CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7) - Rat Genome Database

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Gene: CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7) Canis lupus familiaris
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Symbol: CYP2A7
Name: cytochrome P450, family 2, subfamily A, polypeptide 7
RGD ID: 12124799
Description: ENCODES a protein that exhibits coumarin 7-hydroxylase activity (ortholog); enzyme binding (ortholog); heme binding (ortholog); INVOLVED IN coumarin catabolic process (ortholog); coumarin metabolic process (ortholog); steroid metabolic process (ortholog); PARTICIPATES IN caffeine pharmacokinetics pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH adenocarcinoma (ortholog); brain disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasmic microtubule (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CYP2A25; cytochrome P450 2A25
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,900,508 - 112,906,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,900,403 - 112,907,076 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,303,147 - 112,309,374 (+)NCBI
ROS_Cfam_1.01113,498,625 - 113,504,857 (+)NCBI
UMICH_Zoey_3.11113,058,524 - 113,064,755 (+)NCBI
UNSW_CanFamBas_1.01112,690,120 - 112,696,347 (+)NCBI
UU_Cfam_GSD_1.01113,684,433 - 113,690,643 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
CYP2A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,900,508 - 112,906,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,900,403 - 112,907,076 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,303,147 - 112,309,374 (+)NCBI
ROS_Cfam_1.01113,498,625 - 113,504,857 (+)NCBI
UMICH_Zoey_3.11113,058,524 - 113,064,755 (+)NCBI
UNSW_CanFamBas_1.01112,690,120 - 112,696,347 (+)NCBI
UU_Cfam_GSD_1.01113,684,433 - 113,690,643 (+)NCBI
CYP2A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1940,843,541 - 40,850,447 (-)EnsemblGRCh38hg38GRCh38
GRCh381940,843,541 - 40,850,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,349,446 - 41,356,352 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,041,284 - 46,048,180 (-)NCBINCBI36hg18NCBI36
Build 341946,041,283 - 46,048,180NCBI
Celera1938,149,869 - 38,156,776 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,782,698 - 37,789,605 (-)NCBIHuRef
CHM1_11941,349,113 - 41,356,113 (-)NCBICHM1_1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 1 6 4
Below cutoff 5 5 15 4 6 5 12 8 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008131   ⟹   ENSCAFP00000007531
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,900,403 - 112,907,076 (+)Ensembl
RefSeq Acc Id: NM_001048027   ⟹   NP_001041492
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,900,508 - 112,906,745 (+)NCBI
Dog10K_Boxer_Tasha1112,303,147 - 112,309,374 (+)NCBI
ROS_Cfam_1.01113,498,625 - 113,504,857 (+)NCBI
UMICH_Zoey_3.11113,058,524 - 113,064,755 (+)NCBI
UNSW_CanFamBas_1.01112,690,120 - 112,696,347 (+)NCBI
UU_Cfam_GSD_1.01113,684,433 - 113,690,643 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001041492 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB43281 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001041492   ⟸   NM_001048027
- UniProtKB: Q307K7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007531   ⟸   ENSCAFT00000008131

Promoters
RGD ID:13682289
Promoter ID:EPDNEW_C358
