PLA2G7 (phospholipase A2 group VII) - Rat Genome Database

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Gene: PLA2G7 (phospholipase A2 group VII) Canis lupus familiaris
Analyze
Symbol: PLA2G7
Name: phospholipase A2 group VII
RGD ID: 12144916
Description: ENCODES a protein that exhibits 1-alkyl-2-acetylglycerophosphocholine esterase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); INVOLVED IN phosphatidylcholine catabolic process (ortholog); platelet activating factor catabolic process (ortholog); platelet activating factor metabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); asthma (ortholog); FOUND IN extracellular space (ortholog); high-density lipoprotein particle (ortholog); low-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; LDL-associated phospholipase A2; LDL-PLA(2); PAF 2-acylhydrolase; PAF acetylhydrolase; plasma PAF acetylhydrolase; platelet-activating factor acetylhydrolase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,866,229 - 14,908,230 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,866,229 - 14,908,114 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,897,517 - 14,938,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,366,067 - 15,408,199 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,366,063 - 15,408,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,881,621 - 14,922,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,970,576 - 15,012,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,117,009 - 15,158,322 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:7592717   PMID:7700381   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLA2G7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,866,229 - 14,908,230 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,866,229 - 14,908,114 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,897,517 - 14,938,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,366,067 - 15,408,199 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,366,063 - 15,408,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,881,621 - 14,922,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,970,576 - 15,012,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,117,009 - 15,158,322 (-)NCBIUU_Cfam_GSD_1.0
PLA2G7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,704,201 - 46,735,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,704,201 - 46,735,693 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,671,938 - 46,703,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,780,237 - 46,811,061 (-)NCBINCBI36Build 36hg18NCBI36
Build 34646,780,236 - 46,811,055NCBI
Celera648,224,575 - 48,255,899 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,395,325 - 46,426,641 (-)NCBIHuRef
CHM1_1646,675,466 - 46,706,812 (-)NCBICHM1_1
T2T-CHM13v2.0646,541,848 - 46,573,478 (-)NCBIT2T-CHM13v2.0
Pla2g7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,879,009 - 43,923,093 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,878,989 - 43,923,092 (+)EnsemblGRCm39 Ensembl
GRCm381743,567,994 - 43,612,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,568,098 - 43,612,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371743,705,400 - 43,749,150 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,031,500 - 43,075,242 (+)NCBIMGSCv36mm8
Celera1746,991,155 - 47,035,006 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.74NCBI
Pla2g7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,859,491 - 24,901,747 (-)NCBIGRCr8
mRatBN7.2917,362,214 - 17,404,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,362,225 - 17,404,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,952,093 - 25,994,494 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,026,641 - 31,069,054 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0929,315,869 - 29,358,274 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,935,754 - 19,978,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,935,768 - 19,978,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,813,216 - 18,855,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,057,988 - 13,100,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,055,311 - 13,097,611 (-)NCBI
Celera915,085,734 - 15,127,419 (-)NCBICelera
Cytogenetic Map9q13NCBI
Pla2g7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,534,173 - 11,555,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,534,251 - 11,577,942 (-)NCBIChiLan1.0ChiLan1.0
PLA2G7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,165,585 - 61,231,060 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,031,715 - 57,097,254 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0646,264,262 - 46,318,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,558,861 - 47,590,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,558,861 - 47,590,212 (-)Ensemblpanpan1.1panPan2
Pla2g7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,314,028 - 50,350,357 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,609,374 - 13,649,998 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647613,609,847 - 13,646,174 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl741,486,598 - 41,531,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1741,488,152 - 41,531,383 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,149,037 - 48,192,545 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,538,645 - 25,571,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,538,438 - 25,574,269 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,721,234 - 46,754,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,904,797 - 13,931,670 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,905,084 - 13,932,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G7
