PMM2 (phosphomannomutase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PMM2 (phosphomannomutase 2) Canis lupus familiaris
Analyze
Symbol: PMM2
Name: phosphomannomutase 2
RGD ID: 12123359
Description: ENCODES a protein that exhibits isomerase activity (inferred); metal ion binding (inferred); phosphomannomutase activity (inferred); INVOLVED IN GDP-mannose biosynthetic process (inferred); mannose metabolic process (inferred); protein N-linked glycosylation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); cerebellar hypoplasia (ortholog); cerebral palsy (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); neuronal cell body (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1633,346,969 - 33,371,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl633,347,270 - 33,371,025 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha634,737,736 - 34,761,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0633,545,561 - 33,569,964 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl633,539,387 - 33,569,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1633,348,099 - 33,372,292 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0633,217,995 - 33,242,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0633,639,757 - 33,663,961 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PMM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1633,346,969 - 33,371,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl633,347,270 - 33,371,025 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha634,737,736 - 34,761,919 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0633,545,561 - 33,569,964 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl633,539,387 - 33,569,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1633,348,099 - 33,372,292 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0633,217,995 - 33,242,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0633,639,757 - 33,663,961 (-)NCBIUU_Cfam_GSD_1.0
PMM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,797,839 - 8,849,325 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,788,823 - 8,862,534 (+)EnsemblGRCh38hg38GRCh38
GRCh37168,891,696 - 8,943,182 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,799,193 - 8,850,684 (+)NCBINCBI36Build 36hg18NCBI36
Build 34168,799,192 - 8,850,684NCBI
Celera169,061,062 - 9,109,970 (+)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef168,814,114 - 8,864,329 (+)NCBIHuRef
CHM1_1168,891,570 - 8,943,150 (+)NCBICHM1_1
T2T-CHM13v2.0168,830,591 - 8,882,071 (+)NCBIT2T-CHM13v2.0
Pmm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,455,467 - 8,475,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,455,538 - 8,480,331 (+)EnsemblGRCm39 Ensembl
GRCm38168,637,613 - 8,657,608 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,637,674 - 8,662,467 (+)EnsemblGRCm38mm10GRCm38
MGSCv37168,637,800 - 8,657,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36168,553,028 - 8,572,845 (+)NCBIMGSCv36mm8
Celera169,282,962 - 9,302,773 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map164.24NCBI
Pmm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,468,371 - 7,489,574 (-)NCBIGRCr8
mRatBN7.2106,961,521 - 6,982,913 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl106,961,709 - 6,983,098 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1011,667,872 - 11,689,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,164,303 - 11,185,470 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0106,815,584 - 6,836,762 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0107,056,258 - 7,077,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl107,056,266 - 7,077,443 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0105,857,616 - 5,878,777 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4107,001,340 - 7,022,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1107,001,219 - 7,022,517 (-)NCBI
Celera105,957,089 - 5,978,249 (-)NCBICelera
Cytogenetic Map10q12NCBI
Pmm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554429,389,443 - 9,411,719 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554429,390,789 - 9,411,722 (-)NCBIChiLan1.0ChiLan1.0
PMM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,337,057 - 9,388,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11613,121,847 - 13,166,118 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,731,266 - 7,782,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,971,692 - 9,020,406 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,971,692 - 9,020,406 (+)Ensemblpanpan1.1panPan2
Pmm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344109,785,252 - 109,803,217 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365307,630,637 - 7,648,676 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365307,630,668 - 7,648,658 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl333,857,068 - 33,892,701 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1333,857,059 - 33,892,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2334,789,963 - 34,802,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PMM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.158,389,483 - 8,425,605 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl58,389,754 - 8,423,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606821,795,734 - 21,831,153 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248246,214,193 - 6,244,590 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PMM2
