MFAP3 (microfibril associated protein 3) - Rat Genome Database

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Gene: MFAP3 (microfibril associated protein 3) Canis lupus familiaris
Analyze
Symbol: MFAP3
Name: microfibril associated protein 3
RGD ID: 12156929
Description: ENCODES a protein that exhibits MHC class II protein binding (inferred); protein tyrosine kinase binding (inferred); INVOLVED IN interleukin-15-mediated signaling pathway (inferred); positive regulation of ERK1 and ERK2 cascade (inferred); T cell activation (inferred); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred); membrane raft (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: microfibril-associated glycoprotein 3; microfibrillar associated protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1455,609,857 - 55,629,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl455,613,386 - 55,617,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha455,501,150 - 55,520,614 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0456,044,615 - 56,064,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl456,044,615 - 56,063,984 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1455,874,460 - 55,893,737 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0455,973,521 - 55,992,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0456,476,065 - 56,495,499 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MFAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1455,609,857 - 55,629,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl455,613,386 - 55,617,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha455,501,150 - 55,520,614 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0456,044,615 - 56,064,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl456,044,615 - 56,063,984 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1455,874,460 - 55,893,737 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0455,973,521 - 55,992,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0456,476,065 - 56,495,499 (-)NCBIUU_Cfam_GSD_1.0
MFAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385154,038,967 - 154,057,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5154,038,959 - 154,220,478 (+)EnsemblGRCh38hg38GRCh38
GRCh375153,418,527 - 153,437,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365153,398,752 - 153,414,786 (+)NCBINCBI36Build 36hg18NCBI36
Build 345153,398,751 - 153,414,785NCBI
Celera5149,494,051 - 149,512,547 (+)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5148,559,459 - 148,577,958 (+)NCBIHuRef
CHM1_15152,851,126 - 152,869,621 (+)NCBICHM1_1
T2T-CHM13v2.05154,572,102 - 154,590,586 (+)NCBIT2T-CHM13v2.0
Mfap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391157,409,478 - 57,424,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1157,409,490 - 57,424,641 (+)EnsemblGRCm39 Ensembl
GRCm381157,518,652 - 57,533,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1157,518,664 - 57,533,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv371157,332,167 - 57,347,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361157,334,860 - 57,350,012 (+)NCBIMGSCv36mm8
Celera1162,270,306 - 62,285,753 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1135.27NCBI
Mfap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,197,292 - 42,213,011 (+)NCBIGRCr8
mRatBN7.21041,696,788 - 41,711,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1041,696,771 - 41,710,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1046,362,430 - 46,374,966 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01045,852,654 - 45,865,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01041,356,282 - 41,368,818 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01042,933,077 - 42,945,591 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1042,933,077 - 42,945,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01042,738,203 - 42,750,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41043,106,313 - 43,118,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11043,119,935 - 43,132,423 (+)NCBI
Celera1040,994,612 - 41,007,128 (+)NCBICelera
Cytogenetic Map10q22NCBI
Mfap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554088,443,880 - 8,452,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554088,434,641 - 8,455,835 (+)NCBIChiLan1.0ChiLan1.0
MFAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24149,245,583 - 149,264,073 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15147,385,128 - 147,403,618 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05149,440,427 - 149,458,929 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15155,438,413 - 155,456,890 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5155,438,476 - 155,456,890 (+)Ensemblpanpan1.1panPan2
