FANCM (FA complementation group M) - Rat Genome Database

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Gene: FANCM (FA complementation group M) Canis lupus familiaris
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Symbol: FANCM
Name: FA complementation group M
RGD ID: 12183235
Description: ENCODES a protein that exhibits 3'-5' DNA helicase activity (inferred); ATP binding (inferred); chromatin binding (inferred); INVOLVED IN DNA duplex unwinding (inferred); DNA repair (inferred); double-strand break repair via synthesis-dependent strand annealing (inferred); ASSOCIATED WITH aplastic anemia (ortholog); azoospermia (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); FOUND IN chromatin (ortholog); FANCM-MHF complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fanconi anemia complementation group M
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1822,561,862 - 22,625,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl822,562,147 - 22,623,994 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha822,379,967 - 22,443,217 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0822,721,187 - 22,784,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl822,721,241 - 22,782,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1822,383,584 - 22,446,699 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0822,449,937 - 22,513,049 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0822,785,967 - 22,848,837 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FANCM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1822,561,862 - 22,625,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl822,562,147 - 22,623,994 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha822,379,967 - 22,443,217 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0822,721,187 - 22,784,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl822,721,241 - 22,782,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1822,383,584 - 22,446,699 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0822,449,937 - 22,513,049 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0822,785,967 - 22,848,837 (+)NCBIUU_Cfam_GSD_1.0
FANCM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381445,135,930 - 45,200,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1445,135,930 - 45,200,890 (+)EnsemblGRCh38hg38GRCh38
GRCh371445,605,133 - 45,670,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361444,674,886 - 44,739,840 (+)NCBINCBI36Build 36hg18NCBI36
Celera1425,466,389 - 25,531,345 (+)NCBICelera
Cytogenetic Map14q21.2NCBI
HuRef1425,716,007 - 25,780,814 (+)NCBIHuRef
CHM1_11445,543,284 - 45,608,236 (+)NCBICHM1_1
T2T-CHM13v2.01439,327,942 - 39,392,898 (+)NCBIT2T-CHM13v2.0
Fancm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391265,120,884 - 65,178,616 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1265,122,377 - 65,178,832 (+)EnsemblGRCm39 Ensembl
GRCm381265,074,110 - 65,131,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1265,075,603 - 65,132,058 (+)EnsemblGRCm38mm10GRCm38
MGSCv371266,176,593 - 66,233,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361265,994,211 - 66,050,663 (+)NCBIMGSCv36mm8
Celera1266,205,293 - 66,261,759 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1227.21NCBI
Fancm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8688,862,898 - 88,916,701 (+)NCBIGRCr8
mRatBN7.2683,126,903 - 83,180,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl683,127,093 - 83,180,028 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0686,823,195 - 86,877,067 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,823,684 - 86,876,633 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0696,312,237 - 96,365,616 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4686,424,156 - 86,476,902 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1686,462,951 - 86,480,559 (+)NCBI
Celera681,694,524 - 81,748,389 (+)NCBICelera
Cytogenetic Map6q24NCBI
Fancm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540916,751,658 - 16,809,352 (-)NCBIChiLan1.0ChiLan1.0
FANCM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21546,307,022 - 46,373,092 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11445,523,532 - 45,589,603 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01425,752,295 - 25,817,001 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11444,080,146 - 44,143,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1444,080,146 - 44,143,958 (+)Ensemblpanpan1.1panPan2
Fancm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864054,543,349 - 54,604,838 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365834,085,802 - 4,145,621 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FANCM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1175,334,141 - 175,400,685 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11175,333,965 - 175,402,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21195,220,132 - 195,287,229 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FANCM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12422,255,750 - 22,327,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2422,256,236 - 22,329,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666116215,894 - 286,697 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fancm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473123,340,460 - 23,392,040 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473123,342,313 - 23,391,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FANCM
654 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 2 1 4 8
Below cutoff 3 5 21 5 6 5 5 6 8 10 6

