PPP1R21 (protein phosphatase 1 regulatory subunit 21) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PPP1R21 (protein phosphatase 1 regulatory subunit 21) Canis lupus familiaris
Analyze
Symbol: PPP1R21 (Ensembl: STON1)
Name: protein phosphatase 1 regulatory subunit 21
RGD ID: 12146118
Description: ASSOCIATED WITH genetic disease (ortholog); NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, FACIAL DYSMORPHISM, AND BRAIN ABNORMALITIES (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN early endosome (inferred); endosome (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CCDC128; coiled-coil domain containing 128; KLRAQ motif containing 1; KLRAQ1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11050,350,521 - 50,415,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,350,545 - 50,415,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1050,204,226 - 50,269,500 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01051,229,673 - 51,295,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,929,749 - 50,995,045 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,216,609 - 51,281,750 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,405,081 - 51,470,229 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
early endosome  (IEA)
endosome  (IEA)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PPP1R21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11050,350,521 - 50,415,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,350,545 - 50,415,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1050,204,226 - 50,269,500 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01051,229,673 - 51,295,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,929,749 - 50,995,045 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,216,609 - 51,281,750 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,405,081 - 51,470,229 (+)NCBIUU_Cfam_GSD_1.0
PPP1R21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38248,440,766 - 48,515,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl248,440,598 - 48,515,391 (+)EnsemblGRCh38hg38GRCh38
GRCh37248,667,905 - 48,742,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36248,521,412 - 48,596,029 (+)NCBINCBI36Build 36hg18NCBI36
Celera248,507,697 - 48,582,287 (+)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef248,403,647 - 48,478,111 (+)NCBIHuRef
CHM1_1248,598,083 - 48,672,622 (+)NCBICHM1_1
T2T-CHM13v2.0248,446,714 - 48,521,263 (+)NCBIT2T-CHM13v2.0
Ppp1r21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,837,552 - 88,895,795 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,837,546 - 88,895,795 (+)EnsemblGRCm39 Ensembl
GRCm381788,530,124 - 88,588,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,530,118 - 88,588,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv371788,929,464 - 88,987,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361788,438,587 - 88,496,691 (+)NCBIMGSCv36mm8
Celera1792,948,195 - 93,006,786 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1758.02NCBI
Ppp1r21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,655,059 - 11,724,219 (-)NCBIGRCr8
mRatBN7.265,901,518 - 5,970,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,901,518 - 5,970,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,184,768 - 6,254,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,494,144 - 6,563,384 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,021,317 - 6,090,561 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,253,788 - 12,323,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,253,788 - 12,323,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0622,270,224 - 22,286,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0622,219,113 - 22,263,931 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4612,360,976 - 12,405,728 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera65,674,130 - 5,741,099 (-)NCBICelera
Cytogenetic Map6q12NCBI
Ppp1r21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544115,004,888 - 15,061,967 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544115,002,126 - 15,061,967 (+)NCBIChiLan1.0ChiLan1.0
PPP1R21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21277,862,209 - 77,936,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A77,866,179 - 77,940,513 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A48,568,114 - 48,642,401 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A49,489,967 - 49,563,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A49,489,967 - 49,563,464 (+)Ensemblpanpan1.1panPan2
Ppp1r21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629232,698,552 - 32,765,112 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,125,444 - 4,193,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,127,373 - 4,193,206 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,156,008 - 92,227,708 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1392,156,002 - 92,227,719 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2397,965,691 - 98,036,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11458,649,556 - 58,723,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1458,648,748 - 58,723,553 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604553,125,831 - 53,196,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,662,864 - 29,737,676 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473829,662,619 - 29,785,679 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP1R21
