ACAN (aggrecan) - Rat Genome Database

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Gene: ACAN (aggrecan) Canis lupus familiaris
Analyze
Symbol: ACAN
Name: aggrecan
RGD ID: 12122691
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cartilage condensation (ortholog); cellular response to growth factor stimulus (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Brain Injuries (ortholog); colon cancer (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AGC1; aggrecan 1; aggrecan core protein; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan 1; CSPCP; large aggregating proteoglycan, antigen
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,995,100 - 52,031,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,969,779 - 52,031,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,631,503 - 54,667,931 (+)NCBI
ROS_Cfam_1.0352,389,075 - 52,451,203 (+)NCBI
UMICH_Zoey_3.1351,936,640 - 51,973,031 (+)NCBI
UNSW_CanFamBas_1.0352,147,017 - 52,183,413 (+)NCBI
UU_Cfam_GSD_1.0352,485,855 - 52,522,279 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:7827755   PMID:8349621   PMID:8921002   PMID:23978557  


Genomics

Comparative Map Data
ACAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,995,100 - 52,031,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,969,779 - 52,031,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,631,503 - 54,667,931 (+)NCBI
ROS_Cfam_1.0352,389,075 - 52,451,203 (+)NCBI
UMICH_Zoey_3.1351,936,640 - 51,973,031 (+)NCBI
UNSW_CanFamBas_1.0352,147,017 - 52,183,413 (+)NCBI
UU_Cfam_GSD_1.0352,485,855 - 52,522,279 (+)NCBI
ACAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1588,803,436 - 88,875,353 (+)EnsemblGRCh38hg38GRCh38
GRCh381588,803,436 - 88,875,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371589,346,667 - 89,418,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,147,678 - 87,219,589 (+)NCBINCBI36hg18NCBI36
Build 341587,147,993 - 87,218,832NCBI
Celera1565,748,790 - 65,819,902 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1565,458,891 - 65,530,587 (+)NCBIHuRef
CHM1_11589,188,178 - 89,259,230 (+)NCBICHM1_1
Acan
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,702,974 - 78,764,847 (+)NCBIGRCm39mm39
GRCm39 Ensembl778,703,231 - 78,764,847 (+)Ensembl
GRCm38779,053,226 - 79,115,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,053,483 - 79,115,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv37786,198,369 - 86,259,985 (+)NCBIGRCm37mm9NCBIm37
MGSCv36778,926,996 - 78,988,612 (+)NCBImm8
Celera776,452,812 - 76,514,796 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.88NCBI
Acan
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21132,981,034 - 133,044,416 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1132,981,582 - 133,043,627 (+)Ensembl
Rnor_6.01140,762,758 - 140,824,441 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,762,758 - 140,824,441 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,732,130 - 141,793,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,787,341 - 134,848,992 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,865,683 - 134,927,335 (+)NCBI
Celera1125,052,984 - 125,114,449 (+)NCBICelera
Cytogenetic Map1q31NCBI
Acan
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541616,125,536 - 16,186,046 (-)NCBIChiLan1.0ChiLan1.0
ACAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11586,733,853 - 86,771,420 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,733,853 - 86,771,420 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01567,492,494 - 67,563,265 (+)NCBIMhudiblu_PPA_v0panPan3
Acan
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,487,810 - 131,554,134 (-)NCBI
SpeTri2.0NW_00493648314,811,152 - 14,846,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,449,588 - 54,520,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,449,830 - 54,520,606 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,444,443 - 59,484,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,345,350 - 7,416,951 (+)NCBI
Vero_WHO_p1.0NW_02366605939,423,196 - 39,494,914 (-)NCBI
Acan
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476816,093,552 - 16,156,655 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 6 3 2
Below cutoff 5 5 16 3 6 3 6 6 6 8 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002034   ⟹   ENSCAFP00000001882
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl351,969,779 - 52,031,544 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000018302   ⟹   ENSCAFP00000016949
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl351,997,455 - 52,031,544 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000082004   ⟹   ENSCAFP00000065577
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl351,969,779 - 52,031,544 (+)Ensembl
RefSeq Acc Id: NM_001113455   ⟹   NP_001106926
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1351,995,115 - 52,031,544 (+)NCBI
Dog10K_Boxer_Tasha354,631,503 - 54,667,931 (+)NCBI
ROS_Cfam_1.0352,414,095 - 52,450,486 (+)NCBI
UMICH_Zoey_3.1351,936,640 - 51,973,031 (+)NCBI
UNSW_CanFamBas_1.0352,147,017 - 52,183,413 (+)NCBI
UU_Cfam_GSD_1.0352,485,855 - 52,522,279 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005618252   ⟹   XP_005618309
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1351,995,100 - 52,031,812 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038660458   ⟹   XP_038516386
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0352,389,075 - 52,451,203 (+)NCBI
RefSeq Acc Id: XM_038660459   ⟹   XP_038516387
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0352,389,077 - 52,451,203 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001106926 (Get FASTA)   NCBI Sequence Viewer  
  XP_038516386 (Get FASTA)   NCBI Sequence Viewer  
  XP_038516387 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB06238 (Get FASTA)   NCBI Sequence Viewer  
  AAC60527 (Get FASTA)   NCBI Sequence Viewer  
  Q28343 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005618309   ⟸   XM_005618252
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001106926   ⟸   NM_001113455
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSCAFP00000065577   ⟸   ENSCAFT00000082004
RefSeq Acc Id: ENSCAFP00000016949   ⟸   ENSCAFT00000018302
RefSeq Acc Id: ENSCAFP00000001882   ⟸   ENSCAFT00000002034
RefSeq Acc Id: XP_038516386   ⟸   XM_038660458
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038516387   ⟸   XM_038660459
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011534 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000065577 ENTREZGENE
Ensembl Transcript ENSCAFT00000082004 ENTREZGENE
NCBI Gene ACAN ENTREZGENE
UniProt Q28343 ENTREZGENE
VGNC ID VGNC:37495 ENTREZGENE