CYP26A1 (cytochrome P450 family 26 subfamily A member 1) - Rat Genome Database

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Gene: CYP26A1 (cytochrome P450 family 26 subfamily A member 1) Canis lupus familiaris
Analyze
Symbol: CYP26A1
Name: cytochrome P450 family 26 subfamily A member 1
RGD ID: 12137992
Description: ENCODES a protein that exhibits all-trans retinoic acid 18-hydroxylase activity (inferred); heme binding (inferred); iron ion binding (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cellular response to retinoic acid (ortholog); central nervous system development (ortholog); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH actinic keratosis (ortholog); adenocarcinoma (ortholog); Barrett's adenocarcinoma (ortholog); INTERACTS WITH all-trans-retinoic acid
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome P450 26A1; cytochrome P450, family 26, subfamily A, polypeptide 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,423,955 - 7,432,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,428,772 - 7,432,370 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,605,185 - 7,608,930 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,688,620 - 7,692,365 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,688,780 - 7,692,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,408,839 - 7,412,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,446,115 - 7,449,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,607,985 - 7,611,730 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP26A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,423,955 - 7,432,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,428,772 - 7,432,370 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,605,185 - 7,608,930 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,688,620 - 7,692,365 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,688,780 - 7,692,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,408,839 - 7,412,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,446,115 - 7,449,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,607,985 - 7,611,730 (+)NCBIUU_Cfam_GSD_1.0
CYP26A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381093,073,475 - 93,077,885 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1093,073,475 - 93,077,885 (+)EnsemblGRCh38hg38GRCh38
GRCh371094,833,232 - 94,837,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,823,222 - 94,827,631 (+)NCBINCBI36Build 36hg18NCBI36
Build 341094,823,221 - 94,827,631NCBI
Celera1088,574,439 - 88,578,848 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,460,761 - 88,465,170 (+)NCBIHuRef
CHM1_11095,115,931 - 95,120,340 (+)NCBICHM1_1
T2T-CHM13v2.01093,953,370 - 93,957,780 (+)NCBIT2T-CHM13v2.0
Cyp26a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,686,186 - 37,689,984 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,686,246 - 37,689,984 (+)EnsemblGRCm39 Ensembl
GRCm381937,697,738 - 37,701,536 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,697,798 - 37,701,536 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,772,298 - 37,776,026 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,762,998 - 37,766,680 (+)NCBIMGSCv36mm8
Celera1938,484,789 - 38,488,516 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.36NCBI
Cyp26a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,883,822 - 244,887,657 (+)NCBIGRCr8
mRatBN7.21235,471,368 - 235,475,204 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,471,298 - 235,475,204 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,856,469 - 243,860,304 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,788,639 - 250,792,474 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,626,842 - 243,630,677 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,382,861 - 256,386,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,382,791 - 256,386,729 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,865,285 - 263,869,103 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,945,472 - 241,949,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,135,064 - 242,138,791 (-)NCBI
Celera1232,563,995 - 232,567,749 (+)NCBICelera
Cytogenetic Map1q53NCBI
CYP26A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28105,109,727 - 105,113,815 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110105,101,325 - 105,119,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,817,623 - 89,822,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11093,330,460 - 93,334,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,330,460 - 93,334,105 (+)Ensemblpanpan1.1panPan2
LOC101977861
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,177,867 - 40,181,785 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,809,992 - 1,814,074 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366011,810,572 - 1,815,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP26A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,563,195 - 104,567,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114104,561,394 - 104,567,099 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,201,978 - 114,205,507 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216270
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1986,310,142 - 86,328,622 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,325,401 - 86,328,775 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604847,091,899 - 47,095,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101699044
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247374,325,755 - 4,329,758 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247374,324,964 - 4,329,488 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CYP26A1
104 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 10 6 6 4
Below cutoff 5 12 5 6 8 7 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012129   ⟹   ENSCAFP00000011244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl287,428,772 - 7,432,370 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032510   ⟹   ENSCAFP00845025422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,688,780 - 7,692,376 (+)Ensembl
RefSeq Acc Id: XM_038439946   ⟹   XP_038295874
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,688,620 - 7,692,365 (+)NCBI
RefSeq Acc Id: XM_038514559   ⟹   XP_038370487
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1287,408,839 - 7,412,573 (+)NCBI
RefSeq Acc Id: XM_038577946   ⟹   XP_038433874
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0287,607,985 - 7,611,730 (+)NCBI
RefSeq Acc Id: XM_038642370   ⟹   XP_038498298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0287,446,115 - 7,449,848 (+)NCBI
RefSeq Acc Id: XM_844281   ⟹   XP_849374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,423,955 - 7,432,359 (+)NCBI
Dog10K_Boxer_Tasha287,605,185 - 7,608,930 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_849374   ⟸   XM_844281
- UniProtKB: A0A8C0QU96 (UniProtKB/TrEMBL),   A0A8C0Z3N5 (UniProtKB/TrEMBL),   A0A8I3P076 (UniProtKB/TrEMBL),   A0A8C0N338 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011244   ⟸   ENSCAFT00000012129
RefSeq Acc Id: XP_038370487   ⟸   XM_038514559
RefSeq Acc Id: XP_038498298   ⟸   XM_038642370
RefSeq Acc Id: XP_038295874   ⟸   XM_038439946
- UniProtKB: A0A8C0QU96 (UniProtKB/TrEMBL),   A0A8C0Z3N5 (UniProtKB/TrEMBL),   A0A8I3P076 (UniProtKB/TrEMBL),   A0A8C0N338 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433874   ⟸   XM_038577946
- UniProtKB: A0A8C0N338 (UniProtKB/TrEMBL),   A0A8C0QU96 (UniProtKB/TrEMBL),   A0A8C0Z3N5 (UniProtKB/TrEMBL),   A0A8I3P076 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845025422   ⟸   ENSCAFT00845032510

Promoters
RGD ID:13688267
Promoter ID:EPDNEW_C6335
Type:initiation region
Name:CYP26A1_1
Description:cytochrome P450 family 26 subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,428,730 - 7,428,790EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007574 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012944 UniProtKB/TrEMBL
  ENSCAFG00040021337 UniProtKB/TrEMBL
  ENSCAFG00845018365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012129.5 UniProtKB/TrEMBL
  ENSCAFT00030023954.1 UniProtKB/TrEMBL
  ENSCAFT00040039620.1 UniProtKB/TrEMBL
  ENSCAFT00845032510 ENTREZGENE
  ENSCAFT00845032510.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report cfa:486804 UniProtKB/TrEMBL
NCBI Gene CYP26A1 ENTREZGENE
PANTHER CYTOCHROME P450 26 UniProtKB/TrEMBL
  CYTOCHROME P450 26A1 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C0N338 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QU96 ENTREZGENE
  A0A8C0Z3N5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P076 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:50337 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYP26A1  cytochrome P450 family 26 subfamily A member 1    cytochrome P450, family 26, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED