TLR7 (toll like receptor 7) - Rat Genome Database

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Gene: TLR7 (toll like receptor 7) Canis lupus familiaris
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Symbol: TLR7
Name: toll like receptor 7
RGD ID: 12126695
Description: ENCODES a protein that exhibits double-stranded RNA binding (ortholog); single-stranded RNA binding (ortholog); siRNA binding (ortholog); INVOLVED IN defense response to virus (ortholog); positive regulation of interferon-alpha production (ortholog); positive regulation of interferon-beta production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH allergic contact dermatitis (ortholog); anogenital venereal wart (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); early phagosome (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll-like receptor 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X9,331,243 - 9,360,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX9,314,815 - 9,359,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX9,290,888 - 9,316,297 (+)NCBI
ROS_Cfam_1.0X9,283,446 - 9,312,699 (+)NCBI
ROS_Cfam_1.0 EnsemblX9,285,506 - 9,311,834 (+)Ensembl
UMICH_Zoey_3.1X9,270,957 - 9,296,384 (+)NCBI
UNSW_CanFamBas_1.0X9,310,224 - 9,335,853 (+)NCBI
UU_Cfam_GSD_1.0X9,302,542 - 9,328,038 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17913244   PMID:19568743  


Genomics

Comparative Map Data
TLR7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X9,331,243 - 9,360,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX9,314,815 - 9,359,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX9,290,888 - 9,316,297 (+)NCBI
ROS_Cfam_1.0X9,283,446 - 9,312,699 (+)NCBI
ROS_Cfam_1.0 EnsemblX9,285,506 - 9,311,834 (+)Ensembl
UMICH_Zoey_3.1X9,270,957 - 9,296,384 (+)NCBI
UNSW_CanFamBas_1.0X9,310,224 - 9,335,853 (+)NCBI
UU_Cfam_GSD_1.0X9,302,542 - 9,328,038 (+)NCBI
TLR7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X12,867,072 - 12,890,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX12,867,072 - 12,890,361 (+)EnsemblGRCh38hg38GRCh38
GRCh37X12,885,191 - 12,908,480 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,795,123 - 12,818,401 (+)NCBINCBI36hg18NCBI36
Build 34X12,644,862 - 12,666,567NCBI
CeleraX16,999,208 - 17,022,486 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX10,651,692 - 10,675,129 (+)NCBIHuRef
CHM1_1X12,915,641 - 12,938,921 (+)NCBICHM1_1
T2T-CHM13v2.0X12,448,550 - 12,471,838 (+)NCBI
Tlr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X166,086,376 - 166,113,570 (-)NCBIGRCm39mm39
GRCm39 EnsemblX166,087,925 - 166,113,554 (-)Ensembl
GRCm38X167,303,380 - 167,330,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,304,929 - 167,330,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,742,863 - 163,768,460 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X162,649,036 - 162,674,633 (-)NCBImm8
CeleraX150,452,330 - 150,504,044 (-)NCBICelera
Cytogenetic MapXF5NCBI
Tlr7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X27,027,380 - 27,054,309 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX27,027,425 - 27,054,754 (+)Ensembl
Rnor_6.0X28,486,836 - 28,513,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,486,869 - 28,512,957 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,882,968 - 28,908,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X47,330,737 - 47,356,841 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX27,439,445 - 27,465,491 (+)NCBICelera
Cytogenetic MapXq13NCBI
Tlr7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544424,850 - 443,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955544424,897 - 443,562 (-)NCBIChiLan1.0ChiLan1.0
TLR7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X12,768,698 - 12,790,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX12,767,981 - 12,790,517 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X5,479,247 - 5,504,810 (+)NCBIMhudiblu_PPA_v0panPan3
Tlr7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,593,498 - 2,611,939 (+)NCBI
SpeTri2.0NW_0049364702,593,544 - 2,610,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,348,520 - 11,372,132 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605613,140,418 - 13,165,724 (+)NCBIVero_WHO_p1.0
Tlr7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248821,375,216 - 1,379,705 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 15 6 6 12 8 9 4
Below cutoff 2 5 7 6 6 6 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018561   ⟹   ENSCAFP00000017193
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX9,333,576 - 9,359,603 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093895   ⟹   ENSCAFP00000043898
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX9,314,815 - 9,359,603 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049944   ⟹   ENSCAFP00845039166
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX9,285,506 - 9,311,834 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049963   ⟹   ENSCAFP00845039181
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX9,285,779 - 9,311,834 (+)Ensembl
RefSeq Acc Id: NM_001048124   ⟹   NP_001041589
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X9,334,187 - 9,359,594 (+)NCBI
Dog10K_Boxer_TashaX9,290,888 - 9,316,297 (+)NCBI
ROS_Cfam_1.0X9,286,390 - 9,311,825 (+)NCBI
UMICH_Zoey_3.1X9,270,957 - 9,296,384 (+)NCBI
UNSW_CanFamBas_1.0X9,310,224 - 9,335,853 (+)NCBI
UU_Cfam_GSD_1.0X9,302,542 - 9,328,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038448853   ⟹   XP_038304781
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X9,283,598 - 9,312,699 (+)NCBI
RefSeq Acc Id: XR_005309014
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X9,283,446 - 9,286,307 (+)NCBI
RefSeq Acc Id: XR_005309015
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X9,283,446 - 9,286,304 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001041589 (Get FASTA)   NCBI Sequence Viewer  
  XP_038304781 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC69204 (Get FASTA)   NCBI Sequence Viewer  
  BAE79271 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001041589   ⟸   NM_001048124
- UniProtKB: Q2L4T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000043898   ⟸   ENSCAFT00000093895
RefSeq Acc Id: ENSCAFP00000017193   ⟸   ENSCAFT00000018561
RefSeq Acc Id: XP_038304781   ⟸   XM_038448853
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845039166   ⟸   ENSCAFT00845049944
RefSeq Acc Id: ENSCAFP00845039181   ⟸   ENSCAFT00845049963
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011698 Ensembl
  ENSCAFG00040010785 UniProtKB/TrEMBL
  ENSCAFG00845028303 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00040017293 UniProtKB/TrEMBL
  ENSCAFP00040017300 UniProtKB/TrEMBL
  ENSCAFP00845039166 ENTREZGENE
  ENSCAFP00845039166.1 UniProtKB/TrEMBL
  ENSCAFP00845039181.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00040019934 UniProtKB/TrEMBL
  ENSCAFT00040019945 UniProtKB/TrEMBL
  ENSCAFT00845049944 ENTREZGENE
  ENSCAFT00845049944.1 UniProtKB/TrEMBL
  ENSCAFT00845049963.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_12 UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  TLR7 UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:491743 UniProtKB/TrEMBL
NCBI Gene TLR7 ENTREZGENE
PANTHER PTHR47410:SF2 UniProtKB/TrEMBL
Pfam LRR_12 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniProt A0A8C0S8I8_CANLF UniProtKB/TrEMBL
  A0A8C0S8P6_CANLF UniProtKB/TrEMBL
  A0A8I3PXA8_CANLF UniProtKB/TrEMBL
  A0A8I3SBE6_CANLF UniProtKB/TrEMBL
  A1XC23_CANLF UniProtKB/TrEMBL
  Q2L4T3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F6PLB9 UniProtKB/TrEMBL
VGNC ID VGNC:54607 ENTREZGENE