NFKBIE (NFKB inhibitor epsilon) - Rat Genome Database

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Gene: NFKBIE (NFKB inhibitor epsilon) Canis lupus familiaris
Analyze
Symbol: NFKBIE
Name: NFKB inhibitor epsilon
RGD ID: 12149213
Description: ENCODES a protein that exhibits NF-kappaB binding (inferred); INVOLVED IN D-serine transmembrane transport (ortholog); PARTICIPATES IN nuclear factor kappa B signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); melanoma (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NF-kappa-B inhibitor epsilon; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,668,664 - 12,674,146 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,694,054 - 12,702,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01213,151,713 - 13,160,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1213,151,717 - 13,160,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,677,143 - 12,685,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,764,624 - 12,772,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,858,827 - 12,867,147 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NFKBIE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,668,664 - 12,674,146 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,694,054 - 12,702,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01213,151,713 - 13,160,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1213,151,717 - 13,160,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,677,143 - 12,685,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,764,624 - 12,772,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,858,827 - 12,867,147 (-)NCBIUU_Cfam_GSD_1.0
NFKBIE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,258,166 - 44,265,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl644,258,166 - 44,265,788 (-)EnsemblGRCh38hg38GRCh38
GRCh37644,225,903 - 44,233,288 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,333,881 - 44,341,503 (-)NCBINCBI36Build 36hg18NCBI36
Build 34644,334,404 - 44,341,503NCBI
Celera645,779,052 - 45,786,678 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,947,918 - 43,955,542 (-)NCBIHuRef
CHM1_1644,229,610 - 44,237,246 (-)NCBICHM1_1
T2T-CHM13v2.0644,092,317 - 44,099,688 (-)NCBIT2T-CHM13v2.0
Nfkbie
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,866,626 - 45,874,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1745,866,629 - 45,874,095 (+)EnsemblGRCm39 Ensembl
GRCm381745,555,700 - 45,563,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,555,703 - 45,563,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv371745,692,665 - 45,700,118 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,019,297 - 45,026,750 (+)NCBIMGSCv36mm8
Celera1748,988,415 - 48,995,813 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1722.58NCBI
Nfkbie
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,941,037 - 22,947,872 (-)NCBIGRCr8
mRatBN7.2915,443,600 - 15,450,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,436,941 - 15,450,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,030,126 - 24,036,913 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,092,803 - 29,099,590 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,393,565 - 27,400,352 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,828,405 - 17,835,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,828,408 - 17,835,240 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,717,126 - 16,723,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,044,112 - 11,050,948 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,041,436 - 11,048,270 (-)NCBI
Celera913,186,838 - 13,193,673 (-)NCBICelera
Cytogenetic Map9q12NCBI
Nfkbie
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,882,460 - 9,888,952 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,882,460 - 9,888,848 (-)NCBIChiLan1.0ChiLan1.0
NFKBIE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,762,193 - 58,772,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1654,632,285 - 54,642,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,853,921 - 43,861,686 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1645,137,160 - 45,144,699 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,138,209 - 45,144,680 (-)Ensemblpanpan1.1panPan2
Nfkbie
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,134,122 - 48,141,644 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647615,818,554 - 15,826,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647615,818,605 - 15,825,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,255,075 - 39,263,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1739,255,078 - 39,266,085 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,124,531 - 45,133,184 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,901,990 - 27,909,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1727,902,389 - 27,910,440 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604444,312,243 - 44,319,949 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbie
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475415,593,765 - 15,605,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475415,593,755 - 15,605,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NFKBIE
73 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1 5 4
Low 5 5 21 6 6 6 5 3 7 3 6 6
Below cutoff 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845020768   ⟹   ENSCAFP00845016291
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1213,151,717 - 13,160,137 (-)Ensembl
RefSeq Acc Id: XM_038491932   ⟹   XP_038347860
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11212,677,143 - 12,685,399 (-)NCBI
RefSeq Acc Id: XM_038554197   ⟹   XP_038410125
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01212,858,827 - 12,867,147 (-)NCBI
RefSeq Acc Id: XM_038618064   ⟹   XP_038473992
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01212,764,624 - 12,772,929 (-)NCBI
RefSeq Acc Id: XM_038671489   ⟹   XP_038527417
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1212,694,054 - 12,702,366 (-)NCBI
RefSeq Acc Id: XM_038683660   ⟹   XP_038539588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01213,151,713 - 13,160,030 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038347860   ⟸   XM_038491932
RefSeq Acc Id: XP_038473992   ⟸   XM_038618064
RefSeq Acc Id: XP_038539588   ⟸   XM_038683660
- UniProtKB: A0A8C0MM82 (UniProtKB/TrEMBL),   A0A8I3N908 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038527417   ⟸   XM_038671489
- UniProtKB: A0A8C0KEA1 (UniProtKB/TrEMBL),   A0A8P0N523 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410125   ⟸   XM_038554197
- UniProtKB: A0A8C0KEA1 (UniProtKB/TrEMBL),   A0A8P0N523 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016291   ⟸   ENSCAFT00845020768


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001985 UniProtKB/TrEMBL
  ENSCAFG00030008631 UniProtKB/TrEMBL
  ENSCAFG00845011706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003140.5 UniProtKB/TrEMBL
  ENSCAFT00030015927.1 UniProtKB/TrEMBL
  ENSCAFT00845020768 ENTREZGENE
  ENSCAFT00845020768.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
NCBI Gene NFKBIE ENTREZGENE
PANTHER NF-KAPPA-B INHIBITOR ALPHA UniProtKB/TrEMBL
  NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A8C0KEA1 ENTREZGENE
  A0A8C0MM82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N908 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N523 ENTREZGENE, UniProtKB/TrEMBL