FNDC8 (fibronectin type III domain containing 8) - Rat Genome Database

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Gene: FNDC8 (fibronectin type III domain containing 8) Canis lupus familiaris
Analyze
Symbol: FNDC8
Name: fibronectin type III domain containing 8
RGD ID: 12169932
Description: ASSOCIATED WITH genetic disease (ortholog); hereditary breast ovarian cancer syndrome (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fibronectin type III domain-containing protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,232,116 - 38,240,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,232,117 - 38,240,791 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,456,092 - 37,464,981 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,044,045 - 39,052,943 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,044,046 - 39,052,888 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,827,609 - 37,836,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,113,127 - 38,122,029 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,200,661 - 38,209,559 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FNDC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,232,116 - 38,240,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,232,117 - 38,240,791 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,456,092 - 37,464,981 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,044,045 - 39,052,943 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,044,046 - 39,052,888 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,827,609 - 37,836,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,113,127 - 38,122,029 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,200,661 - 38,209,559 (-)NCBIUU_Cfam_GSD_1.0
FNDC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,121,615 - 35,130,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,121,615 - 35,130,732 (+)EnsemblGRCh38hg38GRCh38
GRCh371733,448,634 - 33,457,751 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,472,744 - 30,481,864 (+)NCBINCBI36Build 36hg18NCBI36
Celera1730,358,824 - 30,367,943 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,633,318 - 29,642,432 (+)NCBIHuRef
CHM1_11733,512,993 - 33,522,110 (+)NCBICHM1_1
T2T-CHM13v2.01736,069,529 - 36,078,645 (+)NCBIT2T-CHM13v2.0
Fndc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,971 - 82,791,563 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,782,950 - 82,791,627 (+)EnsemblGRCm39 Ensembl
GRCm381182,892,145 - 82,900,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,892,124 - 82,900,801 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,705,647 - 82,714,239 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,708,319 - 82,716,996 (+)NCBIMGSCv36mm8
Celera1192,511,195 - 92,519,852 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
Fndc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,323,500 - 68,331,638 (+)NCBIGRCr8
mRatBN7.21067,825,952 - 67,834,090 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,825,952 - 67,834,090 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,445,992 - 72,454,130 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,951,373 - 71,959,511 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,415,477 - 67,423,603 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,242,852 - 70,250,990 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,242,874 - 70,250,934 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,874,015 - 69,882,153 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,109,016 - 71,117,154 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,122,706 - 71,129,721 (+)NCBI
Celera1066,770,188 - 66,778,326 (+)NCBICelera
Cytogenetic Map10q26NCBI
Fndc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554819,812,156 - 9,819,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554819,812,402 - 9,820,070 (+)NCBIChiLan1.0ChiLan1.0
FNDC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21929,334,255 - 29,346,016 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11731,215,227 - 31,226,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,655,487 - 21,665,633 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,947,380 - 21,956,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,947,380 - 21,956,499 (-)Ensemblpanpan1.1panPan2
Fndc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,232,976 - 37,240,130 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538111,241 - 117,961 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538110,569 - 117,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FNDC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,045,094 - 40,052,597 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,045,721 - 40,052,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,556,921 - 41,563,844 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FNDC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,624,441 - 28,633,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,624,735 - 28,633,537 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660751,353,489 - 1,363,002 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fndc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,989,359 - 2,996,183 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248752,989,290 - 2,996,406 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FNDC8
84 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 1 15 5 6 1 11 5 2
Below cutoff 4 5 7 6 1 6 5 1 5 4

Sequence


RefSeq Acc Id: ENSCAFT00000029057   ⟹   ENSCAFP00000027020
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl938,232,117 - 38,240,791 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018486   ⟹   ENSCAFP00845014425
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl939,044,046 - 39,052,888 (-)Ensembl
RefSeq Acc Id: XM_038486289   ⟹   XP_038342217
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1937,827,609 - 37,836,517 (-)NCBI
RefSeq Acc Id: XM_038548109   ⟹   XP_038404037
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0938,200,661 - 38,209,559 (-)NCBI
RefSeq Acc Id: XM_038612081   ⟹   XP_038468009
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0938,113,127 - 38,122,029 (-)NCBI
RefSeq Acc Id: XM_038677327   ⟹   XP_038533255
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0939,044,045 - 39,052,943 (-)NCBI
RefSeq Acc Id: XM_537727   ⟹   XP_537727
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1938,232,116 - 38,240,791 (-)NCBI
Dog10K_Boxer_Tasha937,456,092 - 37,464,981 (-)NCBI
Sequence:
RefSeq Acc Id: XP_537727   ⟸   XM_537727
- UniProtKB: A0A8C0NRW2 (UniProtKB/TrEMBL),   A0A8I3NF90 (UniProtKB/TrEMBL),   A0A8C0KPF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027020   ⟸   ENSCAFT00000029057
RefSeq Acc Id: XP_038342217   ⟸   XM_038486289
RefSeq Acc Id: XP_038468009   ⟸   XM_038612081
RefSeq Acc Id: XP_038533255   ⟸   XM_038677327
- UniProtKB: A0A8C0NRW2 (UniProtKB/TrEMBL),   A0A8I3NF90 (UniProtKB/TrEMBL),   A0A8C0KPF8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404037   ⟸   XM_038548109
- UniProtKB: A0A8C0KPF8 (UniProtKB/TrEMBL),   A0A8C0NRW2 (UniProtKB/TrEMBL),   A0A8I3NF90 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014425   ⟸   ENSCAFT00845018486
Protein Domains
Fibronectin type-III

Promoters
RGD ID:13684648
Promoter ID:EPDNEW_C2717
Type:single initiation site
Name:FNDC8_1
Description:fibronectin type III domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1938,240,788 - 38,240,848EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018291 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018946 UniProtKB/TrEMBL
  ENSCAFG00040010292 UniProtKB/TrEMBL
  ENSCAFG00845010495 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029057.5 UniProtKB/TrEMBL
  ENSCAFT00030034842.1 UniProtKB/TrEMBL
  ENSCAFT00040019058.1 UniProtKB/TrEMBL
  ENSCAFT00845018486 ENTREZGENE
  ENSCAFT00845018486.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report cfa:480607 UniProtKB/TrEMBL
NCBI Gene FNDC8 ENTREZGENE
PANTHER FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
  FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt A0A8C0KPF8 ENTREZGENE
  A0A8C0NRW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NF90 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40933 ENTREZGENE