MIR543 (microRNA mir-543) - Rat Genome Database

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Gene: MIR543 (microRNA mir-543) Canis lupus familiaris
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Symbol: MIR543
Name: microRNA mir-543
RGD ID: 12149814
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-543; microRNA 543
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,263,406 - 69,263,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,781,481 - 68,781,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,545,117 - 69,545,174 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,208,665 - 69,208,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,274,755 - 69,274,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,672,755 - 69,672,812 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR543
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,263,406 - 69,263,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,781,481 - 68,781,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,545,117 - 69,545,174 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,208,665 - 69,208,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,274,755 - 69,274,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,672,755 - 69,672,812 (+)NCBIUU_Cfam_GSD_1.0
MIR543
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,031,987 - 101,032,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,031,987 - 101,032,064 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,498,324 - 101,498,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1481,554,368 - 81,554,445 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,681,819 - 81,681,896 (+)NCBIHuRef
CHM1_114101,436,460 - 101,436,537 (+)NCBICHM1_1
T2T-CHM13v2.01495,267,443 - 95,267,520 (+)NCBIT2T-CHM13v2.0
Mir543
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,683,692 - 109,683,767 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,683,692 - 109,683,767 (+)EnsemblGRCm39 Ensembl
GRCm3812109,717,258 - 109,717,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,717,258 - 109,717,333 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,955,468 - 110,955,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,914,488 - 110,914,563 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system nervous system
High
Medium
Low 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: NR_049365
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1869,263,406 - 69,263,463 (+)NCBI
Dog10K_Boxer_Tasha868,781,481 - 68,781,538 (+)NCBI
ROS_Cfam_1.0869,545,117 - 69,545,174 (+)NCBI
UMICH_Zoey_3.1869,208,665 - 69,208,722 (+)NCBI
UNSW_CanFamBas_1.0869,274,755 - 69,274,812 (+)NCBI
UU_Cfam_GSD_1.0869,672,755 - 69,672,812 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00845005264 ENTREZGENE
Ensembl Transcript ENSCAFT00845009390 ENTREZGENE
miRBase MI0008139 ENTREZGENE
NCBI Gene MIR543 ENTREZGENE
RNAcentral URS000019F055 RNACentral
  URS00007E4686 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR543  microRNA mir-543    microRNA 543  Symbol and/or name change 5135510 APPROVED