CIAO1 (cytosolic iron-sulfur assembly component 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CIAO1 (cytosolic iron-sulfur assembly component 1) Canis lupus familiaris
Analyze
Symbol: CIAO1
Name: cytosolic iron-sulfur assembly component 1
RGD ID: 12125284
Description: INVOLVED IN chromosome segregation (inferred); iron-sulfur cluster assembly (inferred); protein maturation by iron-sulfur cluster transfer (inferred); PARTICIPATES IN cytosolic iron-sulfur cluster protein assembly pathway; ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); schizophrenia (ortholog); FOUND IN CIA complex (inferred); cytoplasm (inferred); MMXD complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytosolic iron-sulfur protein assembly 1 homolog; probable cytosolic iron-sulfur protein assembly protein CIAO1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,507,136 - 34,512,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,508,662 - 34,512,486 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,277,047 - 34,282,512 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,278,219 - 35,283,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,278,225 - 35,283,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,407,476 - 34,412,941 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,476,119 - 34,481,585 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,682,825 - 34,688,404 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CIAO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,507,136 - 34,512,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,508,662 - 34,512,486 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,277,047 - 34,282,512 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,278,219 - 35,283,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,278,225 - 35,283,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,407,476 - 34,412,941 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,476,119 - 34,481,585 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,682,825 - 34,688,404 (-)NCBIUU_Cfam_GSD_1.0
CIAO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,266,225 - 96,274,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,266,159 - 96,274,173 (+)EnsemblGRCh38hg38GRCh38
GRCh37296,931,963 - 96,939,911 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,295,611 - 96,303,644 (+)NCBINCBI36Build 36hg18NCBI36
Build 34296,353,757 - 96,361,786NCBI
Celera291,373,072 - 91,381,105 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,893,381 - 90,901,414 (+)NCBIHuRef
CHM1_1296,936,239 - 96,944,254 (+)NCBICHM1_1
T2T-CHM13v2.0296,772,833 - 96,780,781 (+)NCBIT2T-CHM13v2.0
Ciao1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,082,858 - 127,089,736 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,082,858 - 127,089,736 (-)EnsemblGRCm39 Ensembl
GRCm382127,240,938 - 127,247,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,240,938 - 127,247,816 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,066,674 - 127,073,552 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,932,379 - 126,939,183 (-)NCBIMGSCv36mm8
Celera2128,480,303 - 128,487,188 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.86NCBI
Ciao1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,913,639 - 134,919,244 (-)NCBIGRCr8
mRatBN7.23114,458,671 - 114,465,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,458,655 - 114,467,009 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,351,884 - 118,357,408 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,947,428 - 126,952,952 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,607,808 - 124,613,332 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,671,778 - 119,677,324 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,671,779 - 119,678,092 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,196,996 - 126,202,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,740,676 - 114,746,203 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,646,248 - 114,651,776 (-)NCBI
Celera3113,300,999 - 113,306,382 (-)NCBICelera
Cytogenetic Map3q36NCBI
Ciao1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,822,582 - 3,828,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,822,606 - 3,828,563 (+)NCBIChiLan1.0ChiLan1.0
CIAO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,034,666 - 32,042,638 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,037,475 - 32,045,398 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,041,509 - 103,049,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,189,246 - 97,194,576 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A97,188,949 - 97,194,576 (+)Ensemblpanpan1.1panPan2
Ciao1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,106,283 - 83,111,710 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744359,258 - 363,585 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744359,234 - 364,649 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIAO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl346,960,881 - 46,966,635 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1346,960,880 - 46,967,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,102,770 - 49,108,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIAO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114685,378 - 690,752 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14685,321 - 690,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041168,111,923 - 168,117,714 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ciao1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,344,743 - 2,351,358 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,344,833 - 2,350,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CIAO1
87 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 2 16 6 6 12 10 6
Low 3 3 6 6 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010914   ⟹   ENSCAFP00000010114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1734,508,662 - 34,512,486 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845010865   ⟹   ENSCAFP00845008479
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1735,278,225 - 35,283,748 (-)Ensembl
RefSeq Acc Id: XM_038498816   ⟹   XP_038354744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11734,407,476 - 34,412,941 (-)NCBI
RefSeq Acc Id: XM_038561377   ⟹   XP_038417305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01734,682,825 - 34,688,404 (-)NCBI
RefSeq Acc Id: XM_038625431   ⟹   XP_038481359
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01734,476,119 - 34,481,585 (-)NCBI
RefSeq Acc Id: XM_038691358   ⟹   XP_038547286
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01735,278,219 - 35,283,798 (-)NCBI
RefSeq Acc Id: XM_532950   ⟹   XP_532950
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11734,507,136 - 34,512,566 (-)NCBI
Dog10K_Boxer_Tasha1734,277,047 - 34,282,512 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_532950   ⟸   XM_532950
- UniProtKB: A0A8C0N7E3 (UniProtKB/TrEMBL),   A0A8C0L6P4 (UniProtKB/TrEMBL),   A0A8I3MTM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010114   ⟸   ENSCAFT00000010914
RefSeq Acc Id: XP_038354744   ⟸   XM_038498816
RefSeq Acc Id: XP_038481359   ⟸   XM_038625431
RefSeq Acc Id: XP_038547286   ⟸   XM_038691358
- UniProtKB: A0A8C0N7E3 (UniProtKB/TrEMBL),   A0A8C0L6P4 (UniProtKB/TrEMBL),   A0A8I3MTM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038417305   ⟸   XM_038561377
- UniProtKB: A0A8C0L6P4 (UniProtKB/TrEMBL),   A0A8C0N7E3 (UniProtKB/TrEMBL),   A0A8I3MTM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845008479   ⟸   ENSCAFT00845010865

Promoters
RGD ID:13686242
Promoter ID:EPDNEW_C4309
Type:initiation region
Name:CIAO1_1
Description:cytosolic iron-sulfur assembly component 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11734,512,475 - 34,512,535EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006776 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012553 UniProtKB/TrEMBL
  ENSCAFG00040025733 UniProtKB/TrEMBL
  ENSCAFG00845006123 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010914.5 UniProtKB/TrEMBL
  ENSCAFT00030023237.1 UniProtKB/TrEMBL
  ENSCAFT00040048038.1 UniProtKB/TrEMBL
  ENSCAFT00845010865 ENTREZGENE
  ENSCAFT00845010865.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro CIAO1/Cia1 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:475743 UniProtKB/TrEMBL
NCBI Gene CIAO1 ENTREZGENE
PANTHER CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED UniProtKB/TrEMBL
  PTHR19920 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0L6P4 ENTREZGENE
  A0A8C0N7E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MTM5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39263 ENTREZGENE