DSG2 (desmoglein 2) - Rat Genome Database

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Gene: DSG2 (desmoglein 2) Canis lupus familiaris
Analyze
Symbol: DSG2
Name: desmoglein 2
RGD ID: 12169148
Description: ENCODES a protein that exhibits calcium ion binding (inferred); cell adhesion molecule binding (inferred); INVOLVED IN maternal process involved in female pregnancy (ortholog); response to progesterone (ortholog); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); arrhythmogenic right ventricular dysplasia 10 (ortholog); FOUND IN apical plasma membrane (ortholog); lateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: desmoglein-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,981,918 - 58,030,197 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,982,825 - 58,077,926 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,419,009 - 57,467,267 (-)NCBI
ROS_Cfam_1.0757,967,094 - 58,015,339 (-)NCBI
ROS_Cfam_1.0 Ensembl757,967,084 - 58,015,390 (-)Ensembl
UMICH_Zoey_3.1757,643,638 - 57,691,881 (-)NCBI
UNSW_CanFamBas_1.0757,669,703 - 57,717,915 (-)NCBI
UU_Cfam_GSD_1.0757,958,817 - 58,007,069 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30404858  


Genomics

Comparative Map Data
DSG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,981,918 - 58,030,197 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,982,825 - 58,077,926 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,419,009 - 57,467,267 (-)NCBI
ROS_Cfam_1.0757,967,094 - 58,015,339 (-)NCBI
ROS_Cfam_1.0 Ensembl757,967,084 - 58,015,390 (-)Ensembl
UMICH_Zoey_3.1757,643,638 - 57,691,881 (-)NCBI
UNSW_CanFamBas_1.0757,669,703 - 57,717,915 (-)NCBI
UU_Cfam_GSD_1.0757,958,817 - 58,007,069 (-)NCBI
DSG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1831,498,177 - 31,549,008 (+)EnsemblGRCh38hg38GRCh38
GRCh381831,498,177 - 31,549,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371829,078,140 - 29,128,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,332,170 - 27,380,754 (+)NCBINCBI36hg18NCBI36
Build 341827,332,202 - 27,380,855NCBI
Celera1825,885,149 - 25,935,936 (+)NCBI
Cytogenetic Map18q12.1NCBI
HuRef1825,934,972 - 25,985,760 (+)NCBIHuRef
CHM1_11829,005,330 - 29,056,126 (+)NCBICHM1_1
Dsg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,691,131 - 20,737,583 (+)NCBIGRCm39mm39
GRCm39 Ensembl1820,691,131 - 20,737,578 (+)Ensembl
GRCm381820,558,074 - 20,604,526 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,558,074 - 20,604,521 (+)EnsemblGRCm38mm10GRCm38
MGSCv371820,716,617 - 20,763,027 (+)NCBIGRCm37mm9NCBIm37
MGSCv361820,664,999 - 20,713,857 (+)NCBImm8
MGSCv361820,701,117 - 20,745,819 (+)NCBImm8
Celera1821,057,703 - 21,106,454 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.42NCBI
Dsg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21811,846,207 - 11,904,630 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1811,846,183 - 11,904,156 (+)Ensembl
Rnor_6.01815,579,322 - 15,637,720 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,579,315 - 15,637,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,353,348 - 15,411,825 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,306,321 - 12,366,719 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11812,366,920 - 12,391,365 (+)NCBI
Celera1811,860,565 - 11,912,367 (+)NCBICelera
Cytogenetic Map18p12NCBI
Dsg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540218,826,400 - 18,876,188 (+)NCBIChiLan1.0ChiLan1.0
DSG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11828,313,240 - 28,363,781 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,313,223 - 28,363,786 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01824,716,181 - 24,766,837 (+)NCBIMhudiblu_PPA_v0panPan3
Dsg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,674,706 - 53,721,731 (-)NCBI
SpeTri2.0NW_0049366821,676,301 - 1,725,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,400,252 - 115,452,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16115,400,223 - 115,453,763 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,027,813 - 108,079,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,174,539 - 49,227,519 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,174,409 - 49,227,347 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605023,824,149 - 23,877,098 (-)NCBIVero_WHO_p1.0
Dsg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247701,315,021 - 1,363,472 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 1 13 6 6 10
Low 2 4 9 6 6 6 4 6 8 6
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845018828   ⟹   ENSCAFP00845014701
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl757,967,084 - 58,015,390 (-)Ensembl
RefSeq Acc Id: XM_005622932   ⟹   XP_005622989
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1757,981,918 - 58,030,197 (-)NCBI
Dog10K_Boxer_Tasha757,419,009 - 57,467,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038482174   ⟹   XP_038338102
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1757,643,638 - 57,691,881 (-)NCBI
RefSeq Acc Id: XM_038543606   ⟹   XP_038399534
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0757,958,817 - 58,007,069 (-)NCBI
RefSeq Acc Id: XM_038607729   ⟹   XP_038463657
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0757,669,703 - 57,717,915 (-)NCBI
RefSeq Acc Id: XM_038672409   ⟹   XP_038528337
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0757,967,094 - 58,015,339 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005622989   ⟸   XM_005622932
- UniProtKB: F1PGX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038338102   ⟸   XM_038482174
RefSeq Acc Id: XP_038463657   ⟸   XM_038607729
RefSeq Acc Id: XP_038528337   ⟸   XM_038672409
RefSeq Acc Id: XP_038399534   ⟸   XM_038543606
RefSeq Acc Id: ENSCAFP00845014701   ⟸   ENSCAFT00845018828
Protein Domains
Cadherin