Sequence


RefSeq Acc Id: ENSCAFT00000022327   ⟹   ENSCAFP00000020735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl822,562,147 - 22,623,994 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046644   ⟹   ENSCAFP00000041513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl822,562,147 - 22,623,994 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000048988   ⟹   ENSCAFP00000038210
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl822,562,147 - 22,623,994 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003286   ⟹   ENSCAFP00845002606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl822,721,241 - 22,782,983 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003322   ⟹   ENSCAFP00845002632
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl822,721,241 - 22,782,983 (+)Ensembl
RefSeq Acc Id: XM_038483173   ⟹   XP_038339101
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1822,383,584 - 22,446,699 (+)NCBI
RefSeq Acc Id: XM_038544622   ⟹   XP_038400550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0822,785,967 - 22,848,837 (+)NCBI
RefSeq Acc Id: XM_038608748   ⟹   XP_038464676
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0822,449,937 - 22,513,049 (+)NCBI
RefSeq Acc Id: XM_038673546   ⟹   XP_038529474
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0822,721,187 - 22,784,324 (+)NCBI
RefSeq Acc Id: XM_537429   ⟹   XP_537429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1822,561,862 - 22,625,077 (+)NCBI
Dog10K_Boxer_Tasha822,379,967 - 22,443,217 (+)NCBI
Sequence:
RefSeq Acc Id: XP_537429   ⟸   XM_537429
- UniProtKB: A0A8P0NSJ1 (UniProtKB/TrEMBL),   A0A8C0R9X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000038210   ⟸   ENSCAFT00000048988
RefSeq Acc Id: ENSCAFP00000020735   ⟸   ENSCAFT00000022327
RefSeq Acc Id: ENSCAFP00000041513   ⟸   ENSCAFT00000046644
RefSeq Acc Id: XP_038339101   ⟸   XM_038483173
RefSeq Acc Id: XP_038464676   ⟸   XM_038608748
RefSeq Acc Id: XP_038529474   ⟸   XM_038673546
- UniProtKB: A0A8C0Q1I4 (UniProtKB/TrEMBL),   A0A8I3MML5 (UniProtKB/TrEMBL),   A0A8C0R9X7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400550   ⟸   XM_038544622
- UniProtKB: A0A8C0R9X7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845002606   ⟸   ENSCAFT00845003286
RefSeq Acc Id: ENSCAFP00845002632   ⟸   ENSCAFT00845003322

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014062 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000993 UniProtKB/TrEMBL
  ENSCAFG00040002237 UniProtKB/TrEMBL
  ENSCAFG00845001871 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046644.4 UniProtKB/TrEMBL
  ENSCAFT00000048988.3 UniProtKB/TrEMBL
  ENSCAFT00030001789.1 UniProtKB/TrEMBL
  ENSCAFT00040004256.1 UniProtKB/TrEMBL
  ENSCAFT00040004287.1 UniProtKB/TrEMBL
  ENSCAFT00040004301.1 UniProtKB/TrEMBL
  ENSCAFT00845003286 ENTREZGENE
  ENSCAFT00845003286.1 UniProtKB/TrEMBL
  ENSCAFT00845003322.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10130 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
  hef helicase domain UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  ERCC4_domain UniProtKB/TrEMBL
  FANCM-MHF-bd UniProtKB/TrEMBL
  FANCM/Mph1-like UniProtKB/TrEMBL
  FANCM_DEXDc UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Restrct_endonuc-II-like UniProtKB/TrEMBL
  RuvA_2-like UniProtKB/TrEMBL
  XPF_nuclease_FANCM UniProtKB/TrEMBL
KEGG Report cfa:480307 UniProtKB/TrEMBL
NCBI Gene FANCM ENTREZGENE
PANTHER FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER UniProtKB/TrEMBL
  PTHR14025:SF20 UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  ERCC4 UniProtKB/TrEMBL
  FANCM-MHF_bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  ERCC4 UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF47781 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF52980 UniProtKB/TrEMBL
UniProt A0A8C0Q1I4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R9X7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RVY5_CANLF UniProtKB/TrEMBL
  A0A8C0RW61_CANLF UniProtKB/TrEMBL
  A0A8I3MML5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RQ98_CANLF UniProtKB/TrEMBL
  A0A8P0NSJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0ST28_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40725 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-15 FANCM  FA complementation group M    Fanconi anemia complementation group M  Symbol and/or name change 5135510 APPROVED