MFAP4 (microfibril associated protein 4) - Rat Genome Database

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Gene: MFAP4 (microfibril associated protein 4) Canis lupus familiaris
Analyze
Symbol: MFAP4
Name: microfibril associated protein 4
RGD ID: 12121228
Description: INVOLVED IN cellular response to UV-B (inferred); elastic fiber assembly (inferred); regulation of collagen metabolic process (inferred); ASSOCIATED WITH autistic disorder (ortholog); common variable immunodeficiency 2 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN collagen-containing extracellular matrix (inferred); elastic fiber (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: microfibril-associated glycoprotein 4; microfibrillar associated protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,828,548 - 40,831,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,828,282 - 40,831,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,969,718 - 40,972,901 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0540,936,178 - 40,939,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,936,212 - 40,939,363 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,904,512 - 40,907,695 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,851,289 - 40,854,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,043,387 - 41,046,570 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MFAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,828,548 - 40,831,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,828,282 - 40,831,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,969,718 - 40,972,901 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0540,936,178 - 40,939,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,936,212 - 40,939,363 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,904,512 - 40,907,695 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,851,289 - 40,854,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,043,387 - 41,046,570 (+)NCBIUU_Cfam_GSD_1.0
MFAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,383,445 - 19,387,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1719,383,442 - 19,387,190 (-)EnsemblGRCh38hg38GRCh38
GRCh371719,286,758 - 19,290,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,227,348 - 19,231,086 (-)NCBINCBI36Build 36hg18NCBI36
Build 341719,227,348 - 19,231,086NCBI
Celera1716,699,566 - 16,703,304 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1718,666,324 - 18,670,101 (-)NCBIHuRef
CHM1_11719,295,503 - 19,299,280 (-)NCBICHM1_1
T2T-CHM13v2.01719,331,480 - 19,335,225 (-)NCBIT2T-CHM13v2.0
Mfap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,376,257 - 61,379,536 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,376,257 - 61,379,726 (+)EnsemblGRCm39 Ensembl
GRCm381161,485,431 - 61,488,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,485,431 - 61,488,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv371161,298,946 - 61,302,206 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,301,639 - 61,304,899 (+)NCBIMGSCv36mm8
MGSCv361161,915,401 - 61,918,679 (+)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Mfap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,666,552 - 46,669,613 (+)NCBIGRCr8
mRatBN7.21046,167,158 - 46,170,176 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,167,217 - 46,170,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,870,472 - 50,873,434 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,360,995 - 50,363,957 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,864,422 - 45,867,384 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,765,463 - 47,768,484 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,765,432 - 47,768,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,537,965 - 47,540,978 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,646,157 - 47,649,095 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,659,771 - 47,662,910 (+)NCBI
Celera1045,418,983 - 45,421,921 (+)NCBICelera
Cytogenetic Map10q22NCBI
Mfap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467377,887 - 381,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955467378,389 - 381,593 (+)NCBIChiLan1.0ChiLan1.0
MFAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,392,825 - 54,397,057 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11759,205,453 - 59,209,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,725,732 - 31,729,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,890,461 - 36,894,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,890,778 - 36,893,230 (+)Ensemblpanpan1.1panPan2
Mfap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560260,214,635 - 60,218,270 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936881368,877 - 373,974 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936881369,161 - 372,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,137,566 - 60,144,207 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,141,488 - 60,144,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,968,925 - 17,972,676 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,969,945 - 17,972,978 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660592,878,547 - 2,882,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,661,920 - 5,664,970 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,661,916 - 5,665,290 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MFAP4
35 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 5 5 6 6 1 8 6
Low 5 17 6 6 5 6 1
Below cutoff 6 8

