ALPL (alkaline phosphatase, biomineralization associated) - Rat Genome Database

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Gene: ALPL (alkaline phosphatase, biomineralization associated) Canis lupus familiaris
Analyze
Symbol: ALPL
Name: alkaline phosphatase, biomineralization associated
RGD ID: 12191049
Description: ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); phosphoamidase activity (ortholog); pyrophosphatase activity (ortholog); INVOLVED IN cellular response to organic cyclic compound (ortholog); cementum mineralization (ortholog); developmental process involved in reproduction (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH adult hypophosphatasia (ortholog); Alveolar Bone Loss (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular matrix (ortholog); extracellular membrane-bounded organelle (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme; ALP; tissue non-specific alkaline phosphatase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,559,791 - 77,614,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBI
ROS_Cfam_1.0278,128,381 - 78,182,495 (-)NCBI
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBI
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBI
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22022527   PMID:22296940   PMID:23734720   PMID:26426813   PMID:30700765  


Genomics

Comparative Map Data
ALPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,559,791 - 77,614,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBI
ROS_Cfam_1.0278,128,381 - 78,182,495 (-)NCBI
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBI
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBI
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBI
ALPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl121,509,397 - 21,578,410 (+)EnsemblGRCh38hg38GRCh38
GRCh38121,508,984 - 21,578,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37121,835,477 - 21,904,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,708,445 - 21,777,492 (+)NCBINCBI36hg18NCBI36
Build 34121,581,174 - 21,650,208NCBI
Celera120,158,568 - 20,227,624 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,079,620 - 20,148,672 (+)NCBIHuRef
CHM1_1121,947,891 - 22,016,920 (+)NCBICHM1_1
Alpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,469,042 - 137,523,695 (-)NCBIGRCm39mm39
GRCm39 Ensembl4137,469,044 - 137,523,695 (-)Ensembl
GRCm384137,741,731 - 137,796,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,741,733 - 137,796,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,297,647 - 137,352,292 (-)NCBIGRCm37mm9NCBIm37
MGSCv364137,013,815 - 137,068,399 (-)NCBImm8
Celera4135,949,159 - 136,007,413 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
Alpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,951,397 - 150,006,424 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5149,951,409 - 150,006,446 (-)Ensembl
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
Alpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,820,174 - 1,874,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,820,212 - 1,873,877 (+)NCBIChiLan1.0ChiLan1.0
ALPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1121,667,732 - 21,736,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,667,732 - 21,736,688 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0120,702,509 - 20,772,301 (+)NCBIMhudiblu_PPA_v0panPan3
Alpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,362,174 - 41,405,120 (+)NCBI
SpeTri2.0NW_0049364747,209,196 - 7,229,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,588,659 - 79,649,648 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,055,583 - 111,124,143 (-)NCBI
ChlSab1.1 Ensembl20111,055,558 - 111,081,850 (-)Ensembl
Vero_WHO_p1.0NW_0236660335,163,162 - 5,231,388 (+)NCBI
Alpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 3 3 1 10 5
Low 5 5 12 3 2 3 5 2 2 8 5 3
Below cutoff 4 4 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023578   ⟹   ENSCAFP00000021891
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,559,791 - 77,614,121 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000065521   ⟹   ENSCAFP00000054796
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,559,791 - 77,574,741 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000066819   ⟹   ENSCAFP00000065767
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)Ensembl
RefSeq Acc Id: NM_001197137   ⟹   NP_001184066
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,559,791 - 77,575,015 (-)NCBI
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBI
ROS_Cfam_1.0278,128,381 - 78,143,633 (-)NCBI
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBI
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBI
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005617212   ⟹   XP_005617269
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,560,344 - 77,588,947 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005617213   ⟹   XP_005617270
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,560,344 - 77,589,347 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005617214   ⟹   XP_005617271
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,560,344 - 77,614,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038657712   ⟹   XP_038513640
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0278,128,933 - 78,182,495 (-)NCBI
RefSeq Acc Id: XM_038657713   ⟹   XP_038513641
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0278,128,933 - 78,157,978 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001184066 (Get FASTA)   NCBI Sequence Viewer  
  XP_038513640 (Get FASTA)   NCBI Sequence Viewer  
  XP_038513641 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD37431 (Get FASTA)   NCBI Sequence Viewer  
  AAF64516 (Get FASTA)   NCBI Sequence Viewer  
  AAN16382 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001184066   ⟸   NM_001197137
- Sequence:
RefSeq Acc Id: XP_005617271   ⟸   XM_005617214
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005617270   ⟸   XM_005617213
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005617269   ⟸   XM_005617212
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000065767   ⟸   ENSCAFT00000066819
RefSeq Acc Id: ENSCAFP00000021891   ⟸   ENSCAFT00000023578
RefSeq Acc Id: ENSCAFP00000054796   ⟸   ENSCAFT00000065521
RefSeq Acc Id: XP_038513640   ⟸   XM_038657712
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513641   ⟸   XM_038657713
- Peptide Label: isoform X1

Promoters
RGD ID:13682616
Promoter ID:EPDNEW_C685
Type:single initiation site
Name:ALPL_1
Description:alkaline phosphatase, liver/bone/kidney
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,614,032 - 77,614,092EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014853 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000054796 ENTREZGENE
Ensembl Transcript ENSCAFT00000065521 ENTREZGENE
NCBI Gene ALPL ENTREZGENE
VGNC ID VGNC:37818 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-30 ALPL  alkaline phosphatase, biomineralization associated    alkaline phosphatase, liver/bone/kidney  Symbol and/or name change 5135510 APPROVED