CD244 (CD244 molecule) - Rat Genome Database

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Gene: CD244 (CD244 molecule) Canis lupus familiaris
Analyze
Symbol: CD244
Name: CD244 molecule
RGD ID: 12152539
Description: ENCODES a protein that exhibits MHC class I protein binding (inferred); INVOLVED IN myeloid dendritic cell activation (ortholog); positive regulation of CD8-positive, alpha-beta T cell proliferation (ortholog); positive regulation of natural killer cell proliferation (ortholog); ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: natural killer cell receptor 2B4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,495,649 - 21,522,656 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,495,720 - 21,517,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,569,007 - 21,595,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,612,462 - 21,640,210 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,612,683 - 21,640,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,500,470 - 21,527,135 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,914,237 - 21,940,917 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,324,134 - 22,350,862 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CD244
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,495,649 - 21,522,656 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,495,720 - 21,517,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,569,007 - 21,595,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,612,462 - 21,640,210 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,612,683 - 21,640,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,500,470 - 21,527,135 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,914,237 - 21,940,917 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,324,134 - 22,350,862 (+)NCBIUU_Cfam_GSD_1.0
CD244
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,830,160 - 160,862,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,830,160 - 160,862,887 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,799,950 - 160,832,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,066,574 - 159,099,269 (-)NCBINCBI36Build 36hg18NCBI36
Build 341157,613,023 - 157,645,718NCBI
Celera1133,868,617 - 133,900,871 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,156,082 - 132,188,997 (-)NCBIHuRef
CHM1_11162,195,333 - 162,228,071 (-)NCBICHM1_1
T2T-CHM13v2.01159,967,199 - 159,999,910 (-)NCBIT2T-CHM13v2.0
Cd244a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,386,761 - 171,412,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,386,761 - 171,437,314 (+)EnsemblGRCm39 Ensembl
GRCm381171,558,718 - 171,585,316 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,559,193 - 171,609,746 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,489,324 - 173,515,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,395,874 - 173,420,233 (+)NCBIMGSCv36mm8
MGSCv361172,839,241 - 172,863,626 (+)NCBIMGSCv36mm8
Celera1174,415,055 - 174,442,954 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.52NCBI
Cd244l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,547,250 - 86,569,026 (+)NCBIGRCr8
mRatBN7.21384,018,887 - 84,036,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,020,095 - 84,036,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,525,877 - 86,541,884 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,924,115 - 87,939,720 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,124,263 - 85,139,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,959,091 - 89,995,993 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,975,267 - 89,995,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,596,434 - 94,618,284 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,513,413 - 87,531,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,702,296 - 87,720,095 (+)NCBI
Celera1383,694,456 - 83,704,305 (+)NCBICelera
Cytogenetic Map13q24NCBI
Cd244
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,534,064 - 12,559,434 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,532,937 - 12,559,859 (-)NCBIChiLan1.0ChiLan1.0
CD244
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,983,026 - 89,018,767 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,723,340 - 88,759,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,186,906 - 136,219,669 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,109,626 - 140,142,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,110,808 - 140,123,065 (-)Ensemblpanpan1.1panPan2
Cd244
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,937,563 - 6,965,410 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936903146,108 - 162,410 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD244
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,668,239 - 89,700,972 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,668,221 - 89,700,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,546,648 - 97,579,398 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD244
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,103,226 - 3,138,322 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660382,143,657 - 2,178,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd244
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794447,584 - 472,778 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794447,572 - 472,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CD244
399 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 5 11 5 1 5 6 10 8 7 5
Below cutoff 5 11 1 1 6 2 3 1

Sequence


RefSeq Acc Id: ENSCAFT00000020086   ⟹   ENSCAFP00000018628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3821,495,720 - 21,517,043 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845053467   ⟹   ENSCAFP00845042012
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,612,683 - 21,640,215 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845053472   ⟹   ENSCAFP00845042015
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,612,683 - 21,640,215 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845053490   ⟹   ENSCAFP00845042025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,612,683 - 21,638,984 (+)Ensembl
RefSeq Acc Id: XM_038448660   ⟹   XP_038304588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03821,612,462 - 21,640,210 (+)NCBI
RefSeq Acc Id: XM_038464050   ⟹   XP_038319978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3821,569,007 - 21,595,662 (+)NCBI
RefSeq Acc Id: XM_038522546   ⟹   XP_038378474
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13821,500,470 - 21,527,135 (+)NCBI
RefSeq Acc Id: XM_038586326   ⟹   XP_038442254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03822,324,134 - 22,350,862 (+)NCBI
RefSeq Acc Id: XM_038650746   ⟹   XP_038506674
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03821,914,237 - 21,940,917 (+)NCBI
RefSeq Acc Id: ENSCAFP00000018628   ⟸   ENSCAFT00000020086
RefSeq Acc Id: XP_038378474   ⟸   XM_038522546
RefSeq Acc Id: XP_038506674   ⟸   XM_038650746
RefSeq Acc Id: XP_038304588   ⟸   XM_038448660
- UniProtKB: A0A8C0RMQ2 (UniProtKB/TrEMBL),   A0A8I3QX83 (UniProtKB/TrEMBL),   A0A8C0NU59 (UniProtKB/TrEMBL),   A0A8I3QAX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319978   ⟸   XM_038464050
- UniProtKB: A0A8C0SN87 (UniProtKB/TrEMBL),   A0A8P0PS48 (UniProtKB/TrEMBL),   A0A8P0NEJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038442254   ⟸   XM_038586326
- UniProtKB: A0A8C0NU59 (UniProtKB/TrEMBL),   A0A8C0RMQ2 (UniProtKB/TrEMBL),   A0A8I3QAX8 (UniProtKB/TrEMBL),   A0A8I3QX83 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845042012   ⟸   ENSCAFT00845053467
RefSeq Acc Id: ENSCAFP00845042025   ⟸   ENSCAFT00845053490
RefSeq Acc Id: ENSCAFP00845042015   ⟸   ENSCAFT00845053472
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012647 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017900 UniProtKB/TrEMBL
  ENSCAFG00040014937 UniProtKB/TrEMBL
  ENSCAFG00845030153 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020086.5 UniProtKB/TrEMBL
  ENSCAFT00000106907.1 UniProtKB/TrEMBL
  ENSCAFT00000108649.1 UniProtKB/TrEMBL
  ENSCAFT00030033009.1 UniProtKB/TrEMBL
  ENSCAFT00030033071.1 UniProtKB/TrEMBL
  ENSCAFT00030033134.1 UniProtKB/TrEMBL
  ENSCAFT00040027512.1 UniProtKB/TrEMBL
  ENSCAFT00845053467 ENTREZGENE
  ENSCAFT00845053467.1 UniProtKB/TrEMBL
  ENSCAFT00845053472.1 UniProtKB/TrEMBL
  ENSCAFT00845053490.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  NK_rcpt_2B4_Ig_dom UniProtKB/TrEMBL
NCBI Gene CD244 ENTREZGENE
PANTHER PTHR12080:SF56 UniProtKB/TrEMBL
  SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  Receptor_2B4 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8C0NU59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0P2X4_CANLF UniProtKB/TrEMBL
  A0A8C0RMQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SN87 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q8Q4_CANLF UniProtKB/TrEMBL
  A0A8I3QAX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QX83 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NEJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PS48 ENTREZGENE
  A0A8P0TII5_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0PS48 UniProtKB/TrEMBL
VGNC ID VGNC:53117 ENTREZGENE