MTHFS (methenyltetrahydrofolate synthetase) - Rat Genome Database

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Gene: MTHFS (methenyltetrahydrofolate synthetase) Canis lupus familiaris
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Symbol: MTHFS
Name: methenyltetrahydrofolate synthetase
RGD ID: 12174762
Description: ENCODES a protein that exhibits folic acid binding (ortholog); INVOLVED IN folic acid catabolic process (ortholog); glutamate metabolic process (ortholog); tetrahydrofolate metabolic process (ortholog); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; ASSOCIATED WITH Bloom syndrome (ortholog); cleft lip (ortholog); cleft palate (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; LOW QUALITY PROTEIN: 5-formyltetrahydrofolate cyclo-ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,480,935 - 57,514,836 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,139,116 - 60,173,501 (+)NCBI
ROS_Cfam_1.0357,913,790 - 57,950,014 (+)NCBI
UMICH_Zoey_3.1357,413,049 - 57,447,505 (+)NCBI
UNSW_CanFamBas_1.0357,620,059 - 57,654,466 (+)NCBI
UU_Cfam_GSD_1.0357,967,073 - 58,003,248 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MTHFS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,480,935 - 57,514,836 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,139,116 - 60,173,501 (+)NCBI
ROS_Cfam_1.0357,913,790 - 57,950,014 (+)NCBI
UMICH_Zoey_3.1357,413,049 - 57,447,505 (+)NCBI
UNSW_CanFamBas_1.0357,620,059 - 57,654,466 (+)NCBI
UU_Cfam_GSD_1.0357,967,073 - 58,003,248 (+)NCBI
MTHFS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1579,833,585 - 79,897,379 (-)EnsemblGRCh38hg38GRCh38
GRCh381579,843,547 - 79,897,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371580,135,889 - 80,189,627 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,924,373 - 77,976,425 (-)NCBINCBI36hg18NCBI36
Build 341577,924,374 - 77,976,395NCBI
Celera1557,073,628 - 57,125,676 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1556,894,007 - 56,947,724 (-)NCBIHuRef
CHM1_11580,252,880 - 80,306,583 (-)NCBICHM1_1
Mthfs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,093,243 - 89,122,278 (+)NCBIGRCm39mm39
GRCm39 Ensembl989,092,729 - 89,259,766 (+)Ensembl
GRCm38989,211,190 - 89,240,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl989,210,676 - 89,377,713 (+)EnsemblGRCm38mm10GRCm38
MGSCv37989,106,028 - 89,135,063 (+)NCBIGRCm37mm9NCBIm37
MGSCv36989,009,083 - 89,038,118 (+)NCBImm8
Celera988,839,126 - 88,843,217 (+)NCBICelera
Celera987,292,813 - 87,293,205 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
Mthfs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2889,729,498 - 89,801,998 (+)NCBI
Rnor_6.0 Ensembl896,564,877 - 96,614,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0896,564,877 - 96,614,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0896,071,796 - 96,121,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,058,605 - 94,108,277 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1894,078,059 - 94,127,729 (+)NCBI
Celera889,291,095 - 89,340,497 (+)NCBICelera
Cytogenetic Map8q31NCBI
Mthfs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955533720,255 - 756,893 (-)NCBIChiLan1.0ChiLan1.0
Mthfs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,976,748 - 120,116,548 (-)NCBI
SpeTri2.0NW_00493647137,910,856 - 37,964,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC102167410
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1748,717,518 - 48,873,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,276,934 - 54,313,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mthfs
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624941856,196 - 894,057 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 18 6 5 6 5 6 10 6
Low 3 5 4 1 1 4 6 8
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005618427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005618428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022417012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038472082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038472083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038472084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038472085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038533024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038533025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038533026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038533027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038597356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038661536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002625199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005323464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005357126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005424672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005618427   ⟹   XP_005618484
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1357,481,005 - 57,514,836 (+)NCBI
