BTG1 (BTG anti-proliferation factor 1) - Rat Genome Database

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Gene: BTG1 (BTG anti-proliferation factor 1) Canis lupus familiaris
Analyze
Symbol: BTG1
Name: BTG anti-proliferation factor 1
RGD ID: 12172701
Description: ENCODES a protein that exhibits enzyme binding (inferred); INVOLVED IN cell population proliferation (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of myoblast differentiation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); genetic disease (ortholog); juvenile rheumatoid arthritis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11532,646,520 - 32,648,222 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1532,647,472 - 32,647,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1533,100,004 - 33,102,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01533,316,253 - 33,318,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1533,316,256 - 33,318,872 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11532,596,147 - 32,598,738 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01532,659,203 - 32,661,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01532,948,922 - 32,951,509 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
BTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11532,646,520 - 32,648,222 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1532,647,472 - 32,647,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1533,100,004 - 33,102,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01533,316,253 - 33,318,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1533,316,256 - 33,318,872 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11532,596,147 - 32,598,738 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01532,659,203 - 32,661,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01532,948,922 - 32,951,509 (-)NCBIUU_Cfam_GSD_1.0
BTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381292,140,278 - 92,145,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1292,140,278 - 92,145,846 (-)EnsemblGRCh38hg38GRCh38
GRCh371292,534,054 - 92,539,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361291,061,030 - 91,063,751 (-)NCBINCBI36Build 36hg18NCBI36
Build 341291,039,370 - 91,042,088NCBI
Celera1292,205,336 - 92,210,955 (-)NCBICelera
Cytogenetic Map12q21.33NCBI
HuRef1289,601,434 - 89,607,055 (-)NCBIHuRef
CHM1_11292,499,080 - 92,504,699 (-)NCBICHM1_1
T2T-CHM13v2.01292,117,840 - 92,123,409 (-)NCBIT2T-CHM13v2.0
Btg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391096,452,863 - 96,458,675 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1096,452,868 - 96,458,671 (+)EnsemblGRCm39 Ensembl
GRCm381096,617,001 - 96,622,813 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1096,617,006 - 96,622,809 (+)EnsemblGRCm38mm10GRCm38
MGSCv371096,079,635 - 96,085,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361096,046,715 - 96,049,315 (+)NCBIMGSCv36mm8
MGSCv361096,842,504 - 96,845,104 (+)NCBIMGSCv36mm8
Celera1098,590,586 - 98,596,526 (+)NCBICelera
Cytogenetic Map10C3NCBI
cM Map1049.89NCBI
Btg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8733,228,149 - 33,230,406 (+)NCBIGRCr8
mRatBN7.2731,341,391 - 31,343,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl731,341,027 - 31,343,649 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx733,328,264 - 33,330,526 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0735,476,327 - 35,478,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0735,250,810 - 35,253,072 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0737,812,831 - 37,815,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,812,831 - 37,815,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0737,858,321 - 37,860,578 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4734,029,300 - 34,031,557 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1734,049,570 - 34,051,828 (+)NCBI
Celera728,389,620 - 28,391,877 (+)NCBICelera
Cytogenetic Map7q13NCBI
Btg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540529,206,889 - 29,209,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540529,206,889 - 29,209,407 (-)NCBIChiLan1.0ChiLan1.0
BTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210100,178,213 - 100,181,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112100,174,606 - 100,177,333 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01289,678,431 - 89,681,177 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11292,991,624 - 92,994,379 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1292,992,584 - 92,994,038 (-)Ensemblpanpan1.1panPan2
Btg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494527,438,189 - 27,445,484 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365078,789,952 - 8,797,247 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl590,815,202 - 90,817,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1590,815,194 - 90,817,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2595,088,441 - 95,091,187 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11187,553,779 - 87,556,535 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1187,554,731 - 87,556,542 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037157,620,806 - 157,624,624 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475014,526,384 - 14,533,049 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475014,526,750 - 14,529,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BTG1
10 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 20 4 6 4 6 2 8 8 10 6
Low 4 3
Below cutoff 2 2 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000009955   ⟹   ENSCAFP00000009236
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1532,647,472 - 32,647,762 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845035373   ⟹   ENSCAFP00845027691
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1533,316,256 - 33,318,872 (-)Ensembl
RefSeq Acc Id: XM_038451814   ⟹   XP_038307742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1533,100,004 - 33,102,594 (-)NCBI
RefSeq Acc Id: XM_038496249   ⟹   XP_038352177
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11532,596,147 - 32,598,738 (-)NCBI
RefSeq Acc Id: XM_038558635   ⟹   XP_038414563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01532,948,922 - 32,951,509 (-)NCBI
RefSeq Acc Id: XM_038622535   ⟹   XP_038478463
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01532,659,203 - 32,661,790 (-)NCBI
RefSeq Acc Id: XM_038688222   ⟹   XP_038544150
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01533,316,253 - 33,318,881 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000009236   ⟸   ENSCAFT00000009955
RefSeq Acc Id: XP_038352177   ⟸   XM_038496249
RefSeq Acc Id: XP_038478463   ⟸   XM_038622535
RefSeq Acc Id: XP_038544150   ⟸   XM_038688222
- UniProtKB: A0A8C0LDD1 (UniProtKB/TrEMBL),   A0A8I3P6H3 (UniProtKB/TrEMBL),   A0A8P0TR96 (UniProtKB/TrEMBL),   A0A8C0NF28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307742   ⟸   XM_038451814
- UniProtKB: A0A8C0LDD1 (UniProtKB/TrEMBL),   A0A8I3P6H3 (UniProtKB/TrEMBL),   A0A8P0TR96 (UniProtKB/TrEMBL),   A0A8C0NF28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414563   ⟸   XM_038558635
- UniProtKB: A0A8C0LDD1 (UniProtKB/TrEMBL),   A0A8C0NF28 (UniProtKB/TrEMBL),   A0A8I3P6H3 (UniProtKB/TrEMBL),   A0A8P0TR96 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845027691   ⟸   ENSCAFT00845035373
Protein Domains
Anti-proliferative protein


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006153 Ensembl
  ENSCAFG00000057784 UniProtKB/TrEMBL
  ENSCAFG00030016100 UniProtKB/TrEMBL
  ENSCAFG00845020084 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000109336.1 UniProtKB/TrEMBL
  ENSCAFT00030029658.1 UniProtKB/TrEMBL
  ENSCAFT00845035373 ENTREZGENE
  ENSCAFT00845035373.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.640.90 UniProtKB/TrEMBL
InterPro Anti_prolifrtn UniProtKB/TrEMBL
  BTG UniProtKB/TrEMBL
  BTG-like_sf UniProtKB/TrEMBL
NCBI Gene BTG1 ENTREZGENE
PANTHER PTHR22978 UniProtKB/TrEMBL
  PTHR22978:SF30 UniProtKB/TrEMBL
Pfam BTG UniProtKB/TrEMBL
PRINTS ANTIPRLFBTG1 UniProtKB/TrEMBL
PROSITE BTG_1 UniProtKB/TrEMBL
  BTG_2 UniProtKB/TrEMBL
SMART btg1 UniProtKB/TrEMBL
Superfamily-SCOP SSF160696 UniProtKB/TrEMBL
UniProt A0A8C0LDD1 ENTREZGENE
  A0A8C0NF28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P6H3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TR96 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38558 ENTREZGENE