ACSM3 (acyl-CoA synthetase medium chain family member 3) - Rat Genome Database

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Gene: ACSM3 (acyl-CoA synthetase medium chain family member 3) Canis lupus familiaris
Analyze
Symbol: ACSM3
Name: acyl-CoA synthetase medium chain family member 3
RGD ID: 12184558
Description: ENCODES a protein that exhibits acid-thiol ligase activity (inferred); butyrate-CoA ligase activity (inferred); CoA-ligase activity (inferred); INVOLVED IN fatty acid biosynthetic process (ortholog); PARTICIPATES IN fatty acid beta degradation pathway; ASSOCIATED WITH genetic disease (ortholog); hypertension (ortholog); IgA glomerulonephritis (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acyl-CoA synthetase medium-chain family member 3; acyl-coenzyme A synthetase ACSM3, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,558,010 - 24,594,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,558,142 - 24,582,728 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha622,794,570 - 22,815,828 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0624,713,351 - 24,738,717 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl624,713,760 - 24,738,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,514,283 - 24,539,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,409,510 - 24,434,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0624,793,586 - 24,812,573 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ACSM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,558,010 - 24,594,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,558,142 - 24,582,728 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha622,794,570 - 22,815,828 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0624,713,351 - 24,738,717 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl624,713,760 - 24,738,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,514,283 - 24,539,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,409,510 - 24,434,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0624,793,586 - 24,812,573 (-)NCBIUU_Cfam_GSD_1.0
ACSM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381620,674,405 - 20,797,581 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1620,610,243 - 20,797,581 (+)EnsemblGRCh38hg38GRCh38
GRCh371620,775,336 - 20,808,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361620,682,813 - 20,715,980 (+)NCBINCBI36Build 36hg18NCBI36
Build 341620,682,812 - 20,715,979NCBI
Celera1620,085,531 - 20,118,378 (+)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1619,310,909 - 19,343,750 (+)NCBIHuRef
CHM1_11620,862,551 - 20,895,398 (+)NCBICHM1_1
T2T-CHM13v2.01620,605,311 - 20,728,512 (+)NCBIT2T-CHM13v2.0
Acsm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,360,106 - 119,384,119 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,360,146 - 119,386,736 (+)EnsemblGRCm39 Ensembl
GRCm387119,760,883 - 119,784,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7119,760,923 - 119,787,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv377126,904,437 - 126,928,410 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,552,072 - 119,576,045 (+)NCBIMGSCv36mm8
Celera7119,680,775 - 119,704,303 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map764.17NCBI
Acsm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,564,652 - 183,591,328 (+)NCBIGRCr8
mRatBN7.21174,133,260 - 174,159,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,133,288 - 174,160,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,448,828 - 182,475,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,634,871 - 189,661,572 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,371,819 - 182,397,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,514,504 - 189,541,233 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,514,553 - 189,541,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,449,042 - 196,475,596 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41178,054,386 - 178,081,751 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11178,212,017 - 178,214,310 (+)NCBI
Celera1171,883,756 - 171,910,443 (+)NCBICelera
Cytogenetic Map1q35NCBI
Acsm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495549372,633 - 96,348 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495549373,306 - 95,521 (+)NCBIChiLan1.0ChiLan1.0
ACSM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,917,691 - 21,964,777 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,438,183 - 26,485,179 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,611,715 - 17,644,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11620,796,425 - 20,829,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1620,796,425 - 20,829,315 (+)Ensemblpanpan1.1panPan2
