DKK4 (dickkopf WNT signaling pathway inhibitor 4) - Rat Genome Database

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Pathways
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Gene: DKK4 (dickkopf WNT signaling pathway inhibitor 4) Canis lupus familiaris
Analyze
Symbol: DKK4
Name: dickkopf WNT signaling pathway inhibitor 4
RGD ID: 12139180
Description: ENCODES a protein that exhibits co-receptor binding (inferred); receptor antagonist activity (inferred); INVOLVED IN negative regulation of hair follicle placode formation (ortholog); Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); IMMUNODEFICIENCY 15 (ortholog); immunodeficiency 15B (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dickkopf homolog 4; dickkopf-related protein 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,302,124 - 23,304,824 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,302,320 - 23,304,834 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,806,606 - 23,809,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,050,668 - 25,053,758 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,050,610 - 25,053,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,421,837 - 23,424,927 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,984,745 - 23,987,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,035,535 - 24,038,626 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DKK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,302,124 - 23,304,824 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,302,320 - 23,304,834 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,806,606 - 23,809,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,050,668 - 25,053,758 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,050,610 - 25,053,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,421,837 - 23,424,927 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,984,745 - 23,987,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,035,535 - 24,038,626 (+)NCBIUU_Cfam_GSD_1.0
DKK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,374,063 - 42,391,322 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,374,063 - 42,377,229 (-)EnsemblGRCh38hg38GRCh38
GRCh37842,231,581 - 42,234,747 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,350,743 - 42,353,831 (-)NCBINCBI36Build 36hg18NCBI36
Build 34842,350,743 - 42,353,830NCBI
Celera841,176,301 - 41,179,389 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,754,805 - 40,757,893 (-)NCBIHuRef
CHM1_1842,278,494 - 42,281,582 (-)NCBICHM1_1
T2T-CHM13v2.0842,644,359 - 42,661,636 (-)NCBIT2T-CHM13v2.0
Dkk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,113,701 - 23,117,563 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,114,059 - 23,117,563 (+)EnsemblGRCm39 Ensembl
GRCm38822,623,685 - 22,628,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,624,043 - 22,627,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,734,515 - 23,738,019 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,089,588 - 24,093,092 (+)NCBIMGSCv36mm8
Celera824,114,227 - 24,117,730 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Dkk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,105,679 - 76,109,044 (-)NCBIGRCr8
mRatBN7.21669,403,215 - 69,406,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,402,989 - 69,406,580 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,676,916 - 74,680,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,108,488 - 78,111,869 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,357,687 - 73,361,068 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,260,551 - 74,264,142 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,260,551 - 74,264,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,893,385 - 73,896,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,888,290 - 73,891,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1667,295,927 - 67,299,518 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
DKK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,824,615 - 60,846,740 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,541,571 - 36,563,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,618,173 - 41,638,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,062,711 - 39,082,575 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,062,711 - 39,082,575 (-)Ensemblpanpan1.1panPan2
Dkk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,362,345 - 46,366,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785319,494 - 323,055 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936785319,494 - 323,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,390,206 - 11,394,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,389,551 - 11,394,754 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21712,989,140 - 12,992,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DKK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,370,299 - 40,386,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,370,336 - 40,373,264 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,409,996 - 1,414,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780880,285 - 883,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624780873,669 - 884,091 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DKK4
25 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 13 3 5 6 12 4 10
Below cutoff 4 5 9 6 3 6 1 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008879   ⟹   ENSCAFP00000008237
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1623,302,320 - 23,304,834 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010755   ⟹   ENSCAFP00845008392
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1625,050,610 - 25,053,352 (+)Ensembl
RefSeq Acc Id: XM_038497486   ⟹   XP_038353414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11623,421,837 - 23,424,927 (+)NCBI
RefSeq Acc Id: XM_038559935   ⟹   XP_038415863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01624,035,535 - 24,038,626 (+)NCBI
RefSeq Acc Id: XM_038623972   ⟹   XP_038479900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01623,984,745 - 23,987,836 (+)NCBI
RefSeq Acc Id: XM_038689731   ⟹   XP_038545659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01625,050,668 - 25,053,758 (+)NCBI
RefSeq Acc Id: XM_843820   ⟹   XP_848913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11623,302,124 - 23,304,824 (+)NCBI
Dog10K_Boxer_Tasha1623,806,606 - 23,809,696 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_848913   ⟸   XM_843820
- UniProtKB: A0A8C0QAI1 (UniProtKB/TrEMBL),   A0A8I3MXR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000008237   ⟸   ENSCAFT00000008879
RefSeq Acc Id: XP_038353414   ⟸   XM_038497486
RefSeq Acc Id: XP_038479900   ⟸   XM_038623972
RefSeq Acc Id: XP_038545659   ⟸   XM_038689731
- UniProtKB: A0A8C0QAI1 (UniProtKB/TrEMBL),   A0A8I3MXR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415863   ⟸   XM_038559935
- UniProtKB: A0A8C0QAI1 (UniProtKB/TrEMBL),   A0A8I3MXR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845008392   ⟸   ENSCAFT00845010755
Protein Domains
Dickkopf N-terminal cysteine-rich   Dickkopf-related protein 1/2/4 C-terminal subdomain


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005508 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030020682 UniProtKB/TrEMBL
  ENSCAFG00040004970 UniProtKB/TrEMBL
  ENSCAFG00845006074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008879.3 UniProtKB/TrEMBL
  ENSCAFT00030037971.1 UniProtKB/TrEMBL
  ENSCAFT00040009371.1 UniProtKB/TrEMBL
  ENSCAFT00845010755 ENTREZGENE
  ENSCAFT00845010755.1 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom1 UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom2 UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk4_Cys2 UniProtKB/TrEMBL
NCBI Gene DKK4 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 4 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom1 UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom2 UniProtKB/TrEMBL
UniProt A0A8C0QAI1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MXR8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39972 ENTREZGENE