248 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 17 3 3 3 6 7 10 6
Low 5 5 3 3 3 6 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000030200   ⟹   ENSCAFP00000028063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl633,347,270 - 33,371,025 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000085573   ⟹   ENSCAFP00000055904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl633,347,270 - 33,371,025 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025025   ⟹   ENSCAFP00845019685
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl633,539,387 - 33,569,878 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025043   ⟹   ENSCAFP00845019703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl633,545,561 - 33,569,889 (-)Ensembl
RefSeq Acc Id: XM_022420080   ⟹   XP_022275788
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1633,346,969 - 33,371,095 (-)NCBI
Dog10K_Boxer_Tasha634,737,736 - 34,761,919 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038479200   ⟹   XP_038335128
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1633,348,099 - 33,372,292 (-)NCBI
RefSeq Acc Id: XM_038479201   ⟹   XP_038335129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1633,354,877 - 33,372,292 (-)NCBI
RefSeq Acc Id: XM_038540427   ⟹   XP_038396355
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0633,639,757 - 33,663,961 (-)NCBI
RefSeq Acc Id: XM_038540428   ⟹   XP_038396356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0633,646,539 - 33,663,961 (-)NCBI
RefSeq Acc Id: XM_038547625   ⟹   XP_038403553
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha634,744,513 - 34,761,919 (-)NCBI
RefSeq Acc Id: XM_038604526   ⟹   XP_038460454
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0633,217,995 - 33,242,140 (-)NCBI
RefSeq Acc Id: XM_038604527   ⟹   XP_038460455
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0633,224,764 - 33,242,140 (-)NCBI
RefSeq Acc Id: XM_038669212   ⟹   XP_038525140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0633,545,561 - 33,569,964 (-)NCBI
RefSeq Acc Id: XM_038669213   ⟹   XP_038525141
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0633,552,342 - 33,569,964 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022275788   ⟸   XM_022420080
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LM80 (UniProtKB/TrEMBL),   A0A8C0RFS9 (UniProtKB/TrEMBL),   A0A8I3NRW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000028063   ⟸   ENSCAFT00000030200
RefSeq Acc Id: ENSCAFP00000055904   ⟸   ENSCAFT00000085573
RefSeq Acc Id: XP_038335128   ⟸   XM_038479200
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038335129   ⟸   XM_038479201
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038460454   ⟸   XM_038604526
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460455   ⟸   XM_038604527
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038525140   ⟸   XM_038669212
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LM80 (UniProtKB/TrEMBL),   A0A8C0RFS9 (UniProtKB/TrEMBL),   A0A8I3NRW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038525141   ⟸   XM_038669213
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038403553   ⟸   XM_038547625
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038396355   ⟸   XM_038540427
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LM80 (UniProtKB/TrEMBL),   A0A8C0RFS9 (UniProtKB/TrEMBL),   A0A8I3NRW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396356   ⟸   XM_038540428
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845019703   ⟸   ENSCAFT00845025043
RefSeq Acc Id: ENSCAFP00845019685   ⟸   ENSCAFT00845025025

Promoters
RGD ID:13683702
Promoter ID:EPDNEW_C1769
Type:multiple initiation site
Name:PMM2_1
Description:phosphomannomutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1633,371,037 - 33,371,097EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019010 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008664 UniProtKB/TrEMBL
  ENSCAFG00040005482 UniProtKB/TrEMBL
  ENSCAFG00845013923 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030200.4 UniProtKB/TrEMBL
  ENSCAFT00000085573.2 UniProtKB/TrEMBL
  ENSCAFT00030015943.1 UniProtKB/TrEMBL
  ENSCAFT00030016006.1 UniProtKB/TrEMBL
  ENSCAFT00030016042.1 UniProtKB/TrEMBL
  ENSCAFT00040010299.1 UniProtKB/TrEMBL
  ENSCAFT00040010323.1 UniProtKB/TrEMBL
  ENSCAFT00845025025.1 UniProtKB/TrEMBL
  ENSCAFT00845025043 ENTREZGENE
  ENSCAFT00845025043.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1240.20 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
InterPro HAD-like_sf UniProtKB/TrEMBL
  HAD-SF_hydro_IIB UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  PMM UniProtKB/TrEMBL
  PMM_cap UniProtKB/TrEMBL
NCBI Gene PMM2 ENTREZGENE
PANTHER PHOSPHOMANNOMUTASE 2 UniProtKB/TrEMBL
  PTHR10466 UniProtKB/TrEMBL
Pfam PMM UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/TrEMBL
UniProt A0A8C0LM80 ENTREZGENE
  A0A8C0MME0_CANLF UniProtKB/TrEMBL
  A0A8C0MW77_CANLF UniProtKB/TrEMBL
  A0A8C0RFS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NRW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P1F2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44734 ENTREZGENE