Promoters
RGD ID:13684067
Promoter ID:EPDNEW_C2136
Type:initiation region
Name:DSG2_1
Description:desmoglein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1758,030,207 - 58,030,267EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 57984631 57984632 C T snv Chinese indigenous dogs (LJ1), Chinese indigenous dogs (LJ10), Chinese indigenous dogs (LJ2), Tibetan Mastiff (TM3), Chinese indigenous dogs (YJ6), Chinese indigenous dogs (LJ4), Tibetan Mastiff (TM1)
7 58001330 58001331 C T snv Chinese indigenous dogs (LJ2)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018051 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845010678 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000026677 UniProtKB/TrEMBL
  ENSCAFP00000026681 UniProtKB/TrEMBL
  ENSCAFP00000054677 UniProtKB/TrEMBL
  ENSCAFP00000055141 UniProtKB/TrEMBL
  ENSCAFP00000056147 UniProtKB/TrEMBL
  ENSCAFP00000064529 UniProtKB/TrEMBL
  ENSCAFP00000065154 UniProtKB/TrEMBL
  ENSCAFP00845014701 ENTREZGENE
Ensembl Transcript ENSCAFT00000028681 UniProtKB/TrEMBL
  ENSCAFT00000028685 UniProtKB/TrEMBL
  ENSCAFT00000064942 UniProtKB/TrEMBL
  ENSCAFT00000066125 UniProtKB/TrEMBL
  ENSCAFT00000070793 UniProtKB/TrEMBL
  ENSCAFT00000081695 UniProtKB/TrEMBL
  ENSCAFT00000087866 UniProtKB/TrEMBL
  ENSCAFT00845018828 ENTREZGENE
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Catenin-bd_sf UniProtKB/TrEMBL
  Desmoglein UniProtKB/TrEMBL
  Desmosomal_cadherin UniProtKB/TrEMBL
KEGG Report cfa:490500 UniProtKB/TrEMBL
NCBI Gene DSG2 ENTREZGENE
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
PRINTS CADHERIN UniProtKB/TrEMBL
  DESMOCADHERN UniProtKB/TrEMBL
  DESMOGLEIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
UniProt A0A5F4CJT1_CANLF UniProtKB/TrEMBL
  A0A5F4CLE4_CANLF UniProtKB/TrEMBL
  A0A5F4CTN6_CANLF UniProtKB/TrEMBL
  A0A5F4DCR0_CANLF UniProtKB/TrEMBL
  A0A5F4DEJ2_CANLF UniProtKB/TrEMBL
  F1PGX1_CANLF UniProtKB/TrEMBL
  F1PGX2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40106 ENTREZGENE