Dog10K_Boxer_Tasha360,139,136 - 60,173,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005618428   ⟹   XP_005618485
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1357,481,586 - 57,512,674 (+)NCBI
Dog10K_Boxer_Tasha360,139,807 - 60,173,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022417012   ⟹   XP_022272720
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1357,482,433 - 57,512,674 (+)NCBI
Dog10K_Boxer_Tasha360,140,642 - 60,173,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038472082   ⟹   XP_038328010
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,413,156 - 57,447,505 (+)NCBI
RefSeq Acc Id: XM_038472083   ⟹   XP_038328011
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,413,733 - 57,445,051 (+)NCBI
RefSeq Acc Id: XM_038472084   ⟹   XP_038328012
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,414,568 - 57,445,051 (+)NCBI
RefSeq Acc Id: XM_038472085   ⟹   XP_038328013
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,413,478 - 57,445,051 (+)NCBI
RefSeq Acc Id: XM_038477019   ⟹   XP_038332947
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha360,139,636 - 60,173,501 (+)NCBI
RefSeq Acc Id: XM_038533024   ⟹   XP_038388952
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0357,967,093 - 58,003,248 (+)NCBI
RefSeq Acc Id: XM_038533025   ⟹   XP_038388953
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0357,967,764 - 58,003,248 (+)NCBI
RefSeq Acc Id: XM_038533026   ⟹   XP_038388954
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0357,968,599 - 58,003,248 (+)NCBI
RefSeq Acc Id: XM_038533027   ⟹   XP_038388955
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0357,967,593 - 58,003,248 (+)NCBI
RefSeq Acc Id: XM_038597356   ⟹   XP_038453284
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0357,620,059 - 57,654,466 (+)NCBI
RefSeq Acc Id: XM_038661533   ⟹   XP_038517461
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,913,810 - 57,950,014 (+)NCBI
RefSeq Acc Id: XM_038661534   ⟹   XP_038517462
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,914,482 - 57,950,014 (+)NCBI
RefSeq Acc Id: XM_038661535   ⟹   XP_038517463
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,915,317 - 57,950,014 (+)NCBI
RefSeq Acc Id: XM_038661536   ⟹   XP_038517464
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,914,313 - 57,950,014 (+)NCBI
RefSeq Acc Id: XR_002625199
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1357,480,935 - 57,512,571 (+)NCBI
Dog10K_Boxer_Tasha360,139,116 - 60,170,944 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005323464
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1357,413,049 - 57,444,948 (+)NCBI
RefSeq Acc Id: XR_005357126
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0357,967,073 - 58,000,692 (+)NCBI
RefSeq Acc Id: XR_005424672
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0357,913,790 - 57,947,458 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005618484   ⟸   XM_005618427
- Peptide Label: isoform X3
- UniProtKB: E2RR20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005618485   ⟸   XM_005618428
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022272720   ⟸   XM_022417012
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_038328010   ⟸   XM_038472082
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038328013   ⟸   XM_038472085
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038328011   ⟸   XM_038472083
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038328012   ⟸   XM_038472084
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038453284   ⟸   XM_038597356
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038517461   ⟸   XM_038661533
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038517464   ⟸   XM_038661536
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038517462   ⟸   XM_038661534
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038517463   ⟸   XM_038661535
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038332947   ⟸   XM_038477019
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038388952   ⟸   XM_038533024
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038388955   ⟸   XM_038533027
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038388953   ⟸   XM_038533025
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038388954   ⟸   XM_038533026
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013986 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000020604 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022189 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10420 UniProtKB/TrEMBL
InterPro FTHF_cligase UniProtKB/TrEMBL
  FTHF_cligase-like_sf UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
KEGG Report cfa:610157 UniProtKB/TrEMBL
NCBI Gene MTHFS ENTREZGENE
PANTHER PTHR23407:SF1 UniProtKB/TrEMBL
Pfam 5-FTHF_cyc-lig UniProtKB/TrEMBL
PIRSF FTHF_cligase UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/TrEMBL
TIGRFAMs MTHFS_bact UniProtKB/TrEMBL
UniProt E2RR20 ENTREZGENE, UniProtKB/TrEMBL