LPCAT4 (lysophosphatidylcholine acyltransferase 4) - Rat Genome Database

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Gene: LPCAT4 (lysophosphatidylcholine acyltransferase 4) Canis lupus familiaris
Analyze
Symbol: LPCAT4
Name: lysophosphatidylcholine acyltransferase 4
RGD ID: 12138923
Description: ENCODES a protein that exhibits 1-acylglycerophosphoethanolamine O-acyltransferase activity (ortholog); 1-acylglycerophosphoserine O-acyltransferase activity (ortholog); 1-alkenylglycerophosphoethanolamine O-acyltransferase activity (ortholog); INVOLVED IN phosphatidylethanolamine acyl-chain remodeling (ortholog); phosphatidylserine acyl-chain remodeling (ortholog); phospholipid metabolic process (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); AGPAT7; lysophospholipid acyltransferase LPCAT4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.130746,053 - 754,691 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30743,407 - 754,409 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha30791,499 - 798,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.030843,318 - 850,480 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.130791,724 - 798,884 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.030890,598 - 898,021 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0301,018,219 - 1,025,448 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LPCAT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.130746,053 - 754,691 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30743,407 - 754,409 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha30791,499 - 798,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.030843,318 - 850,480 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.130791,724 - 798,884 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.030890,598 - 898,021 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0301,018,219 - 1,025,448 (+)NCBIUU_Cfam_GSD_1.0
LPCAT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381534,358,633 - 34,367,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1534,358,633 - 34,367,196 (-)EnsemblGRCh38hg38GRCh38
GRCh371534,650,834 - 34,659,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,438,381 - 32,446,687 (-)NCBINCBI36Build 36hg18NCBI36
Celera1511,456,123 - 11,464,429 (-)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1511,516,634 - 11,524,938 (-)NCBIHuRef
CHM1_11534,769,140 - 34,777,446 (-)NCBICHM1_1
T2T-CHM13v2.01532,159,092 - 32,167,666 (-)NCBIT2T-CHM13v2.0
Lpcat4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392112,070,186 - 112,077,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2112,069,813 - 112,077,456 (+)EnsemblGRCm39 Ensembl
GRCm382112,239,841 - 112,247,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2112,239,468 - 112,247,111 (+)EnsemblGRCm38mm10GRCm38
MGSCv372112,079,998 - 112,087,268 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362112,040,680 - 112,047,950 (+)NCBIMGSCv36mm8
Celera2113,397,229 - 113,404,538 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.96NCBI
Lpcat4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83119,499,128 - 119,507,275 (+)NCBIGRCr8
mRatBN7.2399,044,729 - 99,052,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,044,729 - 99,052,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3102,672,578 - 102,680,717 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03111,271,570 - 111,279,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03108,967,183 - 108,975,331 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,725,762 - 103,733,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,726,238 - 103,733,354 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03110,320,562 - 110,328,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4398,083,263 - 98,091,300 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1397,980,063 - 97,987,458 (+)NCBI
Celera398,030,606 - 98,038,752 (+)NCBICelera
Cytogenetic Map3q35NCBI
Lpcat4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955416249,903 - 257,434 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955416251,057 - 257,379 (+)NCBIChiLan1.0ChiLan1.0
LPCAT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21623,143,073 - 23,151,401 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11527,864,869 - 27,873,082 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01512,869,782 - 12,878,350 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11531,704,297 - 31,712,779 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,704,297 - 31,712,779 (-)Ensemblpanpan1.1panPan2
