ADARB2 (adenosine deaminase RNA specific B2 (inactive)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ADARB2 (adenosine deaminase RNA specific B2 (inactive)) Canis lupus familiaris
Analyze
Symbol: ADARB2
Name: adenosine deaminase RNA specific B2 (inactive)
RGD ID: 12154270
Description: ENCODES a protein that exhibits adenosine deaminase activity (inferred); double-stranded RNA adenosine deaminase activity (inferred); double-stranded RNA binding (inferred); INVOLVED IN adenosine to inosine editing (inferred); RNA processing (inferred); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); Parkinson's disease (ortholog); FOUND IN cytoplasm (inferred); nucleolus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenosine deaminase, RNA specific B2 (inactive); adenosine deaminase, RNA-specific, B2 (RED2 homolog rat); double-stranded RNA-specific editase B2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,510,081 - 33,848,968 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,510,961 - 33,847,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha230,547,773 - 30,882,564 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0233,898,956 - 34,231,649 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl234,142,371 - 34,233,124 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1230,980,140 - 31,314,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0231,821,371 - 32,155,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0232,567,978 - 32,901,861 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleolus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADARB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,510,081 - 33,848,968 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,510,961 - 33,847,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha230,547,773 - 30,882,564 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0233,898,956 - 34,231,649 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl234,142,371 - 34,233,124 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1230,980,140 - 31,314,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0231,821,371 - 32,155,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0232,567,978 - 32,901,861 (+)NCBIUU_Cfam_GSD_1.0
ADARB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38101,177,313 - 1,737,525 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl101,177,313 - 1,737,525 (-)EnsemblGRCh38hg38GRCh38
GRCh37101,223,253 - 1,779,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36101,218,073 - 1,769,670 (-)NCBINCBI36Build 36hg18NCBI36
Build 34101,218,072 - 1,769,670NCBI
Celera101,177,236 - 1,724,446 (-)NCBICelera
Cytogenetic Map10p15.3NCBI
HuRef101,161,831 - 1,714,807 (-)NCBIHuRef
CHM1_1101,223,357 - 1,778,901 (-)NCBICHM1_1
T2T-CHM13v2.0101,174,042 - 1,734,916 (-)NCBIT2T-CHM13v2.0
Adarb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,252,475 - 8,818,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,252,902 - 8,818,783 (+)EnsemblGRCm39 Ensembl
GRCm38138,202,526 - 8,768,762 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,202,866 - 8,768,747 (+)EnsemblGRCm38mm10GRCm38
MGSCv37138,202,155 - 8,759,554 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36138,202,174 - 8,758,251 (+)NCBIMGSCv36mm8
Celera138,141,995 - 8,704,669 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.48NCBI
Adarb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81766,660,586 - 67,211,104 (-)NCBIGRCr8
mRatBN7.21761,750,437 - 62,300,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1761,756,067 - 62,300,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1765,276,950 - 65,815,159 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01769,105,757 - 69,643,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01763,127,154 - 63,665,371 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01758,098,979 - 58,653,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1758,104,559 - 58,301,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01759,899,851 - 60,449,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41772,680,982 - 73,238,156 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11772,691,814 - 73,248,989 (-)NCBI
Celera1754,538,865 - 55,080,965 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Adarb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542129,830,905 - 30,022,685 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542129,705,289 - 30,028,013 (+)NCBIChiLan1.0ChiLan1.0
ADARB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2813,710,717 - 14,279,208 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11013,716,029 - 14,284,531 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0101,219,560 - 1,786,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1101,266,559 - 1,805,825 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl101,268,327 - 1,449,173 (-)Ensemblpanpan1.1panPan2
Adarb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934436,235,715 - 36,715,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648412,401,502 - 12,875,689 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648412,400,903 - 12,876,572 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADARB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1068,013,449 - 68,467,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11068,013,531 - 68,468,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21075,135,379 - 75,302,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADARB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.191,136,461 - 1,644,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl91,137,037 - 1,301,657 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660516,194,489 - 6,714,274 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adarb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247759,090,545 - 9,643,355 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247759,089,839 - 9,646,985 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADARB2
7234 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 5 4
Below cutoff 1 5 1 5 6 3 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008891   ⟹   ENSCAFP00000008248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,510,961 - 33,847,412 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000045133   ⟹   ENSCAFP00000040274
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl233,757,493 - 33,847,412 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000208   ⟹   ENSCAFP00845000152
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl234,142,371 - 34,233,124 (+)Ensembl
RefSeq Acc Id: XM_038457586   ⟹   XP_038313514
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha230,547,773 - 30,882,564 (+)NCBI
RefSeq Acc Id: XM_038469457   ⟹   XP_038325385
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1230,980,140 - 31,314,975 (+)NCBI
RefSeq Acc Id: XM_038530219   ⟹   XP_038386147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0232,567,978 - 32,901,861 (+)NCBI
RefSeq Acc Id: XM_038594466   ⟹   XP_038450394
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0231,821,371 - 32,155,620 (+)NCBI
RefSeq Acc Id: XM_038658511   ⟹   XP_038514439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0233,898,956 - 34,231,649 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000040274   ⟸   ENSCAFT00000045133
RefSeq Acc Id: ENSCAFP00000008248   ⟸   ENSCAFT00000008891
RefSeq Acc Id: XP_038325385   ⟸   XM_038469457
RefSeq Acc Id: XP_038450394   ⟸   XM_038594466
RefSeq Acc Id: XP_038514439   ⟸   XM_038658511
- UniProtKB: A0A8C0PWY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313514   ⟸   XM_038457586
- UniProtKB: A0A8C0PWY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386147   ⟸   XM_038530219
- UniProtKB: A0A8C0PWY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000152   ⟸   ENSCAFT00845000208
Protein Domains
A to I editase   DRBM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029140 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002676 UniProtKB/TrEMBL
  ENSCAFG00040002146 UniProtKB/TrEMBL
  ENSCAFG00845000130 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045133.3 UniProtKB/TrEMBL
  ENSCAFT00030004990.1 UniProtKB/TrEMBL
  ENSCAFT00040004089.1 UniProtKB/TrEMBL
  ENSCAFT00845000208 ENTREZGENE
  ENSCAFT00845000208.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.160.20 UniProtKB/TrEMBL
InterPro A_deamin UniProtKB/TrEMBL
  ADAR3_DSRM_1 UniProtKB/TrEMBL
  dsRBD_dom UniProtKB/TrEMBL
NCBI Gene ADARB2 ENTREZGENE
PANTHER DOUBLE-STRANDED RNA-SPECIFIC EDITASE B2 UniProtKB/TrEMBL
  EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN UniProtKB/TrEMBL
Pfam A_deamin UniProtKB/TrEMBL
  dsrm UniProtKB/TrEMBL
PROSITE A_DEAMIN_EDITASE UniProtKB/TrEMBL
  DS_RBD UniProtKB/TrEMBL
SMART ADEAMc UniProtKB/TrEMBL
  DSRM UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
UniProt A0A8C0PWY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3M9Y0_CANLF UniProtKB/TrEMBL
  A0A8P0NRH2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:111329 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 ADARB2  adenosine deaminase RNA specific B2 (inactive)    adenosine deaminase, RNA specific B2 (inactive)  Symbol and/or name change 5135510 APPROVED