Acsm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344117,980,363 - 117,997,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365016,078,219 - 6,095,538 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365016,077,366 - 6,095,432 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,247,725 - 25,283,709 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1325,247,723 - 25,284,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,031,989 - 26,068,440 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACSM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1518,876,390 - 18,929,914 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl518,904,110 - 18,929,729 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606810,973,567 - 11,023,810 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247826,930,505 - 6,959,069 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247826,930,461 - 6,958,867 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACSM3
316 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 6 6
Low 3 4 7 6 2 8 10
Below cutoff 2 1 9 6 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028541   ⟹   ENSCAFP00000026547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl624,558,142 - 24,582,728 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013482   ⟹   ENSCAFP00845010459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl624,713,760 - 24,738,638 (-)Ensembl
RefSeq Acc Id: XM_005621465   ⟹   XP_005621522
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1624,558,010 - 24,576,985 (-)NCBI
Dog10K_Boxer_Tasha622,800,402 - 22,815,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038478927   ⟹   XP_038334855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1624,514,283 - 24,539,642 (-)NCBI
RefSeq Acc Id: XM_038478928   ⟹   XP_038334856
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1624,514,283 - 24,533,800 (-)NCBI
RefSeq Acc Id: XM_038540171   ⟹   XP_038396099
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0624,793,586 - 24,812,573 (-)NCBI
RefSeq Acc Id: XM_038604257   ⟹   XP_038460185
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0624,409,510 - 24,434,851 (-)NCBI
RefSeq Acc Id: XM_038604258   ⟹   XP_038460186
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0624,409,510 - 24,429,022 (-)NCBI
RefSeq Acc Id: XM_038668972   ⟹   XP_038524900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0624,713,351 - 24,738,717 (-)NCBI
RefSeq Acc Id: XM_038668973   ⟹   XP_038524901
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0624,713,351 - 24,732,873 (-)NCBI
RefSeq Acc Id: XM_846027   ⟹   XP_851120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1624,558,010 - 24,594,326 (-)NCBI
Dog10K_Boxer_Tasha622,794,570 - 22,815,828 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_851120   ⟸   XM_846027
- Peptide Label: isoform X3
- UniProtKB: A0A8P0NJ98 (UniProtKB/TrEMBL),   A0A8C0LYG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005621522   ⟸   XM_005621465
- Peptide Label: isoform X3
- UniProtKB: A0A8P0NJ98 (UniProtKB/TrEMBL),   A0A8C0LYG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026547   ⟸   ENSCAFT00000028541
RefSeq Acc Id: XP_038334855   ⟸   XM_038478927
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038334856   ⟸   XM_038478928
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460185   ⟸   XM_038604257
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460186   ⟸   XM_038604258
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038524900   ⟸   XM_038668972
- Peptide Label: isoform X1
- UniProtKB: A0A8I3N6J5 (UniProtKB/TrEMBL),   A0A8C0LYG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524901   ⟸   XM_038668973
- Peptide Label: isoform X1
- UniProtKB: A0A8I3N6J5 (UniProtKB/TrEMBL),   A0A8C0LYG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396099   ⟸   XM_038540171
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LYG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010459   ⟸   ENSCAFT00845013482
Protein Domains
AMP-binding enzyme C-terminal   AMP-dependent synthetase/ligase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017952 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000533 UniProtKB/TrEMBL
  ENSCAFG00040000287 UniProtKB/TrEMBL
  ENSCAFG00845007639 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028541.5 UniProtKB/TrEMBL
  ENSCAFT00030000906.1 UniProtKB/TrEMBL
  ENSCAFT00040000517.1 UniProtKB/TrEMBL
  ENSCAFT00845013482 ENTREZGENE
  ENSCAFT00845013482.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/TrEMBL
InterPro AMP-bd_C UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/TrEMBL
KEGG Report cfa:608888 UniProtKB/TrEMBL
NCBI Gene ACSM3 ENTREZGENE
PANTHER ACYL-COENZYME A SYNTHETASE UniProtKB/TrEMBL
  ACYL-COENZYME A SYNTHETASE ACSM3, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/TrEMBL
  AMP-binding_C UniProtKB/TrEMBL
PROSITE AMP_BINDING UniProtKB/TrEMBL
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A0A8C0LYG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N6J5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NJ98 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54007 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 ACSM3  acyl-CoA synthetase medium chain family member 3    acyl-CoA synthetase medium-chain family member 3  Symbol and/or name change 5135510 APPROVED