608 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 12 3 2 12 10 2
Low 5 5 10 6 3 6 4 6 8 4
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000036478   ⟹   ENSCAFP00000031860
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1050,350,545 - 50,415,260 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000036481   ⟹   ENSCAFP00000031863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1050,350,545 - 50,415,732 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000071993   ⟹   ENSCAFP00000045778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1050,350,545 - 50,415,732 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010181   ⟹   ENSCAFP00845007936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010197   ⟹   ENSCAFP00845007947
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010279   ⟹   ENSCAFP00845008006
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010346   ⟹   ENSCAFP00845008044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010402   ⟹   ENSCAFP00845008083
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)Ensembl
RefSeq Acc Id: XM_038489239   ⟹   XP_038345167
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11050,929,749 - 50,995,045 (+)NCBI
RefSeq Acc Id: XM_038551242   ⟹   XP_038407170
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01051,405,081 - 51,470,229 (+)NCBI
RefSeq Acc Id: XM_038615138   ⟹   XP_038471066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01051,216,609 - 51,281,750 (+)NCBI
RefSeq Acc Id: XM_038680521   ⟹   XP_038536449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01051,229,673 - 51,295,006 (+)NCBI
RefSeq Acc Id: XM_531815   ⟹   XP_531815
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11050,350,521 - 50,415,803 (+)NCBI
Dog10K_Boxer_Tasha1050,204,226 - 50,269,500 (+)NCBI
Sequence:
RefSeq Acc Id: XP_531815   ⟸   XM_531815
- UniProtKB: A0A8C0LRF2 (UniProtKB/TrEMBL),   A0A8I3MZ61 (UniProtKB/TrEMBL),   A0A8P0NLS1 (UniProtKB/TrEMBL),   A0A8C0SH09 (UniProtKB/TrEMBL),   A0A8I3MWR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000031863   ⟸   ENSCAFT00000036481
RefSeq Acc Id: ENSCAFP00000031860   ⟸   ENSCAFT00000036478
RefSeq Acc Id: ENSCAFP00000045778   ⟸   ENSCAFT00000071993
RefSeq Acc Id: XP_038345167   ⟸   XM_038489239
RefSeq Acc Id: XP_038471066   ⟸   XM_038615138
RefSeq Acc Id: XP_038536449   ⟸   XM_038680521
- UniProtKB: A0A8C0LRF2 (UniProtKB/TrEMBL),   A0A8I3MZ61 (UniProtKB/TrEMBL),   A0A8P0NLS1 (UniProtKB/TrEMBL),   A0A8C0SH09 (UniProtKB/TrEMBL),   A0A8I3MWR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407170   ⟸   XM_038551242
- UniProtKB: A0A8C0LRF2 (UniProtKB/TrEMBL),   A0A8C0SH09 (UniProtKB/TrEMBL),   A0A8I3MWR0 (UniProtKB/TrEMBL),   A0A8I3MZ61 (UniProtKB/TrEMBL),   A0A8P0NLS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007947   ⟸   ENSCAFT00845010197
RefSeq Acc Id: ENSCAFP00845008006   ⟸   ENSCAFT00845010279
RefSeq Acc Id: ENSCAFP00845008044   ⟸   ENSCAFT00845010346
RefSeq Acc Id: ENSCAFP00845008083   ⟸   ENSCAFT00845010402
RefSeq Acc Id: ENSCAFP00845007936   ⟸   ENSCAFT00845010181
Promoters
RGD ID:13685062
Promoter ID:EPDNEW_C3129
Type:initiation region
Name:PPP1R21_1
Description:protein phosphatase 1 regulatory subunit 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11050,350,566 - 50,350,626EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002688 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008417 UniProtKB/TrEMBL
  ENSCAFG00040012806 UniProtKB/TrEMBL
  ENSCAFG00845005733 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000036478.3 UniProtKB/TrEMBL
  ENSCAFT00000036481.5 UniProtKB/TrEMBL
  ENSCAFT00000071993.2 UniProtKB/TrEMBL
  ENSCAFT00000100403.1 UniProtKB/TrEMBL
  ENSCAFT00000103779.1 UniProtKB/TrEMBL
  ENSCAFT00030015703.1 UniProtKB/TrEMBL
  ENSCAFT00040024145.1 UniProtKB/TrEMBL
  ENSCAFT00845010181 ENTREZGENE
  ENSCAFT00845010181.1 UniProtKB/TrEMBL
  ENSCAFT00845010197.1 UniProtKB/TrEMBL
  ENSCAFT00845010279.1 UniProtKB/TrEMBL
  ENSCAFT00845010346.1 UniProtKB/TrEMBL
  ENSCAFT00845010402.1 UniProtKB/TrEMBL
InterPro KLRAQ/TTKRSYEDQ_C UniProtKB/TrEMBL
  PPP1R21 UniProtKB/TrEMBL
  PPP1R21_C UniProtKB/TrEMBL
  Unchr_KLRAQ/TTKRSYEDQ_N UniProtKB/TrEMBL
KEGG Report cfa:474586 UniProtKB/TrEMBL
NCBI Gene PPP1R21 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21 UniProtKB/TrEMBL
  PTHR21448 UniProtKB/TrEMBL
Pfam KLRAQ UniProtKB/TrEMBL
  PPP1R21_C UniProtKB/TrEMBL
  TTKRSYEDQ UniProtKB/TrEMBL
SMART KLRAQ UniProtKB/TrEMBL
UniProt A0A8C0LRF2 ENTREZGENE
  A0A8C0SH09 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MUQ7_CANLF UniProtKB/TrEMBL
  A0A8I3MWR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZ61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZD6_CANLF UniProtKB/TrEMBL
  A0A8I3NCP3_CANLF UniProtKB/TrEMBL
  A0A8P0NLS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NW15_CANLF UniProtKB/TrEMBL
  A0A8P0PHK3_CANLF UniProtKB/TrEMBL
  A0A8P0TK57_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44889 ENTREZGENE