CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) - Rat Genome Database
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Gene: CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) Canis lupus familiaris
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Symbol: CAD
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
RGD ID: 12151150
Description: ENCODES a protein that exhibits aspartate carbamoyltransferase activity (ortholog); carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (ortholog); dihydroorotase activity (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); animal organ regeneration (ortholog); cellular response to drug (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-ureidopropionase deficiency pathway; Canavan disease pathway; ASSOCIATED WITH Acute Erythroblastic Leukemia (ortholog); beta thalassemia (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN cell projection (ortholog); cytosol (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: CAD protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11721,198,839 - 21,221,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
CAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11721,198,839 - 21,221,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl227,217,369 - 27,243,943 (+)EnsemblGRCh38hg38GRCh38
GRCh38227,217,369 - 27,243,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37227,440,237 - 27,466,811 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37227,440,258 - 27,466,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,293,762 - 27,320,158 (+)NCBINCBI36hg18NCBI36
Build 34227,351,908 - 27,378,305NCBI
Celera227,286,585 - 27,312,981 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef227,181,964 - 27,208,360 (+)NCBIHuRef
CHM1_1227,370,163 - 27,396,565 (+)NCBICHM1_1
Cad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,211,964 - 31,235,823 (+)NCBIGRCm39mm39
GRCm38531,054,620 - 31,078,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,054,780 - 31,078,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,357,184 - 31,380,852 (+)NCBIGRCm37mm9NCBIm37
MGSCv36531,331,392 - 31,355,060 (+)NCBImm8
Celera528,526,834 - 28,551,927 (+)NCBICelera
Cytogenetic Map5B1NCBI
Cad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2625,292,133 - 25,315,176 (-)NCBI
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0626,657,507 - 26,680,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0636,472,498 - 36,495,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,272,416 - 25,296,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera624,783,039 - 24,805,943 (-)NCBICelera
Cytogenetic Map6q14NCBI
Cad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,203,434 - 9,227,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,203,433 - 9,227,526 (+)NCBIChiLan1.0ChiLan1.0
CAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A27,306,488 - 27,332,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,306,527 - 27,332,804 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A27,218,699 - 27,245,156 (+)NCBIMhudiblu_PPA_v0panPan3
Cad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364935,308,268 - 5,332,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,887,020 - 111,914,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,887,017 - 111,914,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CAD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,371,154 - 80,399,193 (-)NCBI
ChlSab1.1 Ensembl1480,371,096 - 80,398,914 (-)Ensembl
Cad
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247389,318,213 - 9,340,765 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 13 1 5 6 6
Low 5 5 9 6 5 6 1 6 6 8 4 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005630249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038452978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038498505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038498506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038498507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038561057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038561058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038561059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038625107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038625108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038625109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038691006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038691007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038691008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_540124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000007712   ⟹   ENSCAFP00000007145
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049604   ⟹   ENSCAFP00000039642
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089405   ⟹   ENSCAFP00000054919
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)Ensembl
RefSeq Acc Id: XM_005630249   ⟹   XP_005630306
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11721,199,116 - 21,221,897 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005630250   ⟹   XP_005630307
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11721,198,839 - 21,221,897 (+)NCBI
Sequence:
RefSeq Acc Id: XM_540124   ⟹   XP_540124
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11721,199,117 - 21,221,897 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005630307   ⟸   XM_005630250
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005630306   ⟸   XM_005630249
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_540124   ⟸   XM_540124
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000039642   ⟸   ENSCAFT00000049604
RefSeq Acc Id: ENSCAFP00000054919   ⟸   ENSCAFT00000089405
RefSeq Acc Id: ENSCAFP00000007145   ⟸   ENSCAFT00000007712

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004767 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000007145 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000039642 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000054919 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007712 UniProtKB/TrEMBL
  ENSCAFT00000049604 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000089405 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1030.10 UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/TrEMBL
  3.40.50.1370 UniProtKB/TrEMBL
  3.40.50.1380 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.50.30.20 UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Asp/Orn_carbamoyltranf_P-bd UniProtKB/TrEMBL
  Asp/Orn_carbamoylTrfase UniProtKB/TrEMBL
  Asp/Orn_carbamoylTrfase_sf UniProtKB/TrEMBL
  Asp_carbamoyltransf UniProtKB/TrEMBL
  Asp_carbamoyltransf_Asp/Orn-bd UniProtKB/TrEMBL
  ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  CarbamoylP_synth_lsu UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/TrEMBL
  CarbamoylP_synth_ssu UniProtKB/TrEMBL
  CarbamoylP_synth_ssu_N UniProtKB/TrEMBL
  CarbP_synth_ssu_N_sf UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/TrEMBL
  CbamoylP_synth_lsu_CPSase_dom UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/TrEMBL
  CPSase_GATase1 UniProtKB/TrEMBL
  Dihydroorotase_CS UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:483009 UniProtKB/TrEMBL
NCBI Gene CAD ENTREZGENE
Pfam Amidohydro_1 UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/TrEMBL
  CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  GATase UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
  OTCace UniProtKB/TrEMBL
  OTCace_N UniProtKB/TrEMBL
PRINTS AOTCASE UniProtKB/TrEMBL
  CPSASE UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  CARBAMOYLTRANSFERASE UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  DIHYDROOROTASE_1 UniProtKB/TrEMBL
  DIHYDROOROTASE_2 UniProtKB/TrEMBL
  GATASE_TYPE_1 UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
SMART CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
Superfamily-SCOP SSF48108 UniProtKB/TrEMBL
  SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
  SSF52021 UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
  SSF52335 UniProtKB/TrEMBL
  SSF52440 UniProtKB/TrEMBL
  SSF53671 UniProtKB/TrEMBL
TIGRFAMs asp_carb_tr UniProtKB/TrEMBL
  CPSaseII_lrg UniProtKB/TrEMBL
  CPSaseIIsmall UniProtKB/TrEMBL
UniProt A0A5F4CKZ2_CANLF UniProtKB/TrEMBL
  E2RAV2_CANLF UniProtKB/TrEMBL
  J9P266_CANLF UniProtKB/TrEMBL