ZP4 (zona pellucida glycoprotein 4) - Rat Genome Database

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Gene: ZP4 (zona pellucida glycoprotein 4) Canis lupus familiaris
Analyze
Symbol: ZP4
Name: zona pellucida glycoprotein 4
RGD ID: 12162056
Description: ENCODES a protein that exhibits acrosin binding (inferred); identical protein binding (inferred); INVOLVED IN acrosomal vesicle exocytosis (inferred); negative regulation of binding of sperm to zona pellucida (inferred); positive regulation of acrosome reaction (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); Hereditary Leiomyomatosis and Renal Cell Cancer (ortholog); parathyroid carcinoma (ortholog); FOUND IN egg coat (inferred); extracellular region (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TAC4; tachykinin 4; zona pellicida protein B; zona pellucida sperm-binding protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.142,324,657 - 2,332,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl42,324,226 - 2,331,470 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha42,372,257 - 2,380,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.042,343,415 - 2,351,490 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl42,343,307 - 2,350,533 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.142,339,106 - 2,347,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.042,475,022 - 2,483,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.042,696,097 - 2,704,236 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:15115719   PMID:30032202  


Genomics

Comparative Map Data
ZP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.142,324,657 - 2,332,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl42,324,226 - 2,331,470 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha42,372,257 - 2,380,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.042,343,415 - 2,351,490 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl42,343,307 - 2,350,533 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.142,339,106 - 2,347,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.042,475,022 - 2,483,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.042,696,097 - 2,704,236 (+)NCBIUU_Cfam_GSD_1.0
ZP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381237,882,404 - 237,890,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1237,877,864 - 237,890,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371238,045,704 - 238,054,222 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361236,112,333 - 236,120,558 (-)NCBINCBI36Build 36hg18NCBI36
Build 341234,371,750 - 234,379,976NCBI
Celera1211,290,655 - 211,303,716 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1208,497,545 - 208,510,618 (-)NCBIHuRef
CHM1_11239,313,463 - 239,326,514 (-)NCBICHM1_1
T2T-CHM13v2.01237,293,715 - 237,302,152 (-)NCBIT2T-CHM13v2.0
Zp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81763,697,147 - 63,703,700 (-)NCBIGRCr8
mRatBN7.21759,005,649 - 59,012,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1759,005,649 - 59,012,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1762,200,994 - 62,207,550 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01766,204,050 - 66,210,606 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01760,358,390 - 60,364,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01765,497,359 - 65,503,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,497,359 - 65,503,912 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01767,248,685 - 67,255,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41769,576,957 - 69,583,510 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11769,587,789 - 69,594,343 (-)NCBI
Celera1761,538,443 - 61,544,996 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
Zp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554922,599,579 - 2,606,837 (+)NCBIChiLan1.0ChiLan1.0
ZP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,270,421 - 11,278,931 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,487,205 - 11,495,738 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01213,435,888 - 213,444,439 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11218,433,473 - 218,442,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1218,428,967 - 218,442,383 (-)Ensemblpanpan1.1panPan2
Zp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934439,205,217 - 39,211,353 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648415,370,443 - 15,376,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1453,577,135 - 53,584,546 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11453,577,138 - 53,584,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21457,496,103 - 57,503,521 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12575,002,053 - 75,010,764 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2575,002,344 - 75,010,323 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605577,101,795 - 77,109,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477512,902,697 - 12,910,149 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477512,903,145 - 12,910,048 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZP4
84 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000015935   ⟹   ENSCAFP00000014741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl42,324,226 - 2,331,470 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845004088   ⟹   ENSCAFP00845003272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl42,343,307 - 2,350,533 (+)Ensembl
RefSeq Acc Id: XM_038472801   ⟹   XP_038328729
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.142,339,106 - 2,347,238 (+)NCBI
RefSeq Acc Id: XM_038487243   ⟹   XP_038343171
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha42,372,257 - 2,380,393 (+)NCBI
RefSeq Acc Id: XM_038533813   ⟹   XP_038389741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.042,696,097 - 2,704,236 (+)NCBI
RefSeq Acc Id: XM_038598134   ⟹   XP_038454062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.042,475,022 - 2,483,157 (+)NCBI
RefSeq Acc Id: XM_038662439   ⟹   XP_038518367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.042,343,415 - 2,351,490 (+)NCBI
Ensembl Acc Id: ENSCAFP00000014741   ⟸   ENSCAFT00000015935
RefSeq Acc Id: XP_038328729   ⟸   XM_038472801
RefSeq Acc Id: XP_038454062   ⟸   XM_038598134
RefSeq Acc Id: XP_038518367   ⟸   XM_038662439
- UniProtKB: A0A8C0MWQ1 (UniProtKB/TrEMBL),   A0A8I3MSR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038343171   ⟸   XM_038487243
- UniProtKB: A0A8C0MWQ1 (UniProtKB/TrEMBL),   A0A8I3MSR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389741   ⟸   XM_038533813
- UniProtKB: A0A8C0MWQ1 (UniProtKB/TrEMBL),   A0A8I3MSR2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845003272   ⟸   ENSCAFT00845004088
Protein Domains
P-type   ZP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010014 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011161 UniProtKB/TrEMBL
  ENSCAFG00040000400 UniProtKB/TrEMBL
  ENSCAFG00845002311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015935.5 UniProtKB/TrEMBL
  ENSCAFT00000104689.1 UniProtKB/TrEMBL
  ENSCAFT00030020637.1 UniProtKB/TrEMBL
  ENSCAFT00030020731.1 UniProtKB/TrEMBL
  ENSCAFT00040000676.1 UniProtKB/TrEMBL
  ENSCAFT00040000694.1 UniProtKB/TrEMBL
  ENSCAFT00845004088 ENTREZGENE
  ENSCAFT00845004088.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/TrEMBL
  4.10.110.10 UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/TrEMBL
InterPro P_trefoil_CS UniProtKB/TrEMBL
  P_trefoil_dom UniProtKB/TrEMBL
  P_trefoil_dom_sf UniProtKB/TrEMBL
  Zona_Pellucida_Domain_gp UniProtKB/TrEMBL
  ZP-C UniProtKB/TrEMBL
  ZP1/4_Ig-like UniProtKB/TrEMBL
  ZP_chr UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/TrEMBL
NCBI Gene ZP4 ENTREZGENE
PANTHER ZONA PELLUCIDA SPERM-BINDING PROTEIN UniProtKB/TrEMBL
  ZONA PELLUCIDA SPERM-BINDING PROTEIN 4 UniProtKB/TrEMBL
Pfam Trefoil UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/TrEMBL
  ZP1_ZP4_Ig-like UniProtKB/TrEMBL
PRINTS ZPELLUCIDA UniProtKB/TrEMBL
PROSITE P_TREFOIL_1 UniProtKB/TrEMBL
  P_TREFOIL_2 UniProtKB/TrEMBL
  ZP_1 UniProtKB/TrEMBL
  ZP_2 UniProtKB/TrEMBL
SMART SM00018 UniProtKB/TrEMBL
  SM00241 UniProtKB/TrEMBL
Superfamily-SCOP SSF57492 UniProtKB/TrEMBL
UniProt A0A8C0MWQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PKR2_CANLF UniProtKB/TrEMBL
  A0A8I3MSR2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0PI06 UniProtKB/TrEMBL
VGNC ID VGNC:48843 ENTREZGENE