490 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005627023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005627024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005627025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005627026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022425715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000003227   ⟹   ENSCAFP00000002999
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1214,866,229 - 14,907,727 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000035365   ⟹   ENSCAFP00000030617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1214,866,229 - 14,906,303 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000083710   ⟹   ENSCAFP00000058629
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1214,866,229 - 14,908,114 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845023437   ⟹   ENSCAFP00845018393
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1215,366,063 - 15,408,686 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845023497   ⟹   ENSCAFP00845018443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1215,366,063 - 15,385,831 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845023556   ⟹   ENSCAFP00845018494
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1215,366,067 - 15,407,680 (-)Ensembl
RefSeq Acc Id: NM_001003198   ⟹   NP_001003198
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11214,866,229 - 14,907,727 (-)NCBI
Dog10K_Boxer_Tasha1214,897,517 - 14,938,972 (-)NCBI
ROS_Cfam_1.01215,366,067 - 15,407,680 (-)NCBI
UMICH_Zoey_3.11214,881,621 - 14,922,982 (-)NCBI
UNSW_CanFamBas_1.01214,970,576 - 15,012,067 (-)NCBI
UU_Cfam_GSD_1.01215,117,009 - 15,158,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038682684   ⟹   XP_038538612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01215,366,738 - 15,407,726 (-)NCBI
RefSeq Acc Id: XM_038682685   ⟹   XP_038538613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01215,366,067 - 15,385,818 (-)NCBI
RefSeq Acc Id: XM_038682686   ⟹   XP_038538614
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01215,366,738 - 15,408,199 (-)NCBI
RefSeq Acc Id: XM_038682687   ⟹   XP_038538615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01215,366,738 - 15,407,749 (-)NCBI
RefSeq Acc Id: XM_038682688   ⟹   XP_038538616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01215,366,738 - 15,408,193 (-)NCBI
RefSeq Acc Id: NP_001003198   ⟸   NM_001003198
- Peptide Label: precursor
- UniProtKB: Q28262 (UniProtKB/Swiss-Prot),   A0A8C0KFN3 (UniProtKB/TrEMBL),   A0A8C0SID2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000030617   ⟸   ENSCAFT00000035365
Ensembl Acc Id: ENSCAFP00000058629   ⟸   ENSCAFT00000083710
Ensembl Acc Id: ENSCAFP00000002999   ⟸   ENSCAFT00000003227
RefSeq Acc Id: XP_038538613   ⟸   XM_038682685
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SI19 (UniProtKB/TrEMBL),   A0A8I3NR68 (UniProtKB/TrEMBL),   A0A8C0SHH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538614   ⟸   XM_038682686
- Peptide Label: isoform X2
- UniProtKB: A0A8C0YXG5 (UniProtKB/TrEMBL),   A0A8I3NLB2 (UniProtKB/TrEMBL),   A0A8C0SID2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538616   ⟸   XM_038682688
- Peptide Label: isoform X3
- UniProtKB: A0A8C0RE06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538615   ⟸   XM_038682687
- Peptide Label: isoform X2
- UniProtKB: A0A8C0YXG5 (UniProtKB/TrEMBL),   A0A8I3NLB2 (UniProtKB/TrEMBL),   A0A8C0SID2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538612   ⟸   XM_038682684
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SI19 (UniProtKB/TrEMBL),   A0A8I3NR68 (UniProtKB/TrEMBL),   A0A8C0SHH7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845018443   ⟸   ENSCAFT00845023497
Ensembl Acc Id: ENSCAFP00845018494   ⟸   ENSCAFT00845023556
Ensembl Acc Id: ENSCAFP00845018393   ⟸   ENSCAFT00845023437

Promoters
RGD ID:13685452
Promoter ID:EPDNEW_C3520
Type:initiation region
Name:PLA2G7_1
Description:phospholipase A2 group VII
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11214,907,774 - 14,907,834EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002037 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040013217 UniProtKB/TrEMBL
  ENSCAFG00805015251 UniProtKB/Swiss-Prot
  ENSCAFG00845013082 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003227.2 UniProtKB/TrEMBL
  ENSCAFT00000035365.5 UniProtKB/TrEMBL
  ENSCAFT00030011713.1 UniProtKB/TrEMBL
  ENSCAFT00030011773.1 UniProtKB/Swiss-Prot
  ENSCAFT00030011797.1 UniProtKB/TrEMBL
  ENSCAFT00030011845.1 UniProtKB/TrEMBL
  ENSCAFT00040024438.1 UniProtKB/TrEMBL
  ENSCAFT00040024616.1 UniProtKB/TrEMBL
  ENSCAFT00040024638.1 UniProtKB/TrEMBL
  ENSCAFT00040024680.1 UniProtKB/TrEMBL
  ENSCAFT00805027835 UniProtKB/Swiss-Prot
  ENSCAFT00845023437.1 UniProtKB/TrEMBL
  ENSCAFT00845023497 ENTREZGENE
  ENSCAFT00845023497.1 UniProtKB/TrEMBL
  ENSCAFT00845023556 ENTREZGENE
  ENSCAFT00845023556.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAF_acetylhydro_eucaryote UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403848 UniProtKB/Swiss-Prot
NCBI Gene PLA2G7 ENTREZGENE
PANTHER PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10272 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAF-AH_p_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF PAF_acetylhydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0KFN3 ENTREZGENE
  A0A8C0ME16_CANLF UniProtKB/TrEMBL
  A0A8C0RDY5_CANLF UniProtKB/TrEMBL
  A0A8C0RE06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SHH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SI19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SID2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YXG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NLB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NR68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RXD7_CANLF UniProtKB/TrEMBL
  PAFA_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:44632 ENTREZGENE