DUSP26 (dual specificity phosphatase 26) - Rat Genome Database

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Gene: DUSP26 (dual specificity phosphatase 26) Canis lupus familiaris
Analyze
Symbol: DUSP26
Name: dual specificity phosphatase 26
RGD ID: 12153418
Description: ENCODES a protein that exhibits MAP kinase phosphatase activity (inferred); p53 binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN negative regulation of ERK1 and ERK2 cascade (inferred); negative regulation of MAPK cascade (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred); Golgi apparatus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity phosphatase 26 (putative); dual specificity protein phosphatase 26
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,115,317 - 31,122,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,115,475 - 31,132,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1631,638,685 - 31,647,937 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01633,140,928 - 33,146,814 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1633,141,000 - 33,147,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11631,237,257 - 31,246,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01631,816,290 - 31,822,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01631,854,968 - 31,864,230 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DUSP26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,115,317 - 31,122,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,115,475 - 31,132,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1631,638,685 - 31,647,937 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01633,140,928 - 33,146,814 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1633,141,000 - 33,147,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11631,237,257 - 31,246,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01631,816,290 - 31,822,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01631,854,968 - 31,864,230 (+)NCBIUU_Cfam_GSD_1.0
DUSP26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38833,591,330 - 33,600,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl833,591,330 - 33,600,023 (-)EnsemblGRCh38hg38GRCh38
GRCh37833,448,848 - 33,457,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36833,568,393 - 33,576,981 (-)NCBINCBI36Build 36hg18NCBI36
Celera832,398,523 - 32,407,113 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef831,980,747 - 31,988,923 (-)NCBIHuRef
CHM1_1833,650,334 - 33,658,924 (-)NCBICHM1_1
T2T-CHM13v2.0833,862,584 - 33,871,277 (-)NCBIT2T-CHM13v2.0
Dusp26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39831,579,555 - 31,587,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl831,579,499 - 31,587,075 (+)EnsemblGRCm39 Ensembl
GRCm38831,089,527 - 31,097,046 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,089,471 - 31,097,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv37832,200,134 - 32,207,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36832,555,597 - 32,562,982 (+)NCBIMGSCv36mm8
Celera832,614,701 - 32,622,121 (+)NCBICelera
Cytogenetic Map8A3NCBI
cM Map817.93NCBI
Dusp26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81667,744,830 - 67,752,673 (-)NCBIGRCr8
mRatBN7.21661,041,784 - 61,049,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1661,041,792 - 61,049,051 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1666,357,195 - 66,364,502 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01669,771,709 - 69,779,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01664,998,081 - 65,005,413 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01664,798,782 - 64,806,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1664,798,778 - 64,806,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01664,455,731 - 64,463,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41664,952,300 - 64,959,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11664,952,379 - 64,959,679 (-)NCBI
Celera1659,046,361 - 59,053,665 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
Dusp26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554639,712,954 - 9,718,959 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554639,712,943 - 9,718,959 (-)NCBIChiLan1.0ChiLan1.0
DUSP26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2752,166,122 - 52,174,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1827,881,863 - 27,890,613 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0832,906,182 - 32,915,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1830,091,084 - 30,100,699 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl830,091,092 - 30,100,699 (-)Ensemblpanpan1.1panPan2
Dusp26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,103,079 - 54,109,849 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936766363,029 - 370,281 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936766363,172 - 370,234 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21559,480,305 - 59,486,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1831,667,984 - 31,679,040 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl831,666,691 - 31,679,058 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605210,369,786 - 10,378,220 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478010,368,975 - 10,375,215 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478010,368,988 - 10,376,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUSP26
120 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 14 6 12 10 2
Low 1 8 6 6 6 6 8 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046440   ⟹   ENSCAFP00000038741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1631,115,475 - 31,132,033 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845025866   ⟹   ENSCAFP00845020383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1633,141,000 - 33,147,846 (+)Ensembl
RefSeq Acc Id: XM_038452555   ⟹   XP_038308483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1631,638,685 - 31,647,937 (+)NCBI
RefSeq Acc Id: XM_038497659   ⟹   XP_038353587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11631,237,257 - 31,246,487 (+)NCBI
RefSeq Acc Id: XM_038560135   ⟹   XP_038416063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01631,854,968 - 31,864,230 (+)NCBI
RefSeq Acc Id: XM_038624179   ⟹   XP_038480107
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01631,816,290 - 31,822,141 (+)NCBI
RefSeq Acc Id: XM_038689934   ⟹   XP_038545862
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01633,140,928 - 33,146,814 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000038741   ⟸   ENSCAFT00000046440
RefSeq Acc Id: XP_038353587   ⟸   XM_038497659
RefSeq Acc Id: XP_038480107   ⟸   XM_038624179
RefSeq Acc Id: XP_038545862   ⟸   XM_038689934
- UniProtKB: A0A8C0PLF4 (UniProtKB/TrEMBL),   A0A8I3NTS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308483   ⟸   XM_038452555
- UniProtKB: A0A8C0PLF4 (UniProtKB/TrEMBL),   A0A8I3NTS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416063   ⟸   XM_038560135
- UniProtKB: A0A8C0PLF4 (UniProtKB/TrEMBL),   A0A8I3NTS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020383   ⟸   ENSCAFT00845025866
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029801 Ensembl
  ENSCAFG00000057614 UniProtKB/TrEMBL
  ENSCAFG00030024829 UniProtKB/TrEMBL
  ENSCAFG00040014324 UniProtKB/TrEMBL
  ENSCAFG00845014461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000094419.1 UniProtKB/TrEMBL
  ENSCAFT00000098191.1 UniProtKB/TrEMBL
  ENSCAFT00000105249.1 UniProtKB/TrEMBL
  ENSCAFT00030045734.1 UniProtKB/TrEMBL
  ENSCAFT00040026408.1 UniProtKB/TrEMBL
  ENSCAFT00040026482.1 UniProtKB/TrEMBL
  ENSCAFT00845025866 ENTREZGENE
  ENSCAFT00845025866.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Atypical_DUSP_subfamA UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
NCBI Gene DUSP26 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 26 UniProtKB/TrEMBL
  PTHR45682 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
PRINTS ADSPHPHTASE UniProtKB/TrEMBL
  ADSPHPHTASEA UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8C0PLF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YYC4_CANLF UniProtKB/TrEMBL
  A0A8I3NTS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PI46_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0TRC6 UniProtKB/TrEMBL
VGNC ID VGNC:51798 ENTREZGENE