EED (embryonic ectoderm development) - Rat Genome Database

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Gene: EED (embryonic ectoderm development) Canis lupus familiaris
Analyze
Symbol: EED (Ensembl: HIKESHI)
Name: embryonic ectoderm development
RGD ID: 12126203
Description: ENCODES a protein that exhibits chromatin binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); facultative heterochromatin formation (ortholog); genomic imprinting (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Cohen-Gibson Syndrome (ortholog); exudative vitreoretinopathy 1 (ortholog); FOUND IN chromatin silencing complex (ortholog); nucleus (ortholog); pronucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: polycomb protein EED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12113,260,062 - 13,289,511 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2113,260,002 - 13,289,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2113,125,575 - 13,155,433 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02113,442,739 - 13,472,602 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12113,228,555 - 13,258,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02113,300,989 - 13,331,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02113,357,756 - 13,387,545 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EED
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12113,260,062 - 13,289,511 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2113,260,002 - 13,289,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2113,125,575 - 13,155,433 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02113,442,739 - 13,472,602 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12113,228,555 - 13,258,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02113,300,989 - 13,331,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02113,357,756 - 13,387,545 (-)NCBIUU_Cfam_GSD_1.0
EED
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,244,753 - 86,287,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,201,212 - 86,278,813 (+)EnsemblGRCh38hg38GRCh38
GRCh371185,955,795 - 85,989,852 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,633,463 - 85,667,429 (+)NCBINCBI36Build 36hg18NCBI36
Build 341185,633,462 - 85,667,426NCBI
Celera1183,265,529 - 83,300,439 (+)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,243,000 - 82,278,147 (+)NCBIHuRef
CHM1_11185,841,580 - 85,875,590 (+)NCBICHM1_1
T2T-CHM13v2.01186,186,227 - 86,228,460 (+)NCBIT2T-CHM13v2.0
Eed
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,603,862 - 89,630,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,603,862 - 89,630,191 (-)EnsemblGRCm39 Ensembl
GRCm38789,954,654 - 89,980,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,954,654 - 89,980,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv37797,103,164 - 97,129,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36789,829,868 - 89,857,005 (-)NCBIMGSCv36mm8
Celera787,275,683 - 87,302,613 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map750.42NCBI
Eed
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81153,280,419 - 153,307,537 (-)NCBIGRCr8
mRatBN7.21143,867,875 - 143,895,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,867,875 - 143,894,974 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,808,615 - 151,835,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,985,009 - 159,012,094 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,858,916 - 151,886,001 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,189,252 - 154,216,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,189,260 - 154,216,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,493,753 - 160,520,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,563,961 - 146,591,042 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,642,345 - 146,669,450 (-)NCBI
Celera1142,108,258 - 142,135,298 (-)NCBICelera
Cytogenetic Map1q32NCBI
Eed
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,659,055 - 6,685,530 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,659,144 - 6,685,530 (-)NCBIChiLan1.0ChiLan1.0
EED
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,159,183 - 87,197,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,210,050 - 88,248,464 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,295,068 - 81,330,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,902,330 - 84,937,906 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,902,330 - 84,937,906 (+)Ensemblpanpan1.1panPan2
Eed
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,451,606 - 72,483,821 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,051,045 - 14,083,570 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649814,050,731 - 14,082,410 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EED
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,123,857 - 20,158,816 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,123,077 - 20,158,747 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,382,548 - 22,417,549 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EED
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1177,496,266 - 77,531,439 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl177,496,086 - 77,531,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604348,194,395 - 48,229,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eed
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,679,096 - 3,712,176 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248453,679,163 - 3,712,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EED
327 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 15 6 6 10 10 4
Low 5 7 6 6 6 2 8 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000007206   ⟹   ENSCAFP00000006672
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2113,260,002 - 13,289,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088460   ⟹   ENSCAFP00000059933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2113,260,002 - 13,289,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093511   ⟹   ENSCAFP00000064161
