MC5R (melanocortin 5 receptor) - Rat Genome Database

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Gene: MC5R (melanocortin 5 receptor) Canis lupus familiaris
Analyze
Symbol: MC5R
Name: melanocortin 5 receptor
RGD ID: 12151256
Description: ENCODES a protein that exhibits hormone binding (ortholog); melanocortin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); regulation of metabolic process (inferred); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); chromosome 18p deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: melanocortin receptor 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,429,331 - 24,433,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,410,285 - 25,414,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,326,030 - 24,331,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,328,811 - 24,329,788 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,381,249 - 24,385,125 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,267,632 - 24,271,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,538,879 - 24,544,347 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MC5R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,429,331 - 24,433,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,410,285 - 25,414,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,326,030 - 24,331,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,328,811 - 24,329,788 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,381,249 - 24,385,125 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,267,632 - 24,271,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,538,879 - 24,544,347 (-)NCBIUU_Cfam_GSD_1.0
MC5R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381813,824,149 - 13,827,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1813,824,149 - 13,827,323 (+)EnsemblGRCh38hg38GRCh38
GRCh371813,824,148 - 13,827,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361813,815,765 - 13,816,742 (+)NCBINCBI36Build 36hg18NCBI36
Build 341813,815,764 - 13,816,742NCBI
Celera1813,706,729 - 13,708,047 (+)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1813,778,780 - 13,780,099 (+)NCBIHuRef
CHM1_11813,824,630 - 13,825,948 (+)NCBICHM1_1
T2T-CHM13v2.01813,986,528 - 13,989,701 (+)NCBIT2T-CHM13v2.0
Mc5r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391868,469,811 - 68,475,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1868,470,575 - 68,475,517 (+)EnsemblGRCm39 Ensembl
GRCm381868,336,744 - 68,342,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1868,337,596 - 68,342,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv371868,497,257 - 68,499,365 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361868,462,972 - 68,465,092 (+)NCBIMGSCv36mm8
Celera1869,645,563 - 69,647,671 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1841.46NCBI
Mc5r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81864,185,013 - 64,190,054 (+)NCBIGRCr8
mRatBN7.21861,915,188 - 61,920,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,915,188 - 61,920,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1863,990,228 - 63,995,268 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01864,695,178 - 64,700,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01862,539,890 - 62,544,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01864,113,659 - 64,118,700 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1864,114,933 - 64,116,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01863,329,399 - 63,330,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,679,384 - 64,680,417 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,752,231 - 64,753,823 (-)NCBI
Celera1860,019,520 - 60,020,553 (+)NCBICelera
RH 3.4 Map18628.5RGD
RH 3.4 Map18628.4RGD
Cytogenetic Map18q12.1NCBI
Mc5r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955402283,388 - 286,884 (-)NCBIChiLan1.0ChiLan1.0
MC5R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21724,217,275 - 24,222,385 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,907,321 - 9,914,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018495,561 - 501,555 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1182,668,281 - 2,669,586 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl182,668,394 - 2,669,371 (-)Ensemblpanpan1.1panPan2
Mc5r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049443,972,966 - 3,976,952 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366263,202,346 - 3,204,477 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366263,203,437 - 3,204,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MC5R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,322,422 - 96,323,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,322,276 - 96,323,795 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,672,688 - 89,674,974 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MC5R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11872,263,016 - 72,268,436 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1872,264,815 - 72,265,792 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,330,875 - 47,334,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in MC5R
61 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 12 6 12 8 9
Low 5 5 10 6 6 6 6 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845006145   ⟹   ENSCAFP00845004889
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl124,328,811 - 24,329,788 (-)Ensembl
RefSeq Acc Id: XM_005615400   ⟹   XP_005615457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1124,429,331 - 24,433,212 (-)NCBI
Dog10K_Boxer_Tasha125,410,285 - 25,414,162 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038465001   ⟹   XP_038320929
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1124,381,249 - 24,385,125 (-)NCBI
RefSeq Acc Id: XM_038525579   ⟹   XP_038381507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0124,538,879 - 24,544,347 (-)NCBI
RefSeq Acc Id: XM_038589784   ⟹   XP_038445712
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0124,267,632 - 24,271,507 (-)NCBI
RefSeq Acc Id: XM_038653708   ⟹   XP_038509636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0124,326,030 - 24,331,495 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005615457   ⟸   XM_005615400
- UniProtKB: A0A8P0N3F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038320929   ⟸   XM_038465001
RefSeq Acc Id: XP_038445712   ⟸   XM_038589784
RefSeq Acc Id: XP_038509636   ⟸   XM_038653708
- UniProtKB: A0A8I3MI44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381507   ⟸   XM_038525579
RefSeq Acc Id: ENSCAFP00845004889   ⟸   ENSCAFT00845006145
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000172 UniProtKB/TrEMBL
  ENSCAFG00845003464 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000277.5 UniProtKB/TrEMBL
  ENSCAFT00845006145 ENTREZGENE
  ENSCAFT00845006145.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  MC3-5R UniProtKB/TrEMBL
  Melancort_rcpt_5 UniProtKB/TrEMBL
  Melcrt_ACTH_rcpt UniProtKB/TrEMBL
KEGG Report cfa:483981 UniProtKB/TrEMBL
NCBI Gene MC5R ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR22750:SF5 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MCRFAMILY UniProtKB/TrEMBL
  MELNOCORTINR UniProtKB/TrEMBL
  MELNOCORTN5R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I3MI44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N3F9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43068 ENTREZGENE