PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) - Rat Genome Database

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Gene: PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) Canis lupus familiaris
Analyze
Symbol: PAPSS2
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
RGD ID: 12156412
Description: ENCODES a protein that exhibits adenylylsulfate kinase activity (inferred); ATP binding (inferred); nucleotidyltransferase activity (inferred); INVOLVED IN blood coagulation (ortholog); bone development (ortholog); hormone metabolic process (ortholog); PARTICIPATES IN sulfite oxidase deficiency pathway; ASSOCIATED WITH brachyolmia (ortholog); genetic disease (ortholog); juvenile polyposis syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,725,205 - 37,745,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,725,616 - 37,743,928 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,579,442 - 37,627,983 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02639,227,070 - 39,275,831 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12637,134,164 - 37,182,464 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02636,715,608 - 36,764,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02637,955,064 - 38,003,810 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PAPSS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,725,205 - 37,745,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,725,616 - 37,743,928 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,579,442 - 37,627,983 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02639,227,070 - 39,275,831 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12637,134,164 - 37,182,464 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02636,715,608 - 36,764,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02637,955,064 - 38,003,810 (+)NCBIUU_Cfam_GSD_1.0
PAPSS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,659,878 - 87,747,705 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,659,613 - 87,747,705 (+)EnsemblGRCh38hg38GRCh38
GRCh371089,419,635 - 89,507,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361089,409,456 - 89,497,442 (+)NCBINCBI36Build 36hg18NCBI36
Build 341089,409,607 - 89,496,142NCBI
Celera1083,166,000 - 83,253,966 (+)NCBICelera
Cytogenetic Map10q23.2-q23.31NCBI
HuRef1083,054,540 - 83,142,617 (+)NCBIHuRef
CHM1_11089,701,783 - 89,789,765 (+)NCBICHM1_1
T2T-CHM13v2.01088,543,727 - 88,631,613 (+)NCBIT2T-CHM13v2.0
Papss2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,573,072 - 32,644,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1932,573,190 - 32,644,587 (+)EnsemblGRCm39 Ensembl
GRCm381932,595,669 - 32,667,187 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,595,790 - 32,667,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,694,495 - 32,741,677 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361932,686,002 - 32,733,184 (+)NCBIMGSCv36mm8
Celera1933,402,870 - 33,450,031 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1927.46NCBI
Papss2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,867,597 - 239,952,614 (+)NCBIGRCr8
mRatBN7.21230,454,314 - 230,539,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1230,454,426 - 230,539,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1238,827,264 - 238,914,193 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,756,967 - 245,843,895 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01238,595,075 - 238,682,007 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,145,264 - 251,230,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,145,253 - 251,230,715 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01258,376,054 - 258,461,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,592,414 - 236,677,379 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,796,239 - 236,839,791 (+)NCBI
Celera1227,570,258 - 227,654,408 (+)NCBICelera
Cytogenetic Map1q52NCBI
Papss2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,187,952 - 5,258,955 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554255,186,232 - 5,259,080 (-)NCBIChiLan1.0ChiLan1.0
PAPSS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,675,589 - 99,764,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,682,336 - 99,770,207 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01084,383,936 - 84,471,745 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11087,890,631 - 87,977,839 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1087,890,631 - 87,977,839 (+)Ensemblpanpan1.1panPan2
Papss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721377,276,657 - 77,356,538 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367351,436,153 - 1,516,378 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367351,437,108 - 1,516,382 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAPSS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1499,685,578 - 99,808,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11499,718,299 - 99,816,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214108,701,055 - 108,789,588 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAPSS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1981,102,477 - 81,191,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl981,102,520 - 81,190,230 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604841,763,494 - 41,853,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Papss2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479113,789,584 - 13,866,543 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479113,789,539 - 13,866,551 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PAPSS2