Type:single initiation site
Name:CYP2A7_1
Description:cytochrome P450, family 2, subfamily A, polypeptide 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,900,482 - 112,900,542EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 112900577 112900578 T A snv Australian Cattle dog (AC023), Australian Cattle dog (AC046), Australian Cattle dog (AC065), Australian Cattle dog (AC108), Alpine Dachsbracke (AD009), Alaskan Malamute (AM007), Australian Terrier (AR001), American Staffordshire Terrier (AS006), Berger Blanc Suisse (BB011), Border Collie (BC0480), Border Collie (BC272), Border Collie (BC273), Border Collie (BC485), Border Collie (BC518), Border Collie (BC555), Border Collie (BC597), Bearded Collie (BD016), Bearded Collie (BD036), Bearded Collie (BD052), Bearded Collie (BD085), Bearded Collie (BD089), Bearded Collie (BD091), Bearded Collie (BD093), Bearded Collie (BD098), Beagle (BE020), Bavarian Hound (BG064), Basset (BH003), Basenji (BJ002), Basenji (BJ004), Basenji (BJ005), Bullmastiff (BU002), Cairn Terrier (CE073), Chihuahua (CH019), Cavalier King Charles Spaniel (CK006), Cavalier King Charles Spaniel (CK023), Cocker Spaniel (CP003), Curly Coated Retriever (CR039), Chow Chow (CW011), Great Dane (DD116), Dachshund (DH0117), Dachshund (DH098), Dachshund (DH126), Doberman Pinscher (DO159), Doberman Pinscher (DO242), Doberman Pinscher (DO263), Chinese indigenous dogs (DQ1), Chinese indigenous dogs (DQ10), Chinese indigenous dogs (DQ2), Chinese indigenous dogs (DQ3), Chinese indigenous dogs (DQ4), Chinese indigenous dogs (DQ5), Chinese indigenous dogs (DQ6), Chinese indigenous dogs (DQ7), Chinese indigenous dogs (DQ8), Chinese indigenous dogs (DQ9), German Shepherd/Mixed breed (DS041), German Shepherd/Mixed breed (DS042), German Shepherd (DS043), German Shepherd (DS051), German Shepherd (DS053), German Shepherd (DS064), Elo (EL565), Entlebucher Sennenhund (EN091), Entlebucher Sennenhund (EN154), Entlebucher Sennenhund (EN221), Entlebucher Sennenhund (EN247), Entlebucher Sennenhund (EN261), Entlebucher Sennenhund (EN262), Entlebucher Sennenhund (EN263), Entlebucher Sennenhund (EN264), Eurasier (EU008), Eurasier (EU035), French Bulldog (FB046), French Bulldog (FB065), Golden Retriever (GR0855), Golden Retriever (GR0859), Golden Retriever (GR0860), Golden Retriever (GR0892), Golden Retriever (GR1078), German Shepherd (GS1), German Shepherd (GS10), German Spitz (GS104), German Shepherd (GS2), German Shepherd (GS3), German Shepherd (GS4), German Shepherd (GS5), German Shepherd (GS6), German Shepherd (GS7), German Shepherd (GS8), German Shepherd (GS9), German Wirehaired (GW004), Greyhound (GY432), Heideterrier (HT001), Hovawart (HW1706), Irish Terrier (IT0390), Irish Terrier (IT221), Jack Russell Terrier (JR0034), German Hunting Terrier (JT007), Jagdterrier (JT011), Kromfohrländer (KF042), Siberian Husky (KKH2684), Kunming Dog (KM1), Kunming Dog (KM10), Kunming Dog (KM2), Kunming Dog (KM3), Kunming Dog (KM4), Kunming Dog (KM5), Kunming Dog (KM6), Kunming Dog (KM7), Kunming Dog (KM9), Labrador Retriever (LA1869), Labrador Retriever (LA2382), Labrador Retriever (LA2443), Labrador Retriever (LA882), Labrador Retriever (LA900), Leonberger (LB111), Leonberger (LB1919), Chinese indigenous dogs (LJ1), Chinese indigenous dogs (LJ10), Chinese indigenous dogs (LJ2), Chinese indigenous