PLEKHO1 (pleckstrin homology domain containing O1) - Rat Genome Database

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Gene: PLEKHO1 (pleckstrin homology domain containing O1) Canis lupus familiaris
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Symbol: PLEKHO1
Name: pleckstrin homology domain containing O1
RGD ID: 12158912
Description: INVOLVED IN lamellipodium morphogenesis (ortholog); myoblast fusion (ortholog); myoblast migration (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); dyschromatosis symmetrica hereditaria (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN muscle cell projection membrane (ortholog); ruffle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family O member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,402,758 - 59,411,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,402,834 - 59,411,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,849,824 - 58,858,981 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,398,910 - 60,408,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,398,979 - 60,408,250 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,248,504 - 59,257,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,332,396 - 59,341,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,059,457 - 60,068,599 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
PLEKHO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,402,758 - 59,411,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,402,834 - 59,411,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,849,824 - 58,858,981 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,398,910 - 60,408,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,398,979 - 60,408,250 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,248,504 - 59,257,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,332,396 - 59,341,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,059,457 - 60,068,599 (+)NCBIUU_Cfam_GSD_1.0
PLEKHO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,149,646 - 150,160,065 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,149,183 - 150,164,720 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,121,836 - 150,132,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,388,794 - 148,398,449 (+)NCBINCBI36Build 36hg18NCBI36
Celera1123,237,889 - 123,247,544 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,502,507 - 121,511,229 (+)NCBIHuRef
CHM1_11151,518,106 - 151,527,756 (+)NCBICHM1_1
T2T-CHM13v2.01149,274,323 - 149,284,749 (+)NCBIT2T-CHM13v2.0
Plekho1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,896,121 - 95,903,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,895,741 - 95,903,313 (-)EnsemblGRCm39 Ensembl
GRCm38395,988,809 - 95,999,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,988,429 - 95,996,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,792,751 - 95,799,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,074,233 - 96,081,244 (-)NCBIMGSCv36mm8
Celera397,422,723 - 97,429,850 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
Plekho1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,544,487 - 183,552,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,544,499 - 183,552,785 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,208,081 - 191,216,052 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02189,012,540 - 189,020,482 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02183,840,633 - 183,848,604 (-)NCBIRnor_WKY
Rnor_6.02198,112,104 - 198,120,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,112,076 - 198,120,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,601,880 - 217,609,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,787,503 - 190,796,057 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,750,270 - 190,758,811 (-)NCBI
Celera2176,073,021 - 176,080,794 (-)NCBICelera
Cytogenetic Map2q34NCBI
Plekho1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413603,128 - 616,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955413603,011 - 606,487 (-)NCBIChiLan1.0ChiLan1.0
PLEKHO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,147,114 - 129,157,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,146,459 - 129,157,401 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01125,494,740 - 125,504,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Plekho1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,409,723 - 21,416,853 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936580440,111 - 448,651 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,923,996 - 98,934,189 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,924,115 - 98,934,610 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,197,951 - 108,208,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,137,552 - 13,148,013 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekho1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,889,560 - 17,901,213 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,889,528 - 17,898,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLEKHO1
138 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 5 1 6 1 6 6 8 5 5
Low 17 5 5 6 6 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018653   ⟹   ENSCAFP00000017280
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1759,402,834 - 59,411,788 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022447   ⟹   ENSCAFP00845017633
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1760,398,979 - 60,408,250 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022463   ⟹   ENSCAFP00845017641
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1760,398,979 - 60,408,250 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022513   ⟹   ENSCAFP00845017677
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1760,398,979 - 60,408,250 (+)Ensembl
RefSeq Acc Id: XM_038423028   ⟹   XP_038278956
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01760,398,910 - 60,408,051 (+)NCBI
RefSeq Acc Id: XM_038499521   ⟹   XP_038355449
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11759,248,504 - 59,257,633 (+)NCBI
RefSeq Acc Id: XM_038562094   ⟹   XP_038418022
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01760,059,457 - 60,068,599 (+)NCBI
RefSeq Acc Id: XM_038626189   ⟹   XP_038482117
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01759,332,396 - 59,341,732 (+)NCBI
RefSeq Acc Id: XM_844754   ⟹   XP_849847
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11759,402,758 - 59,411,906 (+)NCBI
Dog10K_Boxer_Tasha1758,849,824 - 58,858,981 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038278956 (Get FASTA)   NCBI Sequence Viewer  
  XP_038355449 (Get FASTA)   NCBI Sequence Viewer  
  XP_038418022 (Get FASTA)   NCBI Sequence Viewer  
  XP_038482117 (Get FASTA)   NCBI Sequence Viewer  
  XP_849847 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_849847   ⟸   XM_844754
- UniProtKB: A0A8C0L5P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017280   ⟸   ENSCAFT00000018653
RefSeq Acc Id: XP_038355449   ⟸   XM_038499521
RefSeq Acc Id: XP_038482117   ⟸   XM_038626189
RefSeq Acc Id: XP_038278956   ⟸   XM_038423028
- UniProtKB: A0A8C0L5P9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418022   ⟸   XM_038562094
RefSeq Acc Id: ENSCAFP00845017677   ⟸   ENSCAFT00845022513
RefSeq Acc Id: ENSCAFP00845017641   ⟸   ENSCAFT00845022463
RefSeq Acc Id: ENSCAFP00845017633   ⟸   ENSCAFT00845022447
Protein Domains
PH

Promoters
RGD ID:13686382
Promoter ID:EPDNEW_C4450
Type:initiation region
Name:PLEKHO1_1
Description:pleckstrin homology domain containing O1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11759,403,190 - 59,403,250EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011742 Ensembl
  ENSCAFG00845012601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845017633 ENTREZGENE
  ENSCAFP00845017633.1 UniProtKB/TrEMBL
  ENSCAFP00845017641.1 UniProtKB/TrEMBL
  ENSCAFP00845017677.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845022447 ENTREZGENE
  ENSCAFT00845022447.1 UniProtKB/TrEMBL
  ENSCAFT00845022463.1 UniProtKB/TrEMBL
  ENSCAFT00845022513.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro CKIP-1 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PKHO1/2 UniProtKB/TrEMBL
NCBI Gene PLEKHO1 ENTREZGENE
PANTHER PTHR15871 UniProtKB/TrEMBL
  PTHR15871:SF1 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
UniProt A0A8C0L5P9 ENTREZGENE
  A0A8I3NHF6_CANLF UniProtKB/TrEMBL
  A0A8I3NMI5_CANLF UniProtKB/TrEMBL
  A0A8I3NN72_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44687 ENTREZGENE