RPE65 (retinoid isomerohydrolase RPE65) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: RPE65 (retinoid isomerohydrolase RPE65) Canis lupus familiaris
Analyze
Symbol: RPE65
Name: retinoid isomerohydrolase RPE65
RGD ID: 12183779
Description: ENCODES a protein that exhibits all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity; all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity (ortholog); cardiolipin binding (ortholog); INVOLVED IN retinoid metabolic process; camera-type eye development (ortholog); circadian rhythm (ortholog); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoid cycle metabolic pathway; ASSOCIATED WITH Leber congenital amaurosis 2; adrenocorticotropic hormone deficiency (ortholog); autistic disorder (ortholog); FOUND IN cell body (ortholog); endoplasmic reticulum membrane (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium abundant protein RPE65; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; retinoid isomerohydrolase; retinol isomerase; rpe65 gene for retinal pigment epithelium-specific protein; RPE65, retinoid isomerohydrolase; truncated RPE65
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1676,887,399 - 76,911,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl676,887,399 - 76,911,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha679,498,666 - 79,521,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,481,101 - 77,504,927 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,481,101 - 77,504,925 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,031,835 - 77,055,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0676,935,191 - 76,959,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,422,281 - 77,446,314 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9808841   PMID:10191083   PMID:14627956   PMID:16150724   PMID:16502306   PMID:17960118   PMID:18188938   PMID:20671290   PMID:20837787   PMID:22951453   PMID:30032202   PMID:33435495  


Genomics

Comparative Map Data
RPE65
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1676,887,399 - 76,911,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl676,887,399 - 76,911,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha679,498,666 - 79,521,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,481,101 - 77,504,927 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,481,101 - 77,504,925 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,031,835 - 77,055,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0676,935,191 - 76,959,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,422,281 - 77,446,314 (+)NCBIUU_Cfam_GSD_1.0
RPE65
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,428,822 - 68,449,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,428,822 - 68,451,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37168,894,505 - 68,915,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,667,095 - 68,688,230 (-)NCBINCBI36Build 36hg18NCBI36
Build 34168,606,465 - 68,627,663NCBI
Celera167,184,748 - 67,205,854 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef167,004,313 - 67,025,452 (-)NCBIHuRef
CHM1_1169,009,866 - 69,031,001 (-)NCBICHM1_1
T2T-CHM13v2.0168,306,207 - 68,327,339 (-)NCBIT2T-CHM13v2.0
Rpe65
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393159,304,712 - 159,330,944 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3159,304,812 - 159,330,958 (+)EnsemblGRCm39 Ensembl
GRCm383159,599,075 - 159,625,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3159,599,175 - 159,625,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv373159,262,145 - 159,288,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363159,534,526 - 159,560,092 (+)NCBIMGSCv36mm8
Celera3166,038,618 - 166,064,587 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map382.52NCBI
Rpe65
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82251,425,228 - 251,457,209 (+)NCBIGRCr8
mRatBN7.22248,766,497 - 248,798,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2248,766,612 - 248,798,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2256,482,408 - 256,514,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02254,375,936 - 254,407,703 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02249,342,889 - 249,374,020 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02266,141,581 - 266,169,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2266,141,581 - 266,169,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02284,774,159 - 284,804,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.12257,860,998 - 257,893,921 (+)NCBI
Celera2240,512,281 - 240,537,640 (+)NCBICelera
Cytogenetic Map2q45NCBI
Rpe65
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,183,937 - 23,208,282 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,184,326 - 23,208,206 (+)NCBIChiLan1.0ChiLan1.0
RPE65
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21158,421,347 - 158,442,454 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11157,581,121 - 157,602,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,666,784 - 67,687,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,623,775 - 69,644,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,623,775 - 69,644,904 (-)Ensemblpanpan1.1panPan2
Rpe65
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505881,055,133 - 81,142,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365913,347,272 - 3,368,015 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365913,347,346 - 3,368,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPE65
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,206,078 - 144,229,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,206,078 - 144,229,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26133,491,901 - 133,514,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPE65
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12064,662,777 - 64,684,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2064,664,358 - 64,683,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603352,929,980 - 52,950,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpe65
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,302,453 - 27,319,203 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,302,222 - 27,319,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RPE65
445 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
5 5 1 11 13 14 6 5 6 4 19 8 5 10 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ899954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000032537   ⟹   ENSCAFP00000030301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl676,887,399 - 76,911,131 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845024324   ⟹   ENSCAFP00845019110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,481,101 - 77,504,925 (+)Ensembl
RefSeq Acc Id: NM_001003176   ⟹   NP_001003176
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1676,887,399 - 76,911,133 (+)NCBI
Dog10K_Boxer_Tasha679,498,666 - 79,521,615 (+)NCBI
ROS_Cfam_1.0677,481,101 - 77,504,927 (+)NCBI
UMICH_Zoey_3.1677,031,835 - 77,055,739 (+)NCBI
UNSW_CanFamBas_1.0676,935,191 - 76,959,205 (+)NCBI
UU_Cfam_GSD_1.0677,422,281 - 77,446,314 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001003176   ⟸   NM_001003176
- UniProtKB: O97623 (UniProtKB/Swiss-Prot),   Q8MJY9 (UniProtKB/Swiss-Prot),   Q9TVB8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSCAFP00000030301   ⟸   ENSCAFT00000032537
Ensembl Acc Id: ENSCAFP00845019110   ⟸   ENSCAFT00845024324


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020431 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014298 UniProtKB/TrEMBL
  ENSCAFG00040002109 UniProtKB/TrEMBL
  ENSCAFG00845013646 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000032537.5 UniProtKB/TrEMBL
  ENSCAFT00030026465.1 UniProtKB/TrEMBL
  ENSCAFT00040004026.1 UniProtKB/TrEMBL
  ENSCAFT00845024324 ENTREZGENE
  ENSCAFT00845024324.1 UniProtKB/TrEMBL
InterPro Carotenoid_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403803 UniProtKB/Swiss-Prot
NCBI Gene RPE65 ENTREZGENE
PANTHER PTHR10543 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINOID ISOMEROHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RPE65 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0RK19_CANLF UniProtKB/TrEMBL
  A0A8I3NEZ4_CANLF UniProtKB/TrEMBL
  O97623 ENTREZGENE
  Q8MIH5_CANLF UniProtKB/TrEMBL
  Q8MJY9 ENTREZGENE
  Q9TVB8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O97623 UniProtKB/Swiss-Prot
  Q8MJY9 UniProtKB/Swiss-Prot
VGNC ID VGNC:45708 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 RPE65  retinoid isomerohydrolase RPE65    RPE65, retinoid isomerohydrolase  Symbol and/or name change 5135510 APPROVED