dogs (LJ3), Chinese indigenous dogs (LJ4), Chinese indigenous dogs (LJ5), Chinese indigenous dogs (LJ6), Chinese indigenous dogs (LJ7), Chinese indigenous dogs (LJ8), Chinese indigenous dogs (LJ9), Landseer (LN048), Border Collie (LN47), Lagotto Romagnolo (LR1030), Lagotto Romagnolo (LR390), Lagotto Romagnolo (LR433), Lagotto Romagnolo (LR494), Lagotto Romagnolo (LR538), Lagotto Romagnolo (LR654), Lagotto Romagnolo (LR753), Malinois (MA008), Malinois (MA0163), Malinois (MA094), Malinois (MA142), Malinois (MA152), Malinois (MA324), Norwich Terrier (NW062), Norwich Terrier (NW152), Norwich Terrier (NW206), Norwich Terrier (NW255), Old English Sheepdog (OS001), Spanish Water Dog (PE002), Poodle (PL116), Rottweiler (RO2), Rhodesian Ridgeback (RR098), Rhodesian Ridgeback (RR123), Rhodesian Ridgeback (RR224), Sloughi (SG005), Sloughi (SG008), Greater Swiss Mountain Dog (SH008), Cavalier King Charles Spaniel (SID00101), Saluki (SL006), Great Lakes Wolf (SRS661486), Spanish Wolf (SRS661495), Yellowstone Wolf (SRS661496), Chinese Crested (SRS713815), Black Russian Terrier (SRS833812), Border Terrier (SRS932144), Alaskan Husky (SY001), Alaskan Husky (SY018), Siberian Husky (SY046), Airedale Terrier (TA001), Tibetan Mastiff (TM1), Tibetan Mastiff (TM10), Tibetan Mastiff (TM3), Tibetan Mastiff (TM4), Tibetan Mastiff (TM5), Tibetan Mastiff (TM6), Tibetan Mastiff (TM7), Tibetan Mastiff (TM8), Weimaraner (WE006), Weimaraner (WE008), Whippet (WH083), West Highland White Terrier (WW174), West Highland White Terrier (WW361), West Highland White Terrier (WW362), West Highland White Terrier (WW363), West Highland White Terrier (WW364), West Highland White Terrier (WW558), West Highland White Terrier (WW64), Chinese indigenous dogs (YJ1), Chinese indigenous dogs (YJ2), Chinese indigenous dogs (YJ3), Chinese indigenous dogs (YJ4), Chinese indigenous dogs (YJ5), Chinese indigenous dogs (YJ6), Chinese indigenous dogs (YJ7), Chinese indigenous dogs (YJ9), Yorkshire Terrier (YT003), Landseer (ZS14), Pomeranian (ZS14_2)
1 112900604 112900605 C T snv Lagotto Romagnolo (LR390), Lagotto Romagnolo (LR1030), French Bulldog (FB046), Doberman Pinscher (DO159)
1 112902018 112902019 G A snv Lagotto Romagnolo (LR433)
1 112905908 112905909 C A snv Basenji (BJ002), Basenji (BJ003), Basenji (BJ004), Basenji (BJ005), Basenji (BJ006), Miniature Bullterrier (BT007), Bullterrier (BT012), Great Dane (DD116), Dachshund (DH0117), Chinese indigenous dogs (DQ4), German Shepherd/Mixed breed (DS032), Eurasier (EU008), Hovawart (HW1706), Irish Terrier (IT0390), Kunming Dog (KM10), Kunming Dog (KM8), Leonberger (LB1919), Malinois (MA0163), Mixed Breed (MI016), Sloughi (SG005), Sloughi (SG008), Iranian Wolf (SRS661488), Portuguese Wolf (SRS661492), Yellowstone Wolf (SRS661496), Pembroke Welsh Corgi (SRS732551), Shetland Sheepdog (SRS932138), Standard Poodle (SRS932143), Shetland Sheepdog (SS004), Siberian Husky (SY046), Tibetan Mastiff (TM1), Tibetan Mastiff (TM2), Tibetan Mastiff (TM3), Tibetan Mastiff (TM9), Wolf (WO001_895), Wolf (WO002_732), Wolf (WO003_636), Basenji (BJ001), Border Collie (BC597), Border Collie (BC0480), Australian Shepherd (AU178), Australian Cattle dog (AC108), Alpine Dachsbracke (AD009)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031823 Ensembl
NCBI Gene CYP2A7 ENTREZGENE
UniProt Q307K7 ENTREZGENE