HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase) - Rat Genome Database

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Gene: HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase) Canis lupus familiaris
Analyze
Symbol: HGSNAT
Name: heparan-alpha-glucosaminide N-acetyltransferase
RGD ID: 12188083
Description: ENCODES a protein that exhibits acyltransferase activity (ortholog); heparan-alpha-glucosaminide N-acetyltransferase activity (ortholog); INVOLVED IN heparan sulfate proteoglycan catabolic process (ortholog); protein complex oligomerization (ortholog); ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy type A12 (ortholog); epilepsy (ortholog); fundus dystrophy (ortholog); FOUND IN lysosomal lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11622,640,912 - 22,683,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1622,642,289 - 22,683,879 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,146,111 - 23,188,937 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01624,392,606 - 24,435,430 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1624,392,606 - 24,435,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11622,760,972 - 22,803,889 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,325,689 - 23,368,698 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01623,376,944 - 23,419,965 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17033958   PMID:30032202  


Genomics

Comparative Map Data
HGSNAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11622,640,912 - 22,683,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1622,642,289 - 22,683,879 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,146,111 - 23,188,937 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01624,392,606 - 24,435,430 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1624,392,606 - 24,435,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11622,760,972 - 22,803,889 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,325,689 - 23,368,698 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01623,376,944 - 23,419,965 (-)NCBIUU_Cfam_GSD_1.0
HGSNAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38843,140,464 - 43,202,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl843,140,464 - 43,202,855 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,995,607 - 43,057,998 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36843,114,749 - 43,177,127 (+)NCBINCBI36Build 36hg18NCBI36
Celera841,950,967 - 42,005,677 (+)NCBICelera
Cytogenetic Map8p11.21-p11.1NCBI
HuRef841,518,326 - 41,580,566 (+)NCBIHuRef
CHM1_1843,042,515 - 43,105,151 (+)NCBICHM1_1
T2T-CHM13v2.0843,409,397 - 43,471,962 (+)NCBIT2T-CHM13v2.0
Hgsnat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,432,495 - 26,466,704 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,434,481 - 26,466,781 (-)EnsemblGRCm39 Ensembl
GRCm38825,944,459 - 25,976,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,944,453 - 25,976,753 (-)EnsemblGRCm38mm10GRCm38
MGSCv37827,054,931 - 27,087,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,410,004 - 27,412,027 (-)NCBIMGSCv36mm8
Celera827,412,295 - 27,443,966 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.22NCBI
Hgsnat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,807,967 - 72,840,180 (+)NCBIGRCr8
mRatBN7.21666,105,233 - 66,137,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,105,181 - 66,136,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,384,094 - 71,416,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,790,423 - 74,822,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,030,536 - 70,062,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01670,876,557 - 70,909,443 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,540,794 - 70,572,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,511,545 - 70,513,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1664,016,244 - 64,048,685 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
Hgsnat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,349,213 - 13,387,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545713,351,963 - 13,386,521 (+)NCBIChiLan1.0ChiLan1.0
HGSNAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2761,597,533 - 61,657,575 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1837,313,523 - 37,373,552 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0842,388,406 - 42,448,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,832,143 - 39,888,948 (+)NCBIpanpan1.1PanPan1.1panPan2
Hgsnat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494345,659,294 - 45,699,457 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570258,820 - 297,762 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570257,636 - 297,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100154844
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1178,644,388 - 8,665,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2179,522,494 - 9,545,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HGSNAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1841,146,280 - 41,196,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl841,146,483 - 41,197,518 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666052551,844 - 602,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hgsnat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624992101,546 - 153,599 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462499286,403 - 153,100 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HGSNAT
