ITGB1BP1 (integrin subunit beta 1 binding protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ITGB1BP1 (integrin subunit beta 1 binding protein 1) Canis lupus familiaris
Analyze
Symbol: ITGB1BP1
Name: integrin subunit beta 1 binding protein 1
RGD ID: 12179695
Description: ENCODES a protein that exhibits kinase binding (ortholog); protein kinase binding (ortholog); INVOLVED IN myoblast migration (ortholog); negative regulation of cell adhesion involved in substrate-bound cell migration (ortholog); negative regulation of fibroblast migration (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH bone development disease (ortholog); Craniofacial Abnormalities (ortholog); genetic disease (ortholog); FOUND IN focal adhesion (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin beta 1 binding protein 1; integrin beta-1-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,524,602 - 6,537,321 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl176,524,613 - 6,537,233 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,452,429 - 6,465,110 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,623,442 - 6,636,129 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,623,416 - 6,636,121 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,515,976 - 6,528,650 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,518,396 - 6,531,054 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,531,756 - 6,544,438 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
cell-matrix adhesion  (IEA)
cellular response to fibroblast growth factor stimulus  (IEA)
cellular response to vascular endothelial growth factor stimulus  (IEA)
integrin activation  (IEA)
integrin-mediated signaling pathway  (IEA)
myoblast migration  (ISO)
negative regulation of cell adhesion involved in substrate-bound cell migration  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of fibroblast migration  (ISO)
negative regulation of focal adhesion assembly  (IEA)
negative regulation of protein targeting to membrane  (IEA)
negative regulation of substrate adhesion-dependent cell spreading  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
protein localization to plasma membrane  (IEA)
receptor clustering  (ISO)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of integrin-mediated signaling pathway  (ISO)
tube formation  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ITGB1BP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,524,602 - 6,537,321 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl176,524,613 - 6,537,233 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,452,429 - 6,465,110 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,623,442 - 6,636,129 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,623,416 - 6,636,121 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,515,976 - 6,528,650 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,518,396 - 6,531,054 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,531,756 - 6,544,438 (-)NCBIUU_Cfam_GSD_1.0
ITGB1BP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3829,403,475 - 9,423,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl29,403,475 - 9,423,528 (-)EnsemblGRCh38hg38GRCh38
GRCh3729,543,604 - 9,563,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,463,264 - 9,481,094 (-)NCBINCBI36Build 36hg18NCBI36
Build 3429,496,414 - 9,514,233NCBI
Celera29,457,992 - 9,475,539 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef29,391,245 - 9,409,126 (-)NCBIHuRef
CHM1_129,475,472 - 9,493,078 (-)NCBICHM1_1
T2T-CHM13v2.029,428,778 - 9,448,648 (-)NCBIT2T-CHM13v2.0
Itgb1bp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,317,247 - 21,336,285 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,290,826 - 21,336,285 (-)EnsemblGRCm39 Ensembl
GRCm381221,267,246 - 21,286,292 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,240,825 - 21,286,284 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,267,420 - 21,286,284 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,275,667 - 21,292,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,516,296 - 21,532,727 (-)NCBIMGSCv36mm8
Celera1219,618,971 - 19,635,133 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
Itgb1bp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,549,994 - 46,564,735 (-)NCBIGRCr8
mRatBN7.2640,820,693 - 40,836,074 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,821,339 - 40,836,037 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,143,504 - 41,157,832 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,458,196 - 41,472,523 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,891,459 - 40,905,787 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,348,927 - 43,363,633 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,348,958 - 43,363,335 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,216,633 - 60,231,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,830,110 - 41,844,514 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,833,498 - 41,847,916 (-)NCBI
Celera640,108,431 - 40,122,817 (-)NCBICelera
Cytogenetic Map6q16NCBI
Itgb1bp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,134,135 - 5,146,449 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,134,135 - 5,146,449 (-)NCBIChiLan1.0ChiLan1.0
ITGB1BP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212117,103,099 - 117,119,941 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A117,107,072 - 117,123,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,396,553 - 9,413,408 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,559,416 - 9,576,899 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A9,556,857 - 9,577,155 (-)Ensemblpanpan1.1panPan2