Sequence


RefSeq Acc Id: ENSCAFT00000048232   ⟹   ENSCAFP00000038288
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl540,828,282 - 40,831,495 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000072204   ⟹   ENSCAFP00000047279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl540,828,282 - 40,830,847 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078987   ⟹   ENSCAFP00000049819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl540,828,619 - 40,830,847 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032870   ⟹   ENSCAFP00845025723
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl540,936,212 - 40,939,363 (+)Ensembl
RefSeq Acc Id: XM_038475870   ⟹   XP_038331798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1540,904,512 - 40,907,695 (+)NCBI
RefSeq Acc Id: XM_038537058   ⟹   XP_038392986
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0541,043,387 - 41,046,570 (+)NCBI
RefSeq Acc Id: XM_038601195   ⟹   XP_038457123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0540,851,289 - 40,854,472 (+)NCBI
RefSeq Acc Id: XM_038665760   ⟹   XP_038521688
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0540,936,178 - 40,939,363 (+)NCBI
RefSeq Acc Id: XM_546650   ⟹   XP_546650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1540,828,548 - 40,831,757 (+)NCBI
Dog10K_Boxer_Tasha540,969,718 - 40,972,901 (+)NCBI
Sequence:
RefSeq Acc Id: XP_546650   ⟸   XM_546650
- UniProtKB: A0A8C0L954 (UniProtKB/TrEMBL),   A0A8C0MHU2 (UniProtKB/TrEMBL),   A0A8I3P2W7 (UniProtKB/TrEMBL),   A0A8C0Q456 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049819   ⟸   ENSCAFT00000078987
RefSeq Acc Id: ENSCAFP00000038288   ⟸   ENSCAFT00000048232
RefSeq Acc Id: ENSCAFP00000047279   ⟸   ENSCAFT00000072204
RefSeq Acc Id: XP_038331798   ⟸   XM_038475870
RefSeq Acc Id: XP_038457123   ⟸   XM_038601195
RefSeq Acc Id: XP_038521688   ⟸   XM_038665760
- UniProtKB: A0A8C0L954 (UniProtKB/TrEMBL),   A0A8C0MHU2 (UniProtKB/TrEMBL),   A0A8I3P2W7 (UniProtKB/TrEMBL),   A0A8C0Q456 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392986   ⟸   XM_038537058
- UniProtKB: A0A8C0L954 (UniProtKB/TrEMBL),   A0A8C0MHU2 (UniProtKB/TrEMBL),   A0A8C0Q456 (UniProtKB/TrEMBL),   A0A8I3P2W7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845025723   ⟸   ENSCAFT00845032870
Protein Domains
Fibrinogen C-terminal

Promoters
RGD ID:13683274
Promoter ID:EPDNEW_C1342
Type:multiple initiation site
Name:MFAP4_1
Description:microfibril associated protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1540,828,621 - 40,828,681EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030269 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006496 UniProtKB/TrEMBL
  ENSCAFG00040001960 UniProtKB/TrEMBL
  ENSCAFG00845018581 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000048232.3 UniProtKB/TrEMBL
  ENSCAFT00000078987.2 UniProtKB/TrEMBL
  ENSCAFT00030011966.1 UniProtKB/TrEMBL
  ENSCAFT00030012009.1 UniProtKB/TrEMBL
  ENSCAFT00040003697.1 UniProtKB/TrEMBL
  ENSCAFT00040003790.1 UniProtKB/TrEMBL
  ENSCAFT00845032870 ENTREZGENE
  ENSCAFT00845032870.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/TrEMBL
KEGG Report cfa:489531 UniProtKB/TrEMBL
NCBI Gene MFAP4 ENTREZGENE
PANTHER FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/TrEMBL
  MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 4 UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PROSITE FIBRINOGEN_C_2 UniProtKB/TrEMBL
SMART FBG UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/TrEMBL
UniProt A0A8C0L954 ENTREZGENE
  A0A8C0MHU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q0L8_CANLF UniProtKB/TrEMBL
  A0A8C0Q456 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P2W7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0T2K5 UniProtKB/TrEMBL
VGNC ID VGNC:43190 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 MFAP4  microfibril associated protein 4    microfibrillar associated protein 4  Symbol and/or name change 5135510 APPROVED