGCCTACTT
GTGTGGAGTGAAGGCCAACGAGGGCACGGTGGGCGTGAGTGCCGCGACCCAGCGCACCCAGTGC
AACACGACTCAGGGAAACGAGGTCACCTCCATCCTGCGCTGGGCCAAGGACGCTGGGAAATCTG
TGGGCATAGTGACCACCACGAGGGTGAACCACGCCACCCCCAGTGCCGCCTACGCCCACTCCGC
TGACCGGGACTGGTACTCGGACAACGAGATGCCCCCGGAGGCCCTAAGCCAGGGCTGCAAGGAC
ATTGCCTACCAGCTCATGCACAACGTCAAGGACATCGAGGTGATCATGGGGGGCGGCCGGAAGT
ACATGTTCCCCAAGAATAGAACAGATGTGGAGTATGAGATGGACGAGAAGTCCAGGGGCACGAG
GCTGGATGGCCTGAACCTCATCGACATCTGGAAGAACTTCAAACCGAGACACAAGCACTCTCAC
TACGTCTGGAACCGCACGGAACTCCTGGCCCTCGACCCCTACACCGTGGACTACCTCTTGGGTC
TCTTTGAGCCGGGGGACATGCAGTACGAGCTGAACAGGAACAACGTGACTGACCCGTCACTCTC
CGAGATGGTGGAAATAGCCATCAAGATTCTGAGCAAGAACCCCAGAGGCTTCTTCTTGCTGGTG
GAAGGAGGCAGGATTGACCACGGGCATCACGAGGGCAAGGCCAAGCAGGCGCTGCACGAGGCAG
TGGAGATGGACCGGGCAATTGGGAAGGCAGGCGTCATGACCTCCTTGGAAGACACGCTGACCGT
CGTCACTGCGGACCACTCCCACGTCTTCACCTTTGGCGGGTACACCCCCCGGGGCAACTCTATC
TTTGGTCTGGCCCCCATGGTGAGTGACACGGACAAGAAGCCCTTCACGGCCATCCTGTATGGCA
ACGGGCCTGGCTACAAGGTGGTGGGCGGTGAGCGAGAGAACGTCTCCATGGTGGACTACGCTCA
CAACAACTACCAGGCGCAGTCCGCGGTGCCCCTGCGCCACGAGACCCACGGTGGGGAGGACGTA
GCAGTCTTCGCCAAGGGTCCCATGGCACACCTGCTGCACGGCGTCCACGAGCAGAACTACATCC
CCCACGTGATGGCTTATGCGGCCTGCATCGGTGCCAACCAGGACCACTGTGCCTCAGCCAGCTC
GGCAGGTGGCCCTTCTTCTCCAGGTCCCCTGCTCCTCCTGCTGGCCCTGCTCCCCGTGGGCATC
CTATTCTGAGGGCCCAGGACCTGGGCACCCACCACCTATGACAGATGGCCAGCCTCCCTCTCTC
AGTGCTGCCCACCGCCTGGGAGCCCACACCTCAAGGGCCAGGTAGGCGGAGGCCTTCACAGCCT
CTGCAGCTGCCAGAAAGAGGACCCAGGAAACCAAAGTCTGCTGCCCACCTCACTCCCCTCTGGA
ATCCTCCACCAGGGCCAGCCGAGTTCCTGGCCTCCGGCCTCCGCTCCCTCCCTGCTGCCCCCTT
TGGCCAACAGAGTAGGTTTCTCTCGGGCAGGCAGAGAATACAGACTGCAGAAATTCTCAAAGCA
TCTTATTTTTCTAGCAAACACATTTCTCCAGACCTGGAGGCCCCAGAGCTTCCATGGAACATTC
CGGATCTGACCTTCCCACTCCCCTCCCCTCCTGGAACCACCAGGCCCCATCATGCTAAGTCCCT
ACTGCAGGGGAGACCAGGTTCTCCACAGGAAGGGGATTTGCTCACTCATTCCAAGGCTGCCGGG
GGCTCCCAAGAAGTGAACTGGGACTGGCCATCCGACCCCAGGGCTTCCTGGGCTGGGAAGAGCA
GCAGCCTGGACAGACAGACATTTCTCAGCTCTTAACATGCATTGCCCACTCCTCTCTGAAGGAA
CACTCCTGTTTGGGACGGCAAAATTTTTTTCCCCTCTTTTTGGTGTTGGTTAAAAGGGAACACA
AAACATTTAAATAAAACTTTCCAAATATTTCTGAGGACAGAACTGAGTCTTTGTGGTCAGTGAG
GAAGAGAAAGAAACAAGCTTGTTTCTCTGGGAAGAGCTGGACTCTGGGCCAGGAGTGCCGGTTG
CGTCGGGCCGGGAGGAAGGGGCCGCCTGCTGACCTGGGGGCTTCAGCACTCCTTACCTGCGTGA
CTTTGGACAAAGTGCTTCGTGTCTCTGTGTCTCAGTTTTCTTAACCATAAAATGGGACACAATC
CAGTCCTGAGTTCTGTGAGAATCCAACAGAATGCCTCTGGGCCCTGAAACCCACAGCAAGAAAC
CCTCCCAGGGCCCTGTGACACCCTCACCGCACGGCGCCTACGCACAGAGACACATGGCCTGGCC
CAGTGGGGCTGTCTGATCATTCATTCATTCATTCATTCGACAAATCCCTTGACAACATGGGTTT
GAATGGCATGGATCCACTTATTTGCAGATTCTTTTGGATGAATACAGTTCTGTAACTGTATTTT
CCTTATGATTTTTAATATTTTCTTTCCTCTAGCTGACTTCATTGTAAGAATACAGTCTAGACTA
CATACAATATGCAAA

hide sequence

RefSeq Acc Id:

