LTO1 (LTO1 maturation factor of ABCE1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: LTO1 (LTO1 maturation factor of ABCE1) Canis lupus familiaris
Analyze
Symbol: LTO1
Name: LTO1 maturation factor of ABCE1
RGD ID: 12124240
Description: INVOLVED IN protein maturation by [4Fe-4S] cluster transfer (ortholog); ribosomal large subunit biogenesis (ortholog); translational initiation (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); genetic disease (ortholog); intellectual disability (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LTO1, ABCE1 maturation factor; oral cancer overexpressed 1; oral cancer-overexpressed protein 1; ORAOV1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,482,212 - 48,490,678 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,481,955 - 48,490,691 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,092,162 - 47,100,619 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,159,378 - 49,167,844 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11848,606,017 - 48,614,464 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,192,327 - 48,200,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,938,336 - 48,946,799 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Genomics

Comparative Map Data
LTO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,482,212 - 48,490,678 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,481,955 - 48,490,691 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,092,162 - 47,100,619 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,159,378 - 49,167,844 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11848,606,017 - 48,614,464 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,192,327 - 48,200,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,938,336 - 48,946,799 (+)NCBIUU_Cfam_GSD_1.0
LTO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,665,563 - 69,675,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,653,076 - 69,675,416 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,480,331 - 69,490,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,189,512 - 69,199,346 (-)NCBINCBI36Build 36hg18NCBI36
Build 341169,189,514 - 69,199,346NCBI
Celera1166,777,361 - 66,787,192 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,772,815 - 65,782,647 (-)NCBIHuRef
CHM1_11169,363,332 - 69,373,166 (-)NCBICHM1_1
T2T-CHM13v2.01169,682,440 - 69,692,229 (-)NCBIT2T-CHM13v2.0
LTO1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,468,882 - 144,485,989 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,468,837 - 144,485,438 (+)EnsemblGRCm39 Ensembl
GRCm387144,915,100 - 144,930,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,915,100 - 144,931,701 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,101,099 - 152,107,042 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,724,584 - 144,730,527 (+)NCBIMGSCv36mm8
Celera7144,680,399 - 144,686,346 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.92NCBI
Lto1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,502,900 - 209,510,237 (+)NCBIGRCr8
mRatBN7.21200,074,247 - 200,080,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,074,253 - 200,088,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,455,415 - 208,462,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,541,679 - 215,548,382 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,215,886 - 208,222,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,075,995 - 218,082,700 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,076,116 - 218,080,824 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,940,388 - 224,952,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,342,480 - 205,349,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,495,985 - 205,500,860 (+)NCBI
Celera1197,632,313 - 197,639,016 (+)NCBICelera
Cytogenetic Map1q42NCBI
Lto1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,433,743 - 16,441,739 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,433,589 - 16,440,506 (+)NCBIChiLan1.0ChiLan1.0
LTO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2970,631,302 - 70,642,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,672,948 - 71,686,817 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,761,465 - 64,771,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,052,676 - 68,062,509 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,040,388 - 68,062,509 (-)Ensemblpanpan1.1panPan2
Lto1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,518,639 - 4,522,925 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599961,113 - 965,274 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936599961,060 - 965,274 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,607,600 - 3,615,616 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,607,605 - 3,615,621 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,095,064 - 2,103,080 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,888,769 - 4,900,379 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14,889,155 - 4,897,348 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,162,339 - 102,175,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lto1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,454,043 - 17,461,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,453,894 - 17,460,448 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LTO1