Mfap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213110,255,074 - 110,274,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365158,707,578 - 8,712,544 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365158,704,468 - 8,723,542 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1669,099,975 - 69,121,447 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11669,038,666 - 69,121,553 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21674,906,619 - 75,040,130 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MFAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12356,506,677 - 56,514,570 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2356,506,240 - 56,514,899 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603421,149,108 - 21,168,011 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473335,102,700 - 35,107,980 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473335,100,215 - 35,119,928 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MFAP3
166 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 7 5
Low 5 5 16 6 6 6 6 6 5 8 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000045985   ⟹   ENSCAFP00000039100
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl455,613,386 - 55,617,446 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008965   ⟹   ENSCAFP00845007067
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl456,044,615 - 56,063,984 (-)Ensembl
RefSeq Acc Id: XM_022417777   ⟹   XP_022273485
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1455,609,857 - 55,623,003 (-)NCBI
Dog10K_Boxer_Tasha455,501,150 - 55,514,270 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038473869   ⟹   XP_038329797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1455,874,460 - 55,893,737 (-)NCBI
RefSeq Acc Id: XM_038473870   ⟹   XP_038329798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1455,874,460 - 55,887,413 (-)NCBI
RefSeq Acc Id: XM_038534959   ⟹   XP_038390887
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0456,476,065 - 56,495,499 (-)NCBI
RefSeq Acc Id: XM_038534960   ⟹   XP_038390888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0456,476,065 - 56,489,186 (-)NCBI
RefSeq Acc Id: XM_038599259   ⟹   XP_038455187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0455,973,521 - 55,992,876 (-)NCBI
RefSeq Acc Id: XM_038599260   ⟹   XP_038455188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0455,973,521 - 55,986,624 (-)NCBI
RefSeq Acc Id: XM_038663565   ⟹   XP_038519493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0456,044,615 - 56,064,091 (-)NCBI
RefSeq Acc Id: XM_038663566   ⟹   XP_038519494
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0456,044,615 - 56,057,735 (-)NCBI
RefSeq Acc Id: XM_546284   ⟹   XP_546284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1455,609,857 - 55,629,303 (-)NCBI
Dog10K_Boxer_Tasha455,501,150 - 55,520,614 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_546284   ⟸   XM_546284
- UniProtKB: A0A8C0Q959 (UniProtKB/TrEMBL),   A0A8I3MU20 (UniProtKB/TrEMBL),   A0A8C0LJ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022273485   ⟸   XM_022417777
- UniProtKB: A0A8C0Q959 (UniProtKB/TrEMBL),   A0A8I3MU20 (UniProtKB/TrEMBL),   A0A8C0LJ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000039100   ⟸   ENSCAFT00000045985
RefSeq Acc Id: XP_038329797   ⟸   XM_038473869
RefSeq Acc Id: XP_038329798   ⟸   XM_038473870
RefSeq Acc Id: XP_038455187   ⟸   XM_038599259
RefSeq Acc Id: XP_038455188   ⟸   XM_038599260
RefSeq Acc Id: XP_038519493   ⟸   XM_038663565
- UniProtKB: A0A8C0Q959 (UniProtKB/TrEMBL),   A0A8I3MU20 (UniProtKB/TrEMBL),   A0A8C0LJ80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519494   ⟸   XM_038663566
- UniProtKB: A0A8C0Q959 (UniProtKB/TrEMBL),   A0A8I3MU20 (UniProtKB/TrEMBL),   A0A8C0LJ80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390887   ⟸   XM_038534959
- UniProtKB: A0A8C0LJ80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390888   ⟸   XM_038534960
- UniProtKB: A0A8C0LJ80 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007067   ⟸   ENSCAFT00845008965
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030060 Ensembl
  ENSCAFG00000051352 UniProtKB/TrEMBL
  ENSCAFG00030007785 UniProtKB/TrEMBL
  ENSCAFG00040006710 UniProtKB/TrEMBL
  ENSCAFG00845005006 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000108563.1 UniProtKB/TrEMBL
  ENSCAFT00030014258.1 UniProtKB/TrEMBL
  ENSCAFT00040012482.1 UniProtKB/TrEMBL
  ENSCAFT00845008965 ENTREZGENE
  ENSCAFT00845008965.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
NCBI Gene MFAP3 ENTREZGENE
PANTHER MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 UniProtKB/TrEMBL
  T-CELL SURFACE GLYCOPROTEIN CD4 UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8C0LJ80 ENTREZGENE
  A0A8C0Q959 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MU20 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43188 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 MFAP3  microfibril associated protein 3    microfibrillar associated protein 3  Symbol and/or name change 5135510 APPROVED