XM_038657712 ⟹ XP_038513640

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	2	78,128,933 - 78,182,495 (-)	NCBI

RefSeq Acc Id:

XM_038657713 ⟹ XP_038513641

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	2	78,128,933 - 78,157,978 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001184066	(Get FASTA)	NCBI Sequence Viewer
	XP_038513640	(Get FASTA)	NCBI Sequence Viewer
	XP_038513641	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD37431	(Get FASTA)	NCBI Sequence Viewer
	AAF64516	(Get FASTA)	NCBI Sequence Viewer
	AAN16382	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000021891.3
	ENSCAFP00000065767.2
	ENSCAFP00030006156.1
	ENSCAFP00030006185.1
	ENSCAFP00030006221.1
	ENSCAFP00040004784.1
	ENSCAFP00040004806.1
	ENSCAFP00040004822.1
	ENSCAFP00845002146
	ENSCAFP00845002146.1
	ENSCAFP00845002150.1
	ENSCAFP00845002165
	ENSCAFP00845002165.1

RefSeq Acc Id:

NP_001184066 ⟸ NM_001197137

- UniProtKB:

A0A8I3MZ80 (UniProtKB/TrEMBL), A0A8P0TH42 (UniProtKB/TrEMBL), Q8HZP7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSCLPPLPDNCLSVYTEKEKDPKYWRDQAQQTLKYALRLQNLNTNVAKNVIMFLGDGMGVSTV
TATRILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVS
AATQRTQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPE
ALSQGCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYEMDEKSRGTRLDGLNLIDIWKNF
KPRHKHSHYVWNRTELLALDPYTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEIAIKILSKN
PRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGKAGVMTSLEDTLTVVTADHSHVFTFGG
YTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRH
ETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANQDHCASASSAGGPSSPGPLLLL
LALLPVGILF

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Ensembl Acc Id:

ENSCAFP00000065767 ⟸ ENSCAFT00000066819

Ensembl Acc Id:

ENSCAFP00000021891 ⟸ ENSCAFT00000023578

Ensembl Acc Id:

ENSCAFP00000054796 ⟸ ENSCAFT00000065521

RefSeq Acc Id:	XP_038513640 ⟸ XM_038657712
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0QBL2 (UniProtKB/TrEMBL), A0A8C0KVD0 (UniProtKB/TrEMBL), A0A8I3MGB5 (UniProtKB/TrEMBL), Q8HZP7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038513641 ⟸ XM_038657713
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0QBL2 (UniProtKB/TrEMBL), A0A8C0KVD0 (UniProtKB/TrEMBL), A0A8I3MGB5 (UniProtKB/TrEMBL), Q8HZP7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845002150 ⟸ ENSCAFT00845002716

Ensembl Acc Id:

ENSCAFP00845002146 ⟸ ENSCAFT00845002711

Ensembl Acc Id:

ENSCAFP00845002165 ⟸ ENSCAFT00845002731

Promoters

RGD ID:

13682616

Promoter ID:

EPDNEW_C685

Type:

single initiation site

Name:

ALPL_1

Description:

alkaline phosphatase, liver/bone/kidney

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	2	77,614,032 - 77,614,092	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000014853	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030003722	UniProtKB/TrEMBL
	ENSCAFG00040002926	UniProtKB/TrEMBL
	ENSCAFG00845001491	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000023578.5	UniProtKB/TrEMBL
	ENSCAFT00000066819.2	UniProtKB/TrEMBL
	ENSCAFT00030007008.1	UniProtKB/TrEMBL
	ENSCAFT00030007054.1	UniProtKB/TrEMBL
	ENSCAFT00030007096.1	UniProtKB/TrEMBL
	ENSCAFT00040005560.1	UniProtKB/TrEMBL
	ENSCAFT00040005583.1	UniProtKB/TrEMBL
	ENSCAFT00040005600.1	UniProtKB/TrEMBL
	ENSCAFT00845002711	ENTREZGENE
	ENSCAFT00845002711.1	UniProtKB/TrEMBL
	ENSCAFT00845002716.1	UniProtKB/TrEMBL
	ENSCAFT00845002731	ENTREZGENE
	ENSCAFT00845002731.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.720.10	UniProtKB/TrEMBL
InterPro	Alkaline_phosphatase	UniProtKB/TrEMBL
	Alkaline_phosphatase_AS	UniProtKB/TrEMBL
	Alkaline_phosphatase_core_sf	UniProtKB/TrEMBL
KEGG Report	cfa:403548	UniProtKB/TrEMBL
NCBI Gene	ALPL	ENTREZGENE
PANTHER	ALKALINE PHOSPHATASE, TISSUE-NONSPECIFIC ISOZYME	UniProtKB/TrEMBL
	PTHR11596	UniProtKB/TrEMBL
Pfam	Alk_phosphatase	UniProtKB/TrEMBL
PRINTS	ALKPHPHTASE	UniProtKB/TrEMBL
PROSITE	ALKALINE_PHOSPHATASE	UniProtKB/TrEMBL
SMART	alkPPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53649	UniProtKB/TrEMBL
UniProt	A0A8C0KVD0	ENTREZGENE
	A0A8C0M832_CANLF	UniProtKB/TrEMBL
	A0A8C0QBL2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RC26_CANLF	UniProtKB/TrEMBL
	A0A8I3MGB5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MPW8_CANLF	UniProtKB/TrEMBL
	A0A8I3MZ80	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TH42	ENTREZGENE, UniProtKB/TrEMBL
	Q8HZP7	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:37818	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-10-30	ALPL	alkaline phosphatase, biomineralization associated		alkaline phosphatase, liver/bone/kidney	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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