134 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 22 6 6 6 6 12 4 10 6
Low 1 5 6 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017021   ⟹   ENSCAFP00000015748
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1848,481,955 - 48,490,691 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000061909   ⟹   ENSCAFP00000057055
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1848,481,955 - 48,490,691 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067776   ⟹   ENSCAFP00000065032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1848,481,955 - 48,489,094 (+)Ensembl
RefSeq Acc Id: XM_005631376   ⟹   XP_005631433
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11848,482,212 - 48,488,763 (+)NCBI
Dog10K_Boxer_Tasha1847,092,162 - 47,098,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038424726   ⟹   XP_038280654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01849,159,378 - 49,167,844 (+)NCBI
RefSeq Acc Id: XM_038424727   ⟹   XP_038280655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01849,159,378 - 49,165,920 (+)NCBI
RefSeq Acc Id: XM_038500977   ⟹   XP_038356905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11848,606,017 - 48,614,464 (+)NCBI
RefSeq Acc Id: XM_038500978   ⟹   XP_038356906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11848,606,017 - 48,612,544 (+)NCBI
RefSeq Acc Id: XM_038563654   ⟹   XP_038419582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01848,938,336 - 48,946,799 (+)NCBI
RefSeq Acc Id: XM_038563655   ⟹   XP_038419583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01848,938,336 - 48,944,874 (+)NCBI
RefSeq Acc Id: XM_038627774   ⟹   XP_038483702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01848,192,327 - 48,200,772 (+)NCBI
RefSeq Acc Id: XM_038627776   ⟹   XP_038483704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01848,192,327 - 48,198,863 (+)NCBI
RefSeq Acc Id: XM_849426   ⟹   XP_854519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11848,482,220 - 48,490,678 (+)NCBI
Dog10K_Boxer_Tasha1847,092,162 - 47,100,619 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005631433   ⟸   XM_005631376
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_854519   ⟸   XM_849426
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NRM4 (UniProtKB/TrEMBL),   A0A8P0TQH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000065032   ⟸   ENSCAFT00000067776
RefSeq Acc Id: ENSCAFP00000057055   ⟸   ENSCAFT00000061909
RefSeq Acc Id: ENSCAFP00000015748   ⟸   ENSCAFT00000017021
RefSeq Acc Id: XP_038356905   ⟸   XM_038500977
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038356906   ⟸   XM_038500978
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483702   ⟸   XM_038627774
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038483704   ⟸   XM_038627776
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038280654   ⟸   XM_038424726
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NRM4 (UniProtKB/TrEMBL),   A0A8P0TQH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038280655   ⟸   XM_038424727
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038419582   ⟸   XM_038563654
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NRM4 (UniProtKB/TrEMBL),   A0A8P0TQH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419583   ⟸   XM_038563655
- Peptide Label: isoform X2
Protein Domains
Essential protein Yae1 N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010698 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024486 UniProtKB/TrEMBL
  ENSCAFG00845015244 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017021.5 UniProtKB/TrEMBL
  ENSCAFT00000061909.2 UniProtKB/TrEMBL
  ENSCAFT00000067776.2 UniProtKB/TrEMBL
  ENSCAFT00000102664.1 UniProtKB/TrEMBL
  ENSCAFT00000103927.1 UniProtKB/TrEMBL
  ENSCAFT00030045062.1 UniProtKB/TrEMBL
  ENSCAFT00030045077.1 UniProtKB/TrEMBL
  ENSCAFT00845027230.1 UniProtKB/TrEMBL
  ENSCAFT00845027251.1 UniProtKB/TrEMBL
  ENSCAFT00845027268.1 UniProtKB/TrEMBL
  ENSCAFT00845027288.1 UniProtKB/TrEMBL
  ENSCAFT00845027307.1 UniProtKB/TrEMBL
InterPro Essential_protein_Yae1_N UniProtKB/TrEMBL
NCBI Gene ORAOV1 ENTREZGENE
PANTHER GEO13458P1 UniProtKB/TrEMBL
  LTO1 MATURATION FACTOR OF ABCE1 UniProtKB/TrEMBL
  MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 UniProtKB/TrEMBL
  PROTEIN LTO1 HOMOLOG UniProtKB/TrEMBL
Pfam Yae1_N UniProtKB/TrEMBL
UniProt A0A8C0PAY2_CANLF UniProtKB/TrEMBL
  A0A8C0PF74_CANLF UniProtKB/TrEMBL
  A0A8I3NM42_CANLF UniProtKB/TrEMBL
  A0A8I3NRM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NW96_CANLF UniProtKB/TrEMBL
  A0A8I3NZU5_CANLF UniProtKB/TrEMBL
  A0A8I3RYR3_CANLF UniProtKB/TrEMBL
  A0A8P0TGG6_CANLF UniProtKB/TrEMBL
  A0A8P0TK27_CANLF UniProtKB/TrEMBL
  A0A8P0TQH9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0NCP8 UniProtKB/TrEMBL
  A0A8P0P6B3 UniProtKB/TrEMBL
VGNC ID VGNC:56091 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-26 LTO1  LTO1 maturation factor of ABCE1  LTO1  LTO1, ABCE1 maturation factor  Symbol and/or name change 5135510 APPROVED
2018-05-22 LTO1  LTO1, ABCE1 maturation factor  ORAOV1  oral cancer overexpressed 1  Symbol and/or name change 5135510 APPROVED