DGKE (diacylglycerol kinase epsilon) - Rat Genome Database

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Gene: DGKE (diacylglycerol kinase epsilon) Canis lupus familiaris
Analyze
Symbol: DGKE
Name: diacylglycerol kinase epsilon
RGD ID: 12140085
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent diacylglycerol kinase activity (inferred); kinase activity (inferred); INVOLVED IN diacylglycerol metabolic process (inferred); glycerolipid metabolic process (inferred); lipid metabolic process (inferred); ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); genetic disease (ortholog); hemolytic-uremic syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,666,727 - 31,690,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl931,667,101 - 31,685,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,906,562 - 30,930,717 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,474,399 - 32,498,584 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,474,438 - 32,496,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,259,562 - 31,283,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,543,810 - 31,567,997 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,627,097 - 31,651,293 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DGKE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,666,727 - 31,690,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl931,667,101 - 31,685,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,906,562 - 30,930,717 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,474,399 - 32,498,584 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,474,438 - 32,496,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,259,562 - 31,283,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,543,810 - 31,567,997 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,627,097 - 31,651,293 (+)NCBIUU_Cfam_GSD_1.0
DGKE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381756,834,151 - 56,869,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1756,834,107 - 56,869,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371754,911,512 - 54,946,928 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,266,552 - 52,295,922 (+)NCBINCBI36Build 36hg18NCBI36
Build 341752,266,551 - 52,295,922NCBI
Celera1751,373,022 - 51,407,618 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1750,271,649 - 50,306,289 (+)NCBIHuRef
CHM1_11754,976,592 - 55,011,187 (+)NCBICHM1_1
T2T-CHM13v2.01757,711,341 - 57,746,838 (+)NCBIT2T-CHM13v2.0
Dgke
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391188,926,005 - 88,951,644 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1188,926,005 - 88,957,676 (-)EnsemblGRCm39 Ensembl
GRCm381189,035,179 - 89,060,795 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,035,179 - 89,066,850 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,898,896 - 88,922,062 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,856,822 - 88,876,475 (-)NCBIMGSCv36mm8
Celera1198,654,397 - 98,682,111 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
Dgke
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81074,348,931 - 74,374,509 (-)NCBIGRCr8
mRatBN7.21073,853,030 - 73,877,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1073,855,583 - 73,877,100 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,476,905 - 78,501,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01077,981,833 - 78,006,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01073,445,002 - 73,469,271 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01076,375,981 - 76,408,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,386,471 - 76,407,989 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,703,580 - 73,729,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,513,434 - 77,534,864 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1072,759,901 - 72,781,417 (-)NCBICelera
Cytogenetic Map10q26NCBI
Dgke
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554515,969,070 - 5,988,004 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554515,966,773 - 5,988,004 (-)NCBIChiLan1.0ChiLan1.0
DGKE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21973,007,759 - 73,061,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11777,818,739 - 77,872,921 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01750,912,079 - 50,946,655 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11755,773,896 - 55,803,315 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,773,896 - 55,802,485 (+)Ensemblpanpan1.1panPan2
DGKE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1233,141,505 - 33,172,405 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11233,141,439 - 33,172,412 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21234,090,097 - 34,122,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGKE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,540,155 - 36,575,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1636,546,670 - 36,574,820 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660777,353,610 - 7,396,272 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgke
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479511,908,793 - 11,933,125 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479511,908,738 - 11,934,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DGKE
210 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 12 2
Low 5 5 16 6 6 6 6 6 8 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027545   ⟹   ENSCAFP00000025617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl931,667,101 - 31,685,464 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845031882   ⟹   ENSCAFP00845024937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl932,474,438 - 32,496,402 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032026   ⟹   ENSCAFP00845025044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl932,474,438 - 32,496,402 (+)Ensembl
RefSeq Acc Id: XM_038486025   ⟹   XP_038341953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1931,259,562 - 31,283,750 (+)NCBI
RefSeq Acc Id: XM_038547806   ⟹   XP_038403734
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0931,627,097 - 31,651,293 (+)NCBI
RefSeq Acc Id: XM_038611788   ⟹   XP_038467716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0931,543,810 - 31,567,997 (+)NCBI
RefSeq Acc Id: XM_038677012   ⟹   XP_038532940
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0932,474,399 - 32,498,584 (+)NCBI
RefSeq Acc Id: XM_548222   ⟹   XP_548222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1931,666,727 - 31,690,878 (+)NCBI
Dog10K_Boxer_Tasha930,906,562 - 30,930,717 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_548222   ⟸   XM_548222
- UniProtKB: A0A8C0LPT1 (UniProtKB/TrEMBL),   A0A8C0MX95 (UniProtKB/TrEMBL),   A0A8I3PA16 (UniProtKB/TrEMBL),   A0A8I3S093 (UniProtKB/TrEMBL),   A0A8P0PIT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000025617   ⟸   ENSCAFT00000027545
RefSeq Acc Id: XP_038341953   ⟸   XM_038486025
RefSeq Acc Id: XP_038467716   ⟸   XM_038611788
RefSeq Acc Id: XP_038532940   ⟸   XM_038677012
- UniProtKB: A0A8C0LPT1 (UniProtKB/TrEMBL),   A0A8C0MX95 (UniProtKB/TrEMBL),   A0A8I3PA16 (UniProtKB/TrEMBL),   A0A8I3S093 (UniProtKB/TrEMBL),   A0A8P0PIT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403734   ⟸   XM_038547806
- UniProtKB: A0A8C0LPT1 (UniProtKB/TrEMBL),   A0A8C0MX95 (UniProtKB/TrEMBL),   A0A8I3PA16 (UniProtKB/TrEMBL),   A0A8I3S093 (UniProtKB/TrEMBL),   A0A8P0PIT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845025044   ⟸   ENSCAFT00845032026
RefSeq Acc Id: ENSCAFP00845024937   ⟸   ENSCAFT00845031882
Protein Domains
DAGKc   Phorbol-ester/DAG-type

Promoters
RGD ID:13684610
Promoter ID:EPDNEW_C2677
Type:multiple initiation site
Name:DGKE_1
Description:diacylglycerol kinase epsilon
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1931,666,638 - 31,666,698EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017384 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011220 UniProtKB/TrEMBL
  ENSCAFG00845018012 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027545.5 UniProtKB/TrEMBL
  ENSCAFT00000103048.1 UniProtKB/TrEMBL
  ENSCAFT00030020766.1 UniProtKB/TrEMBL
  ENSCAFT00030020827.1 UniProtKB/TrEMBL
  ENSCAFT00030020904.1 UniProtKB/TrEMBL
  ENSCAFT00845031882 ENTREZGENE
  ENSCAFT00845031882.1 UniProtKB/TrEMBL
  ENSCAFT00845032026.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  DGK UniProtKB/TrEMBL
  Diacylglycerol_kin_accessory UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
KEGG Report cfa:491102 UniProtKB/TrEMBL
NCBI Gene DGKE ENTREZGENE
PANTHER DIACYLGLYCEROL KINASE EPSILON UniProtKB/TrEMBL
  PTHR11255 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  DAGK_acc UniProtKB/TrEMBL
  DAGK_cat UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART DAGKa UniProtKB/TrEMBL
  DAGKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8C0LPT1 ENTREZGENE
  A0A8C0MX95 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N008_CANLF UniProtKB/TrEMBL
  A0A8C0NAM8_CANLF UniProtKB/TrEMBL
  A0A8I3PA16 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S093 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PIT5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39918 ENTREZGENE