LRPAP1 (LDL receptor related protein associated protein 1) - Rat Genome Database

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Gene: LRPAP1 (LDL receptor related protein associated protein 1) Canis lupus familiaris
Analyze
Symbol: LRPAP1
Name: LDL receptor related protein associated protein 1
RGD ID: 12179809
Description: ENCODES a protein that exhibits lipase binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN amyloid-beta clearance by transcytosis (ortholog); negative regulation of amyloid-beta clearance (ortholog); negative regulation of cell death (ortholog); PARTICIPATES IN Hedgehog signaling pathway; Reelin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); dementia (ortholog); membranous glomerulonephritis (ortholog); FOUND IN cis-Golgi network (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: alpha-2-macroglobulin receptor-associated protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,840,804 - 60,852,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,840,882 - 60,901,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,491,109 - 63,503,659 (+)NCBI
ROS_Cfam_1.0361,316,241 - 61,328,837 (+)NCBI
UMICH_Zoey_3.1360,810,231 - 60,822,660 (+)NCBI
UNSW_CanFamBas_1.0361,016,034 - 61,028,737 (+)NCBI
UU_Cfam_GSD_1.0361,371,717 - 61,384,645 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LRPAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,840,804 - 60,852,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,840,882 - 60,901,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,491,109 - 63,503,659 (+)NCBI
ROS_Cfam_1.0361,316,241 - 61,328,837 (+)NCBI
UMICH_Zoey_3.1360,810,231 - 60,822,660 (+)NCBI
UNSW_CanFamBas_1.0361,016,034 - 61,028,737 (+)NCBI
UU_Cfam_GSD_1.0361,371,717 - 61,384,645 (+)NCBI
LRPAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl43,503,612 - 3,532,446 (-)EnsemblGRCh38hg38GRCh38
GRCh3843,503,612 - 3,532,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3743,505,339 - 3,534,149 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,484,093 - 3,503,941 (-)NCBINCBI36hg18NCBI36
Build 3443,551,263 - 3,571,113NCBI
Celera43,424,737 - 3,444,504 (-)NCBI
Cytogenetic Map4p16.3NCBI
HuRef43,444,900 - 3,473,683 (-)NCBIHuRef
CHM1_143,503,272 - 3,531,989 (-)NCBICHM1_1
Lrpap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,248,834 - 35,263,043 (-)NCBIGRCm39mm39
GRCm39 Ensembl535,248,845 - 35,263,110 (-)Ensembl
GRCm38535,091,490 - 35,105,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,091,501 - 35,105,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37535,434,155 - 35,448,346 (-)NCBIGRCm37mm9NCBIm37
MGSCv36535,408,367 - 35,422,558 (-)NCBImm8
Celera532,566,121 - 32,580,312 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map518.01NCBI
Lrpap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21475,651,371 - 75,663,380 (+)NCBI
Rnor_6.0 Ensembl1480,911,270 - 80,924,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01480,911,281 - 80,923,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01481,599,969 - 81,611,978 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,292,661 - 81,304,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,295,093 - 81,308,456 (+)NCBI
Celera1474,577,874 - 74,589,883 (+)NCBICelera
Cytogenetic Map14q21NCBI
Lrpap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,195,228 - 2,208,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,195,228 - 2,208,258 (-)NCBIChiLan1.0ChiLan1.0
LRPAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.143,646,179 - 3,666,098 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,646,179 - 3,666,098 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v043,663,649 - 3,683,450 (-)NCBIMhudiblu_PPA_v0panPan3
Lrpap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,532,896 - 66,549,059 (+)NCBI
SpeTri2.0NW_00493647720,234,582 - 20,250,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRPAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,125,405 - 2,145,647 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.182,129,492 - 2,145,632 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,826,228 - 1,842,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRPAP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,206,455 - 45,225,766 (+)NCBI
ChlSab1.1 Ensembl2745,206,618 - 45,225,767 (+)Ensembl
Lrpap1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475524,436,128 - 24,447,923 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 12 8 10 6
Low 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023207   ⟹   ENSCAFP00000021550
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl360,840,882 - 60,901,258 (+)Ensembl
RefSeq Acc Id: XM_038472203   ⟹   XP_038328131
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1360,810,231 - 60,822,660 (+)NCBI
RefSeq Acc Id: XM_038533166   ⟹   XP_038389094
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0361,371,717 - 61,384,645 (+)NCBI
RefSeq Acc Id: XM_038597496   ⟹   XP_038453424
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0361,016,034 - 61,028,737 (+)NCBI
RefSeq Acc Id: XM_038661676   ⟹   XP_038517604
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0361,316,241 - 61,328,837 (+)NCBI
RefSeq Acc Id: XM_536218   ⟹   XP_536218
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1360,840,804 - 60,852,821 (+)NCBI
Dog10K_Boxer_Tasha363,491,109 - 63,503,659 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038328131 (Get FASTA)   NCBI Sequence Viewer  
  XP_038389094 (Get FASTA)   NCBI Sequence Viewer  
  XP_038453424 (Get FASTA)   NCBI Sequence Viewer  
  XP_038517604 (Get FASTA)   NCBI Sequence Viewer  
  XP_536218 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_536218   ⟸   XM_536218
- UniProtKB: F1PAG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000021550   ⟸   ENSCAFT00000023207
RefSeq Acc Id: XP_038328131   ⟸   XM_038472203
RefSeq Acc Id: XP_038453424   ⟸   XM_038597496
RefSeq Acc Id: XP_038517604   ⟸   XM_038661676
RefSeq Acc Id: XP_038389094   ⟸   XM_038533166
Promoters
RGD ID:13682795
Promoter ID:EPDNEW_C864
Type:initiation region
Name:LRPAP1_1
Description:LDL receptor related protein associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1360,840,903 - 60,840,963EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014607 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000021550 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023207 UniProtKB/TrEMBL
Gene3D-CATH 1.20.81.10 UniProtKB/TrEMBL
InterPro A2-macroglobuin_RAP UniProtKB/TrEMBL
  Alpha_2_MRAP_C UniProtKB/TrEMBL
  EFTu-like_2 UniProtKB/TrEMBL
  MG_RAP_rcpt_1 UniProtKB/TrEMBL
  RAP_D2 UniProtKB/TrEMBL
  RAP_D3 UniProtKB/TrEMBL
  RAP_sf UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/TrEMBL
  Transl_elong_EF1A/Init_IF2_C UniProtKB/TrEMBL
  Transl_elong_EFTu/EF1A_C UniProtKB/TrEMBL
NCBI Gene LRPAP1 ENTREZGENE
PANTHER PTHR16560 UniProtKB/TrEMBL
Pfam Alpha-2-MRAP_C UniProtKB/TrEMBL
  Alpha-2-MRAP_N UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/TrEMBL
  GTP_EFTU_D3 UniProtKB/TrEMBL
Superfamily-SCOP SSF47045 UniProtKB/TrEMBL
  SSF50447 UniProtKB/TrEMBL
  SSF50465 UniProtKB/TrEMBL
UniProt F1PAG7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42780 ENTREZGENE