DCT (dopachrome tautomerase) - Rat Genome Database

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Gene: DCT (dopachrome tautomerase) Canis lupus familiaris
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Symbol: DCT
Name: dopachrome tautomerase
RGD ID: 12177890
Description: ENCODES a protein that exhibits dopachrome isomerase activity (ortholog); INVOLVED IN cell development (ortholog); developmental pigmentation (ortholog); melanin biosynthetic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH Albinism (ortholog); Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); holoprosencephaly 5 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); L-dopachrome tautomerase; TRP-2; tyrosinase-related protein-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,271,709 - 45,305,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,271,709 - 45,305,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2245,058,426 - 45,092,104 (-)NCBI
ROS_Cfam_1.02245,702,218 - 45,736,012 (-)NCBI
UMICH_Zoey_3.12245,356,018 - 45,389,781 (-)NCBI
UNSW_CanFamBas_1.02245,396,691 - 45,430,530 (-)NCBI
UU_Cfam_GSD_1.02245,406,488 - 45,440,246 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:9745679  


Genomics

Comparative Map Data
DCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,271,709 - 45,305,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,271,709 - 45,305,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2245,058,426 - 45,092,104 (-)NCBI
ROS_Cfam_1.02245,702,218 - 45,736,012 (-)NCBI
UMICH_Zoey_3.12245,356,018 - 45,389,781 (-)NCBI
UNSW_CanFamBas_1.02245,396,691 - 45,430,530 (-)NCBI
UU_Cfam_GSD_1.02245,406,488 - 45,440,246 (-)NCBI
DCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1394,436,811 - 94,479,682 (-)EnsemblGRCh38hg38GRCh38
GRCh381394,436,811 - 94,549,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371395,089,065 - 95,201,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361393,889,836 - 93,929,924 (-)NCBINCBI36hg18NCBI36
Build 341393,889,839 - 93,929,924NCBI
Celera1375,940,079 - 75,980,144 (-)NCBI
Cytogenetic Map13q32.1NCBI
HuRef1375,688,784 - 75,728,851 (-)NCBIHuRef
CHM1_11395,061,346 - 95,101,397 (-)NCBICHM1_1
Dct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,250,202 - 118,289,658 (-)NCBIGRCm39mm39
GRCm39 Ensembl14118,250,202 - 118,289,656 (-)Ensembl
GRCm3814118,012,790 - 118,052,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,012,790 - 118,052,244 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714118,412,012 - 118,451,468 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614116,895,153 - 116,934,531 (-)NCBImm8
Celera14116,565,242 - 116,604,520 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1461.6NCBI
Dct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21595,062,006 - 95,100,863 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1595,062,003 - 95,100,836 (-)Ensembl
Rnor_6.015103,208,174 - 103,245,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,208,258 - 103,244,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015106,647,067 - 106,681,458 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415102,798,699 - 102,832,240 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1593,915,976 - 93,952,737 (-)NCBICelera
Cytogenetic Map15q24NCBI
Dct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540415,359,402 - 15,395,535 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540415,359,402 - 15,395,556 (+)NCBIChiLan1.0ChiLan1.0
DCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11394,773,794 - 94,886,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1394,773,794 - 94,816,083 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01375,590,366 - 75,730,956 (-)NCBIMhudiblu_PPA_v0panPan3
Dct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945180,841,728 - 180,877,214 (-)NCBI
SpeTri2.0NW_00493647215,074,947 - 15,110,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1163,584,866 - 63,678,314 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11163,584,865 - 63,647,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21169,660,271 - 69,730,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1373,246,161 - 73,315,574 (-)NCBI
ChlSab1.1 Ensembl373,274,621 - 73,313,905 (-)Ensembl
Vero_WHO_p1.0NW_02366604629,653,840 - 29,766,858 (-)NCBI
Dct
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248791,241,593 - 1,346,765 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system
High
Medium
Low 6 6
Below cutoff 1 9 1 6 1 6 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008571   ⟹   ENSCAFP00000007942
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2245,271,709 - 45,305,346 (-)Ensembl
RefSeq Acc Id: NM_001284466   ⟹   NP_001271395
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12245,271,709 - 45,305,272 (-)NCBI
Dog10K_Boxer_Tasha2245,058,426 - 45,092,104 (-)NCBI
ROS_Cfam_1.02245,702,218 - 45,736,012 (-)NCBI
UMICH_Zoey_3.12245,356,018 - 45,389,781 (-)NCBI
UNSW_CanFamBas_1.02245,396,691 - 45,430,530 (-)NCBI
UU_Cfam_GSD_1.02245,406,488 - 45,440,246 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001271395 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB84165 (Get FASTA)   NCBI Sequence Viewer  
  BAM73285 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001271395   ⟸   NM_001284466
- UniProtKB: L0N6C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007942   ⟸   ENSCAFT00000008571


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005323 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000007942 ENTREZGENE
Ensembl Transcript ENSCAFT00000008571 ENTREZGENE
NCBI Gene DCT ENTREZGENE
UniProt L0N6C6 ENTREZGENE
VGNC ID VGNC:39814 ENTREZGENE