661 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 22 6 2 6 6 1 12 10 6
Low 1 4 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008654   ⟹   ENSCAFP00000008021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1622,642,558 - 22,683,879 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082749   ⟹   ENSCAFP00000066504
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1622,642,289 - 22,683,879 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083998   ⟹   ENSCAFP00000065077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1622,642,558 - 22,683,879 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029262   ⟹   ENSCAFP00845023014
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1624,392,606 - 24,435,665 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029394   ⟹   ENSCAFP00845023102
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1624,392,606 - 24,435,665 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029509   ⟹   ENSCAFP00845023181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1624,392,606 - 24,435,665 (-)Ensembl
RefSeq Acc Id: XM_038452395   ⟹   XP_038308323
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1623,146,111 - 23,188,845 (-)NCBI
RefSeq Acc Id: XM_038497443   ⟹   XP_038353371
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11622,760,972 - 22,803,889 (-)NCBI
RefSeq Acc Id: XM_038497444   ⟹   XP_038353372
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11622,760,972 - 22,803,797 (-)NCBI
RefSeq Acc Id: XM_038559899   ⟹   XP_038415827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01623,376,944 - 23,419,965 (-)NCBI
RefSeq Acc Id: XM_038559900   ⟹   XP_038415828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01623,376,944 - 23,419,873 (-)NCBI
RefSeq Acc Id: XM_038623926   ⟹   XP_038479854
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01623,325,689 - 23,368,698 (-)NCBI
RefSeq Acc Id: XM_038623927   ⟹   XP_038479855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01623,325,689 - 23,368,606 (-)NCBI
RefSeq Acc Id: XM_038689687   ⟹   XP_038545615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01624,392,606 - 24,435,430 (-)NCBI
RefSeq Acc Id: XM_038689688   ⟹   XP_038545616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01624,392,606 - 24,435,338 (-)NCBI
RefSeq Acc Id: XM_539948   ⟹   XP_539948
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11622,640,912 - 22,683,733 (-)NCBI
Dog10K_Boxer_Tasha1623,146,111 - 23,188,937 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_539948   ⟸   XM_539948
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SU37 (UniProtKB/TrEMBL),   A0A8I3P2G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000065077   ⟸   ENSCAFT00000083998
RefSeq Acc Id: ENSCAFP00000008021   ⟸   ENSCAFT00000008654
RefSeq Acc Id: ENSCAFP00000066504   ⟸   ENSCAFT00000082749
RefSeq Acc Id: XP_038353371   ⟸   XM_038497443
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038353372   ⟸   XM_038497444
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038479854   ⟸   XM_038623926
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479855   ⟸   XM_038623927
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038545615   ⟸   XM_038689687
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SU37 (UniProtKB/TrEMBL),   A0A8I3P2G0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038545616   ⟸   XM_038689688
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SU37 (UniProtKB/TrEMBL),   A0A8I3P2G0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308323   ⟸   XM_038452395
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SU37 (UniProtKB/TrEMBL),   A0A8I3P2G0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415827   ⟸   XM_038559899
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SU37 (UniProtKB/TrEMBL),   A0A8I3P2G0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415828   ⟸   XM_038559900
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SU37 (UniProtKB/TrEMBL),   A0A8I3P2G0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845023181   ⟸   ENSCAFT00845029509
RefSeq Acc Id: ENSCAFP00845023102   ⟸   ENSCAFT00845029394
RefSeq Acc Id: ENSCAFP00845023014   ⟸   ENSCAFT00845029262
Protein Domains
Heparan-alpha-glucosaminide N-acetyltransferase

Promoters
RGD ID:13686080
Promoter ID:EPDNEW_C4148
Type:initiation region
Name:HGSNAT_1
Description:heparan-alpha-glucosaminide N-acetyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11622,683,723 - 22,683,783EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005378 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040016721 UniProtKB/TrEMBL
  ENSCAFG00845016487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008654.5 UniProtKB/TrEMBL
  ENSCAFT00040030890.1 UniProtKB/TrEMBL
  ENSCAFT00845029262 ENTREZGENE
  ENSCAFT00845029262.1 UniProtKB/TrEMBL
  ENSCAFT00845029394.1 UniProtKB/TrEMBL
  ENSCAFT00845029509.1 UniProtKB/TrEMBL
InterPro HGSNAT_cat UniProtKB/TrEMBL
NCBI Gene HGSNAT ENTREZGENE
PANTHER HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE UniProtKB/TrEMBL
  LD22376P UniProtKB/TrEMBL
Pfam DUF1624 UniProtKB/TrEMBL
UniProt A0A8C0SU37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NVK6_CANLF UniProtKB/TrEMBL
  A0A8I3P2G0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RZD7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41678 ENTREZGENE