Lpcat4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864079,299,901 - 79,308,708 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366732,840,099 - 2,851,240 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366732,843,798 - 2,851,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPCAT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl780,141,203 - 80,149,077 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1780,140,969 - 80,155,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2786,137,999 - 86,146,300 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LPCAT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,420,011 - 48,546,667 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,538,892 - 48,548,648 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604892,361,108 - 92,368,989 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpcat4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,136,094 - 4,147,738 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,140,274 - 4,147,810 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LPCAT4
96 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 6 12 10 6
Low 5 6 6 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012485   ⟹   ENSCAFP00000011566
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl30748,055 - 754,409 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000039108   ⟹   ENSCAFP00000055595
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl30743,407 - 745,531 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077776   ⟹   ENSCAFP00000049035
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl30747,407 - 754,409 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083508   ⟹   ENSCAFP00000059667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl30746,476 - 754,409 (+)Ensembl
RefSeq Acc Id: XM_038441818   ⟹   XP_038297746
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.030843,318 - 850,480 (+)NCBI
RefSeq Acc Id: XM_038461326   ⟹   XP_038317254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha30791,499 - 798,654 (+)NCBI
RefSeq Acc Id: XM_038516302   ⟹   XP_038372230
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.130791,724 - 798,884 (+)NCBI
RefSeq Acc Id: XM_038579898   ⟹   XP_038435826
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0301,018,219 - 1,025,448 (+)NCBI
RefSeq Acc Id: XM_038644152   ⟹   XP_038500080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.030890,598 - 898,021 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000055595   ⟸   ENSCAFT00000039108
RefSeq Acc Id: ENSCAFP00000049035   ⟸   ENSCAFT00000077776
RefSeq Acc Id: ENSCAFP00000059667   ⟸   ENSCAFT00000083508
RefSeq Acc Id: ENSCAFP00000011566   ⟸   ENSCAFT00000012485
RefSeq Acc Id: XP_038372230   ⟸   XM_038516302
RefSeq Acc Id: XP_038500080   ⟸   XM_038644152
RefSeq Acc Id: XP_038297746   ⟸   XM_038441818
- UniProtKB: A0A8C0PAC5 (UniProtKB/TrEMBL),   A0A8I3P6F8 (UniProtKB/TrEMBL),   A0A8C0TJ29 (UniProtKB/TrEMBL),   A0A8I3PBJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317254   ⟸   XM_038461326
- UniProtKB: A0A8C0PAC5 (UniProtKB/TrEMBL),   A0A8I3P6F8 (UniProtKB/TrEMBL),   A0A8C0TJ29 (UniProtKB/TrEMBL),   A0A8I3PBJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435826   ⟸   XM_038579898
- UniProtKB: A0A8C0PAC5 (UniProtKB/TrEMBL),   A0A8C0TJ29 (UniProtKB/TrEMBL),   A0A8I3P6F8 (UniProtKB/TrEMBL),   A0A8I3PBJ7 (UniProtKB/TrEMBL)
Protein Domains
Phospholipid/glycerol acyltransferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007814 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023216 UniProtKB/TrEMBL
  ENSCAFG00040023425 UniProtKB/TrEMBL
  ENSCAFG00845018434 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012485.5 UniProtKB/TrEMBL
  ENSCAFT00000083508.2 UniProtKB/TrEMBL
  ENSCAFT00030042780.1 UniProtKB/TrEMBL
  ENSCAFT00040043536.1 UniProtKB/TrEMBL
  ENSCAFT00040043557.1 UniProtKB/TrEMBL
  ENSCAFT00040043579.1 UniProtKB/TrEMBL
  ENSCAFT00845032600 ENTREZGENE
  ENSCAFT00845032600.1 UniProtKB/TrEMBL
  ENSCAFT00845032668.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro LPCAT1-like UniProtKB/TrEMBL
  Plipid/glycerol_acylTrfase UniProtKB/TrEMBL
NCBI Gene LPCAT4 ENTREZGENE
PANTHER LYSOPHOSPHOLIPID ACYLTRANSFERASE LPCAT4 UniProtKB/TrEMBL
  PHOSPHOLIPID ACYLTRANSFERASE UniProtKB/TrEMBL
Pfam Acyltransferase UniProtKB/TrEMBL
SMART PlsC UniProtKB/TrEMBL
Superfamily-SCOP Glycerol-3-phosphate (1)-acyltransferase UniProtKB/TrEMBL
UniProt A0A8C0PAC5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TJ29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TN82_CANLF UniProtKB/TrEMBL
  A0A8I3P6F8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PBJ7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54323 ENTREZGENE