626 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 5 6 6 6 5 1
Low 3 6 1 5 8 5 5
Below cutoff 2 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022410352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038576044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038576045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000035245   ⟹   ENSCAFP00000030482
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2637,725,616 - 37,743,928 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000082662   ⟹   ENSCAFP00000047187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2637,725,616 - 37,743,928 (+)Ensembl
RefSeq Acc Id: XM_038437682   ⟹   XP_038293610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02639,227,070 - 39,275,831 (+)NCBI
RefSeq Acc Id: XM_038437683   ⟹   XP_038293611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02639,227,070 - 39,275,831 (+)NCBI
RefSeq Acc Id: XM_038459239   ⟹   XP_038315167
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2637,579,442 - 37,627,983 (+)NCBI
RefSeq Acc Id: XM_038459240   ⟹   XP_038315168
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2637,579,442 - 37,627,983 (+)NCBI
RefSeq Acc Id: XM_038512554   ⟹   XP_038368482
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12637,134,164 - 37,182,464 (+)NCBI
RefSeq Acc Id: XM_038512555   ⟹   XP_038368483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12637,134,164 - 37,182,464 (+)NCBI
RefSeq Acc Id: XM_038576044   ⟹   XP_038431972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02637,955,064 - 38,003,810 (+)NCBI
RefSeq Acc Id: XM_038576045   ⟹   XP_038431973
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02637,955,064 - 38,003,810 (+)NCBI
RefSeq Acc Id: XM_038640257   ⟹   XP_038496185
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02636,715,608 - 36,764,348 (+)NCBI
RefSeq Acc Id: XM_038640258   ⟹   XP_038496186
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02636,715,608 - 36,764,348 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000030482   ⟸   ENSCAFT00000035245
RefSeq Acc Id: ENSCAFP00000047187   ⟸   ENSCAFT00000082662
RefSeq Acc Id: XP_038368482   ⟸   XM_038512554
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038368483   ⟸   XM_038512555
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038496185   ⟸   XM_038640257
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038496186   ⟸   XM_038640258
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038293610   ⟸   XM_038437682
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Z5P4 (UniProtKB/TrEMBL),   A0A8I3Q7N2 (UniProtKB/TrEMBL),   A0A8I3SC67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038293611   ⟸   XM_038437683
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TPU6 (UniProtKB/TrEMBL),   A0A8C0LP25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315167   ⟸   XM_038459239
- Peptide Label: isoform X1
- UniProtKB: A0A8P0T059 (UniProtKB/TrEMBL),   A0A8P0SPC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315168   ⟸   XM_038459240
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LP25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431972   ⟸   XM_038576044
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SPC9 (UniProtKB/TrEMBL),   A0A8P0T059 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431973   ⟸   XM_038576045
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LP25 (UniProtKB/TrEMBL)
Protein Domains
ATP-sulfurylase PUA-like   Sulphate adenylyltransferase catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015654 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040023649 UniProtKB/TrEMBL
  ENSCAFG00845029238 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000035245.4 UniProtKB/TrEMBL
  ENSCAFT00000082662.2 UniProtKB/TrEMBL
  ENSCAFT00000106658.1 UniProtKB/TrEMBL
  ENSCAFT00040044150.1 UniProtKB/TrEMBL
  ENSCAFT00040044192.1 UniProtKB/TrEMBL
  ENSCAFT00845051738 ENTREZGENE
  ENSCAFT00845051738.1 UniProtKB/TrEMBL
  ENSCAFT00845051766.1 UniProtKB/TrEMBL
  ENSCAFT00845051819 ENTREZGENE
  ENSCAFT00845051819.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/TrEMBL
  Sulfate adenylyltransferase UniProtKB/TrEMBL
InterPro APS_kinase UniProtKB/TrEMBL
  ATP-Sase_PUA-like_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PUA-like_sf UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  Sulfurylase_cat_dom UniProtKB/TrEMBL
  Sulphate_adenylyltransferase UniProtKB/TrEMBL
NCBI Gene PAPSS2 ENTREZGENE
PANTHER BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE UniProtKB/TrEMBL
  BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2 UniProtKB/TrEMBL
Pfam APS_kinase UniProtKB/TrEMBL
  ATP-sulfurylase UniProtKB/TrEMBL
  PUA_2 UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF88697 UniProtKB/TrEMBL
UniProt A0A8C0LP25 ENTREZGENE
  A0A8C0TPU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z5P4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q616_CANLF UniProtKB/TrEMBL
  A0A8I3Q7N2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3SC67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PHP5_CANLF UniProtKB/TrEMBL
  A0A8P0SPC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T059 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49936 ENTREZGENE