GSDMA (gasdermin A) - Rat Genome Database

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Gene: GSDMA (gasdermin A) Canis lupus familiaris
Analyze
Symbol: GSDMA
Name: gasdermin A
RGD ID: 12178622
Description: ENCODES a protein that exhibits phosphatidylinositol-4,5-bisphosphate binding (inferred); phosphatidylinositol-4-phosphate binding (inferred); phosphatidylserine binding (inferred); INVOLVED IN defense response to bacterium (inferred); programmed cell death (inferred); pyroptosis (inferred); ASSOCIATED WITH genetic disease (ortholog); hypertrophic cardiomyopathy 25 (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gasdermin 1; gasdermin-A; GSDM1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,555,834 - 22,569,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,556,192 - 22,566,849 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,027,786 - 22,040,475 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,348,528 - 23,361,224 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,348,528 - 23,361,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,121,866 - 22,134,549 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,381,037 - 22,393,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,505,607 - 22,518,328 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GSDMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,555,834 - 22,569,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,556,192 - 22,566,849 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,027,786 - 22,040,475 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,348,528 - 23,361,224 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,348,528 - 23,361,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,121,866 - 22,134,549 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,381,037 - 22,393,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,505,607 - 22,518,328 (-)NCBIUU_Cfam_GSD_1.0
GSDMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,963,004 - 39,977,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,953,263 - 39,977,768 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,119,257 - 38,134,021 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,372,752 - 35,387,545 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,372,751 - 35,387,545NCBI
Celera1734,779,300 - 34,794,093 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1733,913,253 - 33,928,039 (+)NCBIHuRef
CHM1_11738,354,903 - 38,369,695 (+)NCBICHM1_1
T2T-CHM13v2.01740,826,865 - 40,841,632 (+)NCBIT2T-CHM13v2.0
Gsdma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,555,163 - 98,568,534 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,555,177 - 98,568,534 (+)EnsemblGRCm39 Ensembl
GRCm381198,664,337 - 98,677,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,664,351 - 98,677,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,525,665 - 98,539,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,480,441 - 98,493,798 (+)NCBIMGSCv36mm8
Celera11108,318,708 - 108,332,064 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.34NCBI
Gsdma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,110,590 - 84,135,804 (+)NCBIGRCr8
mRatBN7.21083,614,336 - 83,639,543 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,627,051 - 83,639,543 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,570,918 - 88,583,412 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,068,995 - 88,081,490 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,461,689 - 83,474,184 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,569,898 - 86,595,102 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,582,612 - 86,595,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,366,219 - 86,391,418 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,439,818 - 87,452,308 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1082,375,216 - 82,387,710 (+)NCBICelera
Cytogenetic Map10q31NCBI
Gsdma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,650,344 - 14,663,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,650,342 - 14,663,609 (+)NCBIChiLan1.0ChiLan1.0
GSDMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,977,393 - 24,996,438 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,872,184 - 26,887,196 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,311,932 - 17,324,004 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,531,767 - 17,543,413 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,531,767 - 17,543,413 (-)Ensemblpanpan1.1panPan2
Gsdma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,960,085 - 21,971,536 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,105,030 - 15,114,599 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,105,030 - 15,115,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSDMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,363,376 - 22,379,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,364,457 - 22,379,123 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,822,462 - 22,837,111 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSDMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,193,042 - 66,209,375 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,194,174 - 66,205,549 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,103,687 - 37,115,407 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsdma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,182,512 - 3,190,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,182,256 - 3,191,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GSDMA
186 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low
Below cutoff 5 2 14 3 6 3 8 8 9 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025816   ⟹   ENSCAFP00000023974
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,556,192 - 22,566,849 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018487   ⟹   ENSCAFP00845014426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,348,528 - 23,361,732 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018566   ⟹   ENSCAFP00845014484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,348,528 - 23,361,732 (-)Ensembl
RefSeq Acc Id: XM_005624544   ⟹   XP_005624601
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,555,834 - 22,569,141 (-)NCBI
Dog10K_Boxer_Tasha922,027,786 - 22,040,475 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038485639   ⟹   XP_038341567
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1922,121,866 - 22,134,549 (-)NCBI
RefSeq Acc Id: XM_038547406   ⟹   XP_038403334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0922,505,607 - 22,518,328 (-)NCBI
RefSeq Acc Id: XM_038611389   ⟹   XP_038467317
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0922,381,037 - 22,393,738 (-)NCBI
RefSeq Acc Id: XM_038676583   ⟹   XP_038532511
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,348,528 - 23,361,224 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005624601   ⟸   XM_005624544
- UniProtKB: A0A8C0NAQ1 (UniProtKB/TrEMBL),   A0A8I3N5U6 (UniProtKB/TrEMBL),   A0A8I3NAD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023974   ⟸   ENSCAFT00000025816
RefSeq Acc Id: XP_038341567   ⟸   XM_038485639
RefSeq Acc Id: XP_038467317   ⟸   XM_038611389
RefSeq Acc Id: XP_038532511   ⟸   XM_038676583
- UniProtKB: A0A8C0NAQ1 (UniProtKB/TrEMBL),   A0A8I3N5U6 (UniProtKB/TrEMBL),   A0A8I3NAD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403334   ⟸   XM_038547406
- UniProtKB: A0A8C0NAQ1 (UniProtKB/TrEMBL),   A0A8I3N5U6 (UniProtKB/TrEMBL),   A0A8I3NAD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014484   ⟸   ENSCAFT00845018566
RefSeq Acc Id: ENSCAFP00845014426   ⟸   ENSCAFT00845018487
Protein Domains
Gasdermin pore forming   Gasdermin PUB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016283 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013526 UniProtKB/TrEMBL
  ENSCAFG00040000943 UniProtKB/TrEMBL
  ENSCAFG00845010494 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025816.5 UniProtKB/TrEMBL
  ENSCAFT00030025014.1 UniProtKB/TrEMBL
  ENSCAFT00040001710.1 UniProtKB/TrEMBL
  ENSCAFT00845018487 ENTREZGENE
  ENSCAFT00845018487.1 UniProtKB/TrEMBL
  ENSCAFT00845018566.1 UniProtKB/TrEMBL
InterPro Gasdermin_pore UniProtKB/TrEMBL
  Gasdermin_PUB UniProtKB/TrEMBL
NCBI Gene GSDMA ENTREZGENE
PANTHER GASDERMIN-A UniProtKB/TrEMBL
  PTHR16399 UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/TrEMBL
  Gasdermin_C UniProtKB/TrEMBL
UniProt A0A8C0NAQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N5U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NAD9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54951 ENTREZGENE