MIP (major intrinsic protein of lens fiber) - Rat Genome Database

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Gene: MIP (major intrinsic protein of lens fiber) Canis lupus familiaris
Analyze
Symbol: MIP
Name: major intrinsic protein of lens fiber
RGD ID: 12141984
Description: ENCODES a protein that exhibits calmodulin binding (ortholog); water channel activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); gap junction-mediated intercellular transport (ortholog); lens development in camera-type eye (ortholog); ASSOCIATED WITH cataract (ortholog); cataract 15 multiple types (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); intracellular canaliculus (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aquaporin-0; lens fiber major intrinsic protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110701,385 - 707,005 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10701,387 - 706,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10764,593 - 769,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010710,356 - 715,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10710,358 - 715,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110687,429 - 692,195 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010930,541 - 935,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,054,262 - 1,059,027 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110701,385 - 707,005 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10701,387 - 706,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10764,593 - 769,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010710,356 - 715,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10710,358 - 715,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110687,429 - 692,195 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010930,541 - 935,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,054,262 - 1,059,027 (-)NCBIUU_Cfam_GSD_1.0
MIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,449,502 - 56,456,553 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,449,502 - 56,469,166 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,843,286 - 56,848,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,130,151 - 55,134,696 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,131,148 - 55,134,709NCBI
Celera1256,496,656 - 56,501,806 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,882,327 - 53,887,476 (-)NCBIHuRef
CHM1_11256,810,895 - 56,816,045 (-)NCBICHM1_1
T2T-CHM13v2.01256,417,213 - 56,424,265 (-)NCBIT2T-CHM13v2.0
Mip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,061,679 - 128,067,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,061,707 - 128,067,681 (+)EnsemblGRCm39 Ensembl
GRCm3810128,225,810 - 128,231,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,225,838 - 128,231,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,662,894 - 127,668,867 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,628,787 - 127,634,760 (+)NCBIMGSCv36mm8
Celera10133,261,918 - 133,267,869 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.49NCBI
Mip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,228,089 - 1,237,707 (+)NCBIGRCr8
mRatBN7.27643,502 - 653,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7647,315 - 654,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,405,806 - 3,411,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,281,813 - 5,287,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,583,723 - 5,589,495 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,635,743 - 2,642,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,635,743 - 2,642,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,614,619 - 2,621,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,509,023 - 1,516,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,509,073 - 1,514,815 (+)NCBI
Celera7525,859 - 533,134 (+)NCBICelera
RH 3.4 Map10194.71RGD
Cytogenetic Map7q11NCBI
Mip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,030,619 - 4,035,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,030,619 - 4,035,656 (-)NCBIChiLan1.0ChiLan1.0
MIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,876,677 - 37,882,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,873,442 - 37,878,910 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,459,965 - 32,465,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,713,470 - 32,718,026 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,713,470 - 32,718,026 (+)Ensemblpanpan1.1panPan2
Mip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,058,559 - 58,063,768 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646807,856 - 811,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646806,467 - 811,676 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,787,826 - 21,793,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,789,040 - 21,804,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,334,531 - 23,339,133 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,409,592 - 52,415,752 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,410,325 - 52,413,933 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,568,279 - 193,573,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,600,405 - 11,603,502 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,600,405 - 11,603,502 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MIP
33 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 1 1 1 8 2
Below cutoff 5 5 17 3 6 3 5 5 9 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000211   ⟹   ENSCAFP00000000190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10701,387 - 706,151 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014597   ⟹   ENSCAFP00845011311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10710,358 - 715,134 (-)Ensembl
RefSeq Acc Id: NM_001313795   ⟹   NP_001300724
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110702,110 - 706,151 (-)NCBI
Dog10K_Boxer_Tasha10765,318 - 769,360 (-)NCBI
ROS_Cfam_1.010711,081 - 715,134 (-)NCBI
UMICH_Zoey_3.110688,154 - 692,195 (-)NCBI
UNSW_CanFamBas_1.010931,266 - 935,310 (-)NCBI
UU_Cfam_GSD_1.0101,054,987 - 1,059,027 (-)NCBI
Sequence:
RefSeq Acc Id: NR_132651
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110701,385 - 706,151 (-)NCBI
Dog10K_Boxer_Tasha10764,593 - 769,360 (-)NCBI
ROS_Cfam_1.010710,356 - 715,134 (-)NCBI
UMICH_Zoey_3.110687,429 - 692,195 (-)NCBI
UNSW_CanFamBas_1.010930,541 - 935,310 (-)NCBI
UU_Cfam_GSD_1.0101,054,262 - 1,059,027 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038678796   ⟹   XP_038534724
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010710,356 - 715,983 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001300724   ⟸   NM_001313795
- UniProtKB: A2IBY8 (UniProtKB/Swiss-Prot),   A0A8C0LFK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000190   ⟸   ENSCAFT00000000211
RefSeq Acc Id: XP_038534724   ⟸   XM_038678796
- Peptide Label: isoform X1
- UniProtKB: A2IBY8 (UniProtKB/Swiss-Prot),   A0A8C0LFK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011311   ⟸   ENSCAFT00845014597


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000128 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030013268 UniProtKB/Swiss-Prot
  ENSCAFG00040006058 UniProtKB/Swiss-Prot
  ENSCAFG00805015080 UniProtKB/Swiss-Prot
  ENSCAFG00845008298 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000000211.5 UniProtKB/Swiss-Prot
  ENSCAFT00030024559.1 UniProtKB/Swiss-Prot
  ENSCAFT00040011312.1 UniProtKB/Swiss-Prot
  ENSCAFT00805027374 UniProtKB/Swiss-Prot
  ENSCAFT00845014597 ENTREZGENE
  ENSCAFT00845014597.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot
InterPro Aquaporin-like UniProtKB/Swiss-Prot
  Aquaporin_transptr UniProtKB/Swiss-Prot
  MIP UniProtKB/Swiss-Prot
  MIP_CS UniProtKB/Swiss-Prot
KEGG Report cfa:607104 UniProtKB/Swiss-Prot
NCBI Gene MIP ENTREZGENE
PANTHER LENS FIBER MAJOR INTRINSIC PROTEIN UniProtKB/Swiss-Prot
  PTHR19139 UniProtKB/Swiss-Prot
Pfam MIP UniProtKB/Swiss-Prot
PRINTS AQUAPORIN2 UniProtKB/Swiss-Prot
  MINTRINSICP UniProtKB/Swiss-Prot
PROSITE MIP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot
UniProt A0A8C0LFK7 ENTREZGENE
  A2IBY8 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:43241 ENTREZGENE