Itgb1bp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,047,715 - 51,059,189 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,799,342 - 5,814,199 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,802,761 - 5,814,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB1BP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,905,810 - 126,922,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,905,779 - 126,921,961 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,174,258 - 135,295,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB1BP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,226,666 - 98,244,094 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1498,230,100 - 98,248,862 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604514,079,143 - 14,096,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb1bp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624969290,570 - 301,189 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624969290,601 - 307,152 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ITGB1BP1
83 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000039706   ⟹   ENSCAFP00000035591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl176,524,613 - 6,533,663 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060174   ⟹   ENSCAFP00000050599
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl176,525,673 - 6,537,233 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093232   ⟹   ENSCAFP00000047988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl176,524,784 - 6,537,233 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042506   ⟹   ENSCAFP00845033318
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl176,623,416 - 6,636,094 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042566   ⟹   ENSCAFP00845033372
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl176,623,580 - 6,636,121 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042626   ⟹   ENSCAFP00845033422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl176,623,585 - 6,636,094 (-)Ensembl
RefSeq Acc Id: XM_003639602   ⟹   XP_003639650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1176,524,602 - 6,537,321 (-)NCBI
Dog10K_Boxer_Tasha176,452,429 - 6,465,110 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038498213   ⟹   XP_038354141
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1176,515,976 - 6,528,650 (-)NCBI
RefSeq Acc Id: XM_038560750   ⟹   XP_038416678
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0176,531,756 - 6,544,438 (-)NCBI
RefSeq Acc Id: XM_038624780   ⟹   XP_038480708
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0176,518,396 - 6,531,054 (-)NCBI
RefSeq Acc Id: XM_038690685   ⟹   XP_038546613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0176,623,442 - 6,636,129 (-)NCBI
RefSeq Acc Id: XP_003639650   ⟸   XM_003639602
- UniProtKB: A0A8C0JG55 (UniProtKB/TrEMBL),   A0A8C0QEE3 (UniProtKB/TrEMBL),   A0A8I3S804 (UniProtKB/TrEMBL),   A0A8C0M6S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035591   ⟸   ENSCAFT00000039706
RefSeq Acc Id: ENSCAFP00000050599   ⟸   ENSCAFT00000060174
RefSeq Acc Id: ENSCAFP00000047988   ⟸   ENSCAFT00000093232
RefSeq Acc Id: XP_038354141   ⟸   XM_038498213
RefSeq Acc Id: XP_038480708   ⟸   XM_038624780
RefSeq Acc Id: XP_038546613   ⟸   XM_038690685
- UniProtKB: A0A8C0JG55 (UniProtKB/TrEMBL),   A0A8C0QEE3 (UniProtKB/TrEMBL),   A0A8I3S804 (UniProtKB/TrEMBL),   A0A8C0M6S1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416678   ⟸   XM_038560750
- UniProtKB: A0A8C0JG55 (UniProtKB/TrEMBL),   A0A8C0M6S1 (UniProtKB/TrEMBL),   A0A8C0QEE3 (UniProtKB/TrEMBL),   A0A8I3S804 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033372   ⟸   ENSCAFT00845042566
RefSeq Acc Id: ENSCAFP00845033318   ⟸   ENSCAFT00845042506
RefSeq Acc Id: ENSCAFP00845033422   ⟸   ENSCAFT00845042626
Protein Domains
PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003372 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004431 UniProtKB/TrEMBL
  ENSCAFG00040005817 UniProtKB/TrEMBL
  ENSCAFG00845024064 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039706.4 UniProtKB/TrEMBL
  ENSCAFT00000060174.2 UniProtKB/TrEMBL
  ENSCAFT00000093232.2 UniProtKB/TrEMBL
  ENSCAFT00030008155.1 UniProtKB/TrEMBL
  ENSCAFT00040010911.1 UniProtKB/TrEMBL
  ENSCAFT00040010926.1 UniProtKB/TrEMBL
  ENSCAFT00040010932.1 UniProtKB/TrEMBL
  ENSCAFT00845042506 ENTREZGENE
  ENSCAFT00845042506.1 UniProtKB/TrEMBL
  ENSCAFT00845042566.1 UniProtKB/TrEMBL
  ENSCAFT00845042626.1 UniProtKB/TrEMBL
Gene3D-CATH 6.20.360.10 UniProtKB/TrEMBL
InterPro Integrin-bd_ICAP-1 UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
KEGG Report cfa:100856378 UniProtKB/TrEMBL
NCBI Gene ITGB1BP1 ENTREZGENE
PANTHER INTEGRIN BETA-1-BINDING PROTEIN 1 UniProtKB/TrEMBL
  PTHR32055 UniProtKB/TrEMBL
Pfam ICAP-1_inte_bdg UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8C0JG55 ENTREZGENE
  A0A8C0M6S1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QEE3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QEF2_CANLF UniProtKB/TrEMBL
  A0A8C0RYN2_CANLF UniProtKB/TrEMBL
  A0A8I3PLE0_CANLF UniProtKB/TrEMBL
  A0A8I3PQM1_CANLF UniProtKB/TrEMBL
  A0A8I3S804 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T398_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42137 ENTREZGENE