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2113,260,002 - 13,289,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012873   ⟹   ENSCAFP00845010032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012917   ⟹   ENSCAFP00845010068
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012970   ⟹   ENSCAFP00845010109
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013022   ⟹   ENSCAFP00845010147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013090   ⟹   ENSCAFP00845010188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2113,442,743 - 13,472,368 (-)Ensembl
RefSeq Acc Id: XM_005633392   ⟹   XP_005633449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12113,260,062 - 13,289,511 (-)NCBI
Dog10K_Boxer_Tasha2113,125,575 - 13,155,433 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038429840   ⟹   XP_038285768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02113,442,739 - 13,472,602 (-)NCBI
RefSeq Acc Id: XM_038429841   ⟹   XP_038285769
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02113,442,739 - 13,472,600 (-)NCBI
RefSeq Acc Id: XM_038505232   ⟹   XP_038361160
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12113,228,555 - 13,258,431 (-)NCBI
RefSeq Acc Id: XM_038505233   ⟹   XP_038361161
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12113,228,555 - 13,258,429 (-)NCBI
RefSeq Acc Id: XM_038568376   ⟹   XP_038424304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02113,357,756 - 13,387,545 (-)NCBI
RefSeq Acc Id: XM_038568377   ⟹   XP_038424305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02113,357,756 - 13,387,543 (-)NCBI
RefSeq Acc Id: XM_038632522   ⟹   XP_038488450
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02113,300,989 - 13,331,006 (-)NCBI
RefSeq Acc Id: XM_038632523   ⟹   XP_038488451
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02113,300,989 - 13,331,004 (-)NCBI
RefSeq Acc Id: XM_852657   ⟹   XP_857750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12113,260,062 - 13,289,511 (-)NCBI
Dog10K_Boxer_Tasha2113,125,575 - 13,155,431 (-)NCBI
Sequence:
RefSeq Acc Id: XP_857750   ⟸   XM_852657
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KWJ3 (UniProtKB/TrEMBL),   A0A8C0Z482 (UniProtKB/TrEMBL),   A0A8I3N812 (UniProtKB/TrEMBL),   A0A8P0TII9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005633449   ⟸   XM_005633392
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TGG9 (UniProtKB/TrEMBL),   A0A8I3N299 (UniProtKB/TrEMBL),   A0A8I3N812 (UniProtKB/TrEMBL),   A0A8P0TII9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000059933   ⟸   ENSCAFT00000088460
RefSeq Acc Id: ENSCAFP00000064161   ⟸   ENSCAFT00000093511
RefSeq Acc Id: ENSCAFP00000006672   ⟸   ENSCAFT00000007206
RefSeq Acc Id: XP_038361160   ⟸   XM_038505232
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038361161   ⟸   XM_038505233
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038488450   ⟸   XM_038632522
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488451   ⟸   XM_038632523
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038285768   ⟸   XM_038429840
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TGG9 (UniProtKB/TrEMBL),   A0A8I3N299 (UniProtKB/TrEMBL),   A0A8I3N812 (UniProtKB/TrEMBL),   A0A8P0TII9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038285769   ⟸   XM_038429841
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KWJ3 (UniProtKB/TrEMBL),   A0A8C0Z482 (UniProtKB/TrEMBL),   A0A8I3N812 (UniProtKB/TrEMBL),   A0A8P0TII9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038424304   ⟸   XM_038568376
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TGG9 (UniProtKB/TrEMBL),   A0A8I3N299 (UniProtKB/TrEMBL),   A0A8I3N812 (UniProtKB/TrEMBL),   A0A8P0TII9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038424305   ⟸   XM_038568377
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KWJ3 (UniProtKB/TrEMBL),   A0A8C0Z482 (UniProtKB/TrEMBL),   A0A8I3N812 (UniProtKB/TrEMBL),   A0A8P0TII9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010032   ⟸   ENSCAFT00845012873
RefSeq Acc Id: ENSCAFP00845010188   ⟸   ENSCAFT00845013090
RefSeq Acc Id: ENSCAFP00845010068   ⟸   ENSCAFT00845012917
RefSeq Acc Id: ENSCAFP00845010147   ⟸   ENSCAFT00845013022
RefSeq Acc Id: ENSCAFP00845010109   ⟸   ENSCAFT00845012970

Promoters
RGD ID:13687165
Promoter ID:EPDNEW_C5233
Type:multiple initiation site
Name:EED_1
Description:embryonic ectoderm development
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12113,289,245 - 13,289,305EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004471 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010279 UniProtKB/TrEMBL
  ENSCAFG00040021805 UniProtKB/TrEMBL
  ENSCAFG00845007205 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007206.5 UniProtKB/TrEMBL
  ENSCAFT00000088460.2 UniProtKB/TrEMBL
  ENSCAFT00000093511.2 UniProtKB/TrEMBL
  ENSCAFT00000096608.1 UniProtKB/TrEMBL
  ENSCAFT00000097502.1 UniProtKB/TrEMBL
  ENSCAFT00030019632.1 UniProtKB/TrEMBL
  ENSCAFT00030019703.1 UniProtKB/TrEMBL
  ENSCAFT00030019789.1 UniProtKB/TrEMBL
  ENSCAFT00040040984.1 UniProtKB/TrEMBL
  ENSCAFT00040041008.1 UniProtKB/TrEMBL
  ENSCAFT00040041075.1 UniProtKB/TrEMBL
  ENSCAFT00845012873 ENTREZGENE
  ENSCAFT00845012873.1 UniProtKB/TrEMBL
  ENSCAFT00845012917 ENTREZGENE
  ENSCAFT00845012917.1 UniProtKB/TrEMBL
  ENSCAFT00845012970.1 UniProtKB/TrEMBL
  ENSCAFT00845013022.1 UniProtKB/TrEMBL
  ENSCAFT00845013090.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:476779 UniProtKB/TrEMBL
NCBI Gene EED ENTREZGENE
PANTHER POLYCOMB PROTEIN UniProtKB/TrEMBL
  PTHR10253:SF5 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0KWJ3 ENTREZGENE
  A0A8C0TE33_CANLF UniProtKB/TrEMBL
  A0A8C0TGG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z482 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N299 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2D0_CANLF UniProtKB/TrEMBL
  A0A8I3N2P2_CANLF UniProtKB/TrEMBL
  A0A8I3N5R4_CANLF UniProtKB/TrEMBL
  A0A8I3N812 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SA27_CANLF UniProtKB/TrEMBL
  A0A8P0TBW3_CANLF UniProtKB/TrEMBL
  A0A8P0TII9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40206 ENTREZGENE