BHLHE41 (basic helix-loop-helix family member e41) - Rat Genome Database

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Gene: BHLHE41 (basic helix-loop-helix family member e41) Canis lupus familiaris
Analyze
Symbol: BHLHE41
Name: basic helix-loop-helix family member e41
RGD ID: 12176859
Description: ENCODES a protein that exhibits bHLH transcription factor binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN regulation of neuronal synaptic plasticity (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH esophageal cancer (ortholog); Familial Natural Short Sleep 1 (ortholog); lung adenocarcinoma (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix domain containing, class B3; BHLHB3; class E basic helix-loop-helix protein 41; DEC2; SHARP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12721,464,302 - 21,469,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2724,913,768 - 24,918,529 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02721,659,233 - 21,663,998 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2721,659,186 - 21,663,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12721,469,068 - 21,473,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02721,491,838 - 21,496,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02725,081,155 - 25,085,938 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12909371   PMID:22301074   PMID:25403511   PMID:30032202  


Genomics

Comparative Map Data
BHLHE41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12721,464,302 - 21,469,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2724,913,768 - 24,918,529 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02721,659,233 - 21,663,998 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2721,659,186 - 21,663,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12721,469,068 - 21,473,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02721,491,838 - 21,496,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02725,081,155 - 25,085,938 (-)NCBIUU_Cfam_GSD_1.0
BHLHE41
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,120,030 - 26,125,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,120,030 - 26,125,037 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,272,963 - 26,277,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,164,226 - 26,169,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 341226,164,227 - 26,169,113NCBI
Celera1231,419,506 - 31,424,550 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1226,043,295 - 26,047,960 (-)NCBIHuRef
CHM1_11226,237,976 - 26,243,020 (-)NCBICHM1_1
T2T-CHM13v2.01225,992,585 - 25,998,690 (-)NCBIT2T-CHM13v2.0
Bhlhe41
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,803,969 - 145,811,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,803,969 - 145,811,284 (-)EnsemblGRCm39 Ensembl
GRCm386145,858,243 - 145,865,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,858,243 - 145,865,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,811,257 - 145,813,860 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,819,896 - 145,822,499 (-)NCBIMGSCv36mm8
Celera6148,934,952 - 148,937,555 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.7NCBI
Bhlhe41
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84180,565,003 - 180,569,415 (-)NCBIGRCr8
mRatBN7.24178,834,264 - 178,838,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4178,834,271 - 178,838,468 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4185,117,084 - 185,121,450 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,901,598 - 180,905,964 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04179,522,031 - 179,526,399 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04180,230,742 - 180,235,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,232,382 - 180,234,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04244,394,139 - 244,398,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4167,334,944 - 167,338,512 (-)NCBICelera
Cytogenetic Map4q44NCBI
Bhlhe41
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541321,100,021 - 21,103,358 (-)NCBIChiLan1.0ChiLan1.0
BHLHE41
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21070,697,481 - 70,702,552 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11270,693,542 - 70,698,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01260,194,758 - 60,199,344 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11262,806,113 - 62,810,773 (+)NCBIpanpan1.1PanPan1.1panPan2
Bhlhe41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494583,384,039 - 83,391,789 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365481,306,939 - 1,314,678 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHLHE41
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl547,686,404 - 47,692,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1547,687,662 - 47,692,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2551,429,074 - 51,433,848 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BHLHE41
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11125,872,139 - 25,879,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1125,874,108 - 25,876,826 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660699,196,174 - 9,200,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe41
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475213,000,525 - 13,003,079 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475213,000,238 - 13,004,777 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BHLHE41
65 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845046201   ⟹   ENSCAFP00845036278
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2721,659,186 - 21,662,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845046252   ⟹   ENSCAFP00845036319
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2721,659,233 - 21,663,998 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845046335   ⟹   ENSCAFP00845036387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2721,659,233 - 21,663,998 (+)Ensembl
RefSeq Acc Id: NM_001002973   ⟹   NP_001002973
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12721,464,302 - 21,469,119 (+)NCBI
Dog10K_Boxer_Tasha2724,913,768 - 24,918,529 (-)NCBI
ROS_Cfam_1.02721,659,233 - 21,663,998 (+)NCBI
UMICH_Zoey_3.12721,469,068 - 21,473,810 (+)NCBI
UNSW_CanFamBas_1.02721,491,838 - 21,496,575 (+)NCBI
UU_Cfam_GSD_1.02725,081,155 - 25,085,938 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001002973   ⟸   NM_001002973
- UniProtKB: Q7YQC9 (UniProtKB/TrEMBL),   A0A8C0PIK1 (UniProtKB/TrEMBL),   A0A8C0KKV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00845036387   ⟸   ENSCAFT00845046335
Ensembl Acc Id: ENSCAFP00845036319   ⟸   ENSCAFT00845046252
Ensembl Acc Id: ENSCAFP00845036278   ⟸   ENSCAFT00845046201
Protein Domains
bHLH   Orange

Promoters
RGD ID:13688156
Promoter ID:EPDNEW_C6224
Type:multiple initiation site
Name:BHLHE41_1
Description:class E basic helix-loop-helix protein 41
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12721,464,298 - 21,464,358EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000058147 UniProtKB/TrEMBL
  ENSCAFG00030026109 UniProtKB/TrEMBL
  ENSCAFG00040022130 UniProtKB/TrEMBL
  ENSCAFG00845026188 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000100836.1 UniProtKB/TrEMBL
  ENSCAFT00000109403.1 UniProtKB/TrEMBL
  ENSCAFT00030048287.1 UniProtKB/TrEMBL
  ENSCAFT00030048289.1 UniProtKB/TrEMBL
  ENSCAFT00040041084.1 UniProtKB/TrEMBL
  ENSCAFT00845046201.1 UniProtKB/TrEMBL
  ENSCAFT00845046252 ENTREZGENE
  ENSCAFT00845046252.1 UniProtKB/TrEMBL
  ENSCAFT00845046335.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HES_HEY UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
KEGG Report cfa:403457 UniProtKB/TrEMBL
NCBI Gene BHLHE41 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
  CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41 UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/TrEMBL
  SSF47459 UniProtKB/TrEMBL
UniProt A0A8C0KKV3 ENTREZGENE
  A0A8C0PIK1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PMU9_CANLF UniProtKB/TrEMBL
  A0A8I3PND5_CANLF UniProtKB/TrEMBL
  A0A8I3PNP0_CANLF UniProtKB/TrEMBL
  A0A8I3PNX8_CANLF UniProtKB/TrEMBL
  A0A8P0PKT6_CANLF UniProtKB/TrEMBL
  A0A8P0PSS9_CANLF UniProtKB/TrEMBL
  Q7YQC